A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin

Otting, Nel; Heijmans, Corrine M. C.; Wiel, Marit K. van der; Groot, Natasja G. de; Doxiadis, Gaby G. M.; Bontrop, Ronald E.

doi:10.1007/s00251-008-0311-5

Cited by 51 publications

(67 citation statements)

References 48 publications

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“…Both Mamu-A and Mamu-B regions are characterized by complex gene configurations that significantly contribute to MHC class I genetic diversity (27,28). The Mamu-A region of Indian rhesus macaques is characterized by four Mamu-A genes (22), and we included in our analysis at least one representative of these.…”

Section: Molecular Interaction Of Mamu-a and Mamu-b Molecules With Kimentioning

confidence: 99%

“…Both KIR and MHC class I genes of human and macaques show ample differences. Whereas in great apes and human, expansions of lineage III KIRs (KIR2D) coincide with emergence of MHC-C (24), macaques expanded lineage II KIRs (KIR3D) (20,21,25,26) along with substantial expansion of MHC-A and MHC-B genes (27)(28)(29) and lack of a MHC-C type of class I genes (22,30). However, as known for HIV infection, also rhesus macaque MHC class I alleles and haplotypes are associated with susceptibility/resistance to infections with SIV, the most prominent allele being Mamu-A1*001:01, which is associated with longer survival and lower viral loads upon experimental SIV infection (31,32).…”

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confidence: 99%

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Rhesus Macaque Inhibitory and Activating KIR3D Interact with Mamu-A–Encoded Ligands

Rosner

Kruse

Hermes

et al. 2011

The Journal of Immunology

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Specific interactions between killer cell Ig-like receptors (KIRs) and MHC class I ligands have not been described in rhesus macaques despite their importance in biomedical research. Using KIR–Fc fusion proteins, we detected specific interactions for three inhibitory KIRs (3DLW03, 3DL05, 3DL11) and one activating KIR (3DS05). As ligands we identified Macaca mulatta MHC (Mamu)-A1– and Mamu-A3–encoded allotypes, among them Mamu-A1*001:01, which is well known for association with slow progression to AIDS in the rhesus macaque experimental SIV infection model. Interactions with Mamu-B or Mamu-I molecules were not found. KIR3DLW03 and KIR3DL05 differ in their binding sites to their shared ligand Mamu-A1*001:01, with 3DLW03 depending on presence of the α1 domain, whereas 3DL05 depends on both the α1 and α2 domains. Fine-mapping studies revealed that binding of KIR3DLW03 is influenced by presence of the complete Bw4 epitope (positions 77, 80–83), whereas that of KIR3DL05 is mainly influenced by amino acid position 77 of Bw4 and positions 80–83 of Bw6. Our findings allowed the successful prediction of a further ligand of KIR3DL05, Mamu-A1*002:01. These functional differences of rhesus macaque KIR3DL molecules are in line with the known genetic diversification of lineage II KIRs in macaques.

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Section: Molecular Interaction Of Mamu-a and Mamu-b Molecules With Kimentioning

confidence: 99%

mentioning

confidence: 99%

Rhesus Macaque Inhibitory and Activating KIR3D Interact with Mamu-A–Encoded Ligands

Rosner

Kruse

Hermes

et al. 2011

The Journal of Immunology

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“…Haplotypes were defined by segregation analyses and named according to the founder animals, in which the haplotype was originally observed. Over the last two decades, serotyping has been replaced by molecular techniques like full-length cDNA sequencing for class I (Boyson et al 1996; Otting et al 2007; Otting et al 2005; Otting et al 2008) and sequencing of the most polymorphic exon 2 of the various class II genes (Bontrop et al 1999; Doxiadis et al 2001; Doxiadis et al 2000; Khazand et al 1999; Otting et al 2002; Otting et al 2000; Otting et al 1998; Slierendregt et al 1995; Slierendregt et al 1994). In Indian rhesus macaques, DP and DQ molecules are encoded by a single pair of genes: namely, DPA1 / DPB1 and DQA1 / DQB1 , respectively.…”

Section: Introductionmentioning

confidence: 99%

Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques

et al. 2013

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The Mamu-A, Mamu-B, and Mamu-DRB genes of the rhesus macaque show several levels of complexity such as allelic heterogeneity (polymorphism), copy number variation, differential segregation of genes/alleles present on a haplotype (diversity) and transcription level differences. A combination of techniques was implemented to screen a large panel of pedigreed Indian rhesus macaques (1,384 individuals representing the offspring of 137 founding animals) for haplotype diversity in an efficient and inexpensive manner. This approach allowed the definition of 140 haplotypes that display a relatively low degree of region variation as reflected by the presence of only 17 A, 18 B and 22 DRB types, respectively, exhibiting a global linkage disequilibrium comparable to that in humans. This finding contrasts with the situation observed in rhesus macaques from other geographic origins and in cynomolgus monkeys from Indonesia. In these latter populations, nearly every haplotype appears to be characterised by a unique A, B and DRB region. In the Indian population, however, a reshuffling of existing segments generated “new” haplotypes. Since the recombination frequency within the core MHC of the Indian rhesus macaques is relatively low, the various haplotypes were most probably produced by recombination events that accumulated over a long evolutionary time span. This idea is in accord with the notion that Indian rhesus macaques experienced a severe reduction in population during the Pleistocene due to a bottleneck caused by geographic changes. Thus, recombination-like processes appear to be a way to expand a diminished genetic repertoire in an isolated and relatively small founder population.Electronic supplementary materialThe online version of this article (doi:10.1007/s00251-013-0707-8) contains supplementary material, which is available to authorized users.

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“…But the critical reagents for vaccine research, such as MHC class I tetramers, are currently only designed on the immunogenetic background of Indian rhesus macaques, while the two geographic macaque populations share few common MHC class I alleles (2,10,(17)(18)(19). This study was intended to set up a procedure for constructing new tetramers on the immunogenetic background of Chinese macaques.…”

Section: Discussionmentioning

confidence: 99%

Construction of Soluble Mamu-B*1703, a Class I Major Histocompatibility Complex of Chinese Rhesus Macaques, Monomer and Tetramer Loaded with a Simian Immunodeficiency Virus Peptide

Ouyang

Wang

et al. 2009

Cell Mol Immunol

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Chinese-descent rhesus macaques have become more prevalent for HIV infection and vaccine investigation than Indian-origin macaques. Most of the currently available data and reagents such as major histocompatibility complex (MHC) class I tetramers, however, were derived from Indian-origin macaques due to the dominant use of these animals in history. Although there are significant differences in the immunogenetic background between the two macaque populations, they share a few of common MHC class I alleles. We reported in this study the procedure for preparation of a soluble Mamu-B*1703 (a MHC class I molecule of Chinese macaques) monomer and tetramer loaded with a dominant simian immunodeficiency virus (SIV) epitope IW9 (IRYPKTFGW) that was identified to be Mamu-B*1701-restricted in Indian macaques. The DNA fragment encoding the Mamu-B*1703 extracellular domain fused with a BirA substrate peptide (BSP) was amplified from a previously cloned cDNA and inserted into a prokaratic expression vector. In the presence of the antigenic peptide IW9 and light chain  2 -microglobulin, the expressed heavy chain was refolded into a soluble monomer. After biotinylation, four monomers were polymerized as a tetramer by phycoerythrin-conjugated streptavidin. The tetramer, having been confirmed to have the right conformation, was a potential tool for investigation of antigen-specific CD8 + T-lymphocytes in SIV vaccine models of Chinese macaques. And our results also suggested that some antigenic peptides reported in Indian-origin macaques could be directly recruited as ligands for construction of Chinese macaque MHC tetramers. Cellular & Molecular Immunology. 2009;6(2):117-122.

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A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin

Cited by 51 publications

References 48 publications

Rhesus Macaque Inhibitory and Activating KIR3D Interact with Mamu-A–Encoded Ligands

Rhesus Macaque Inhibitory and Activating KIR3D Interact with Mamu-A–Encoded Ligands

Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques

Construction of Soluble Mamu-B*1703, a Class I Major Histocompatibility Complex of Chinese Rhesus Macaques, Monomer and Tetramer Loaded with a Simian Immunodeficiency Virus Peptide

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