A SNAI2/CTCF Interaction is Required for
NOTCH1
Expression in Rhabdomyosarcoma
Prethish Sreenivas,
Long Wang,
Meng Wang
et al.
Abstract:Rhabdomyosarcoma (RMS) is a pediatric malignancy of the muscle with characteristics of cells blocked in differentiation.
NOTCH1
is an oncogene that promotes self-renewal and blocks differentiation in the fusion negative-RMS sub-type. However, how
NOTCH1
expression is transcriptionally maintained in tumors is unknown. Analyses of SNAI2 and CTCF chromatin binding and HiC analyses revealed a conserved SNAI2/CTCF overlapping peak downstream of the
NOTCH1
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