A smartphone-based dual detection mode device integrated with two lateral flow immunoassays for multiplex mycotoxins in cereals

Liu, Zhiwei; Hua, Qicheng; Jin, Wang; Liang, Zaoqing; Li, Jiahao; Wu, Jiasheng; Shen, Xing; Lei, Hongtao; Li, Xiangmei

doi:10.1016/j.bios.2020.112178

Cited by 146 publications

(67 citation statements)

References 29 publications

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“…The assays provide mainly visual qualitative results, however, semi-quantitative results for any positive samples can be also achieved with dedicated handheld devices. LFDs for multi mycotoxin detection in food and feed are also available [142][143][144]. A description of different LFDs for mycotoxin detection is presented in Table 2, showing various commercial entities offering LFDs validated for OTA and aflatoxin detection in wine and grape products, among other matrices.…”

Section: Lateral Flow and Flow-through Immunoassays (Lfia Ftia)mentioning

confidence: 99%

Recent Advances in Mycotoxin Analysis and Detection of Mycotoxigenic Fungi in Grapes and Derived Products

Kizis

Vichou

Natskoulis³

2021

Sustainability

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Mycotoxins are secondary metabolites of filamentous fungi that can cause toxic effects in human and animal health. Most of the filamentous fungi that produce these mycotoxins belong to four genera, namely, Aspergillus, Penicillium, Fusarium, and Alternaria. Mycotoxigenic fungi, along with mycotoxins, create a constant and serious economic threat for agriculture in many terms, counting product losses due to crop contamination and food spoilage, as well malnutrition when considering nutritional quality degradation. Given the importance of robust and precise diagnostics of mycotoxins and the related producing fungi in the grape food chain, one of the most important agricultural sectors worldwide, the present review initially delivers a comprehensive presentation of mycotoxin reports on grape and derived products, including a wide range of commodities such as fresh grapes, raisins, wine, juices, and other processed products. Next, based on worldwide regulations’ requirements for mycotoxins, and referring to the relative literature, this work presents methodological approaches for mycotoxin determination, and stresses major methods for the detection of fungal species responsible for mycotoxin production. The principle of function and basic technical background on the available analytical and molecular biology techniques developed—including chromatography, mass spectrometry, immunochemical-based assays, biosensors, and molecular assays—is briefly given, and references for their application to grape and derived product testing are highlighted.

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Section: Lateral Flow and Flow-through Immunoassays (Lfia Ftia)mentioning

confidence: 99%

Recent Advances in Mycotoxin Analysis and Detection of Mycotoxigenic Fungi in Grapes and Derived Products

Kizis

Vichou

Natskoulis³

2021

Sustainability

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“…Another strategy of colorimetric signal generating relies on nanomaterial-based labels like common in lateral flow immunochromatographic assays (LFIAs). A number of NMs was described as antibodies' nano-labels for the visual rapid detection of mycotoxins [29], such as AuNPs [30], graphene oxide (GO) [31], Prussian blue nanoparticles (PBNPs) [32], etc. In such devices, the color of test lines is usually drawn by the labeled antibodies in-volved in specific immunoreactions (cf.…”

Section: Nanomaterial-based Probesmentioning

confidence: 99%

“…Toxins 2021, 13, x FOR PEER REVIEW 9 o [29], such as AuNPs [30], graphene oxide (GO) [31], Prussian blue nanoparticles (PBN [32], etc. In such devices, the color of test lines is usually drawn by the labeled antibod involved in specific immunoreactions (cf.…”

Section: Nanomaterial-based Probesmentioning

confidence: 99%

“…Therefore, these existing limitations must be overcome to receive a practical LFA for multiplex and on-site detection. For this purpose, Liu et al developed two kinds of multiplexed LFA strips using AuNPs and time-resolved fluorescence microspheres (TRFMs) as label for the detection of AFB1, zearalenone (ZEN), deoxynivalenol (DON), T-2 toxin (T-2), and fumonisin B1 (FMB1) in cereals (Figure 5b) [30]. Five test lines were sprayed on a single test strip for each mode of detection.…”

Section: Lateral Flow Assaysmentioning

confidence: 99%

“…Many efforts have been made for the development of quantitative and multiplex LFIA test strips. In this regard, LFIA based on AuNPs and TRFMs for multiplex detection of AFB1, ZEN, FMB1, DON, and T-2 toxin along with a smartphone-based quantitative dual detection mode device [30] is a good example of a multiplex and quantitative analysis (Table 3). Developed strips showed high sensitivity and reliability.…”

Section: Interesting Examples From Literature With Great Potential For Industrial Applicationsmentioning

confidence: 99%

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Advances in Colorimetric Strategies for Mycotoxins Detection: Toward Rapid Industrial Monitoring

Majdinasab

Aissa

Marty

2020

Toxins

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Mycotoxins contamination is a global public health concern. Therefore, highly sensitive and selective techniques are needed for their on-site monitoring. Several approaches are conceivable for mycotoxins analysis, among which colorimetric methods are the most attractive for commercialization purposes thanks to their visual read-out, easy operation, cost-effectiveness, and rapid response. This review covers the latest achievements in the last five years for the development of colorimetric methods specific to mycotoxins analysis, with a particular emphasis on their potential for large-scale applications in food industries. Gathering all types of (bio)receptors, main colorimetric methods are critically discussed, including enzyme-linked assays, lateral flow-assays, microfluidic devices, and homogenous in-solution strategies. This special focus on colorimetry as a versatile transduction method for mycotoxins analysis is comprehensively reviewed for the first time.

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Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

Zhang

et al. 2020

Food Frontiers

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Mycotoxins, a toxic secondary metabolite, unpredictably, and unavoidably occur in foods and feeds, leading to adverse health impacts and enormous economic losses in the agriculture industry. Moreover, mycotoxin contamination has been a great threat for the public health and agriculture economy development worldwide. Therefore, the control of the mycotoxin contamination is of great importance and has caused rising concern worldwide. Recently, emerging nanomaterials have been promisingly applied in the control of mycotoxin contamination and have obtained many achievements. In this review, first of all, the type, occurrence, and toxicity of mycotoxins are simply discussed. Then, attentions are focused on the applications of emerging nanomaterials to controlling the mycotoxin contamination, including mycotoxin assay, the inhibition of mycotoxin production, the adsorption of mycotoxins, and mycotoxin elimination. In the end, the future opportunities and challenges on the toxicity, occurrence, and control of mycotoxins are tentatively put forward.

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A smartphone-based dual detection mode device integrated with two lateral flow immunoassays for multiplex mycotoxins in cereals

Cited by 146 publications

References 29 publications

Recent Advances in Mycotoxin Analysis and Detection of Mycotoxigenic Fungi in Grapes and Derived Products

Recent Advances in Mycotoxin Analysis and Detection of Mycotoxigenic Fungi in Grapes and Derived Products

Advances in Colorimetric Strategies for Mycotoxins Detection: Toward Rapid Industrial Monitoring

Recent advances on emerging nanomaterials for controlling the mycotoxin contamination: From detection to elimination

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