A Smart Nanovector of Cationic Starch Modified Curcumin with Excellent Targeting and Sonodynamic Properties for Effective Therapy of MRSA‐Induced Osteomyelitis

Abstract

Drugs treatment including antibiotics or herbal medicines cannot cure osteomyelitis effectively accompanied by drug‐resistance bacteria and even amputation after long‐term debridement. Herein, a materioherbological strategy is utilized to construct a smart nanovector of cationic starch (CS) modified curcumin nanoparticles (CS@Cur NPs) for treating methicillin‐resistant Staphylococcus aureus (MRSA) induced osteomyelitis. On the one hand, CS modification can reduce the π–π accumulation of curcumin to endow the nanocomposite with excellent water solubility. On the other hand, the hydroxyl group in the curcumin is hydrogen‐bonded to the carbonyl group in the monomer (methyl methacrylate, MMA) of CS, resulting in a decrease in both the bandgap (between the highest and lowest occupied molecular orbitals, labeled as ΔE) and the S1–T1 energy gap (ΔES‐T) while the spin–orbital coupling (SOC) values increase, which benefits the formation of triplet‐state molecules under ultrasonic irradiation, significantly improving the yields of reactive oxygen species (ROS) capacity. The CS@Cur NPs nanocomposite constructed in this paper produced a large number of ROS synergic targeting effects under continuous 15 min ultrasonic irradiation, the clearance rate of MRSA infection induced osteomyelitis in rats can be as high as 99.93%. This study provides a new therapeutic strategy for the treatment of osteomyelitis induced by pathogenic bacteria.

Garlic-Derived Exosome-like Nanovesicles-Based Wound Dressing for Staphylococcus aureus Infection Visualization and Treatment

“…Preparation of Gel Van@GELNs. For Pluronic F127 hydrogel preparation, Pluronic F127 solutions at different concentrations (10,15,20,25, and 30 wt %) were prepared by dissolving Pluronic F127 in deionized water at 4 °C for 1 day with magnetic stirring. To realize sol−gel transition, the Pluronic F127 solution was incubated at different times (0, 15, 30, 45, and 60 s) and temperatures (4, 15, 20, 25, and 37 °C).…”

“…As a facultative anaerobe, Staphylococcus aureus (S. aureus) is capable of creating an intracellular infection reservoir in several types of host cells, such as dendritic cells, macrophages, and aggressive cancer cells, leading to recurrent infectious diseases. − It can also establish secondary infection foci in the host cells. When the host cells were taken up by macrophages, S.…”

MoO3 Nanorods Coated with MoS2 Nanosheets for Photocatalytic Elimination of Bacteria and Formaldehyde

“…Currently, the commonly used methods of formaldehyde degradation are physical adsorption, chemical absorption method, thermal destruction method, low-temperature catalytic method, biofilm method, and photocatalytic oxidation method. − However, physical adsorption has limited removal capacity and loses its effect once adsorption reaches its upper limit; chemical absorption is costly, and some of the reagents used are toxic and difficult to recycle; thermal degradation requires high temperatures and is not suitable for indoor use; low-temperature plasma technology generates a large number of new pollutants. As for antimicrobial, compared to traditional endogenous antimicrobial methods, exogenous antimicrobial strategies, including microwave-assisted, ultrasonic excited, and light-triggered, − can rapidly kill bacteria in a short period of time and do not induce bacterial resistance, have attracted more and more attention. Therefore, the idea of constructing multifunctional coatings using photocatalytic technology was proposed by combining the above methods of eliminating formaldehyde and antibacterials.…”