A smart copper(<scp>ii</scp>)-responsive binuclear gadolinium(<scp>iii</scp>) complex-based magnetic resonance imaging contrast agent

Xiao, Yi; Zhao, Guiyan; Fang, Xinxiu; Zhao, Yukun; Wang, Guan-hua; Yang, Wei; Xu, Jingwei

doi:10.1039/c4ra04526b

Cited by 16 publications

(12 citation statements)

References 70 publications

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“…R1obs values measured over the time ( Figure S13) show that the complexes are kinetically inert, even in the presence of 3-fold excess Cu 2+ . 70 Additional LC-MS data showed that in the Figure 5. XANES spectra for GdL1 in the presence of Cu 2+ and HSA.…”

Section: Water Exchange Ratesmentioning

confidence: 99%

A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo

et al. 2019

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The design, synthesis, and properties of a new gadolinium-based copper-responsive MRI contrast agents are presented in detail here. The sensor (GdL1) has high selectivity for copper ions and exhibits a 47% increase in r1 relaxivity upon binding to 1 equivalent of Cu 2+ in aqueous buffer. Interestingly, in the presence of physiological levels of human serum albumin (HSA), the r1 relaxivity is amplified even further up to 270%. Additional spectroscopic and XAS studies show that Cu 2+ is coordinated by two carboxylic acid groups and the single amine group on an appended side-chain of GdL1 and forms a ternary complex with HSA (GdL1-Cu 2+-HSA). T1-weighted in vivo imaging demonstrates that GdL1 can detect basal, endogenous labile copper(II) ions in living mice. This offers a unique opportunity to explore the role of copper ions in the development and progression of neurological diseases such as Wilson disease.

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Section: Water Exchange Ratesmentioning

confidence: 99%

A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo

et al. 2019

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“…In this study, we designed and synthesized a binuclear Tb 3+ complex according to the previous method [38], in which two DO3A rings (1,4,7,10-tetraazacyclododecane 1,4,7-triacetic acid) [39] for Tb 3+ chelating were connected with a 2,6-bis(pyrazol-1-yl) pyridine scaffold that functioned as a receptor for Cu 2+ coordination. The luminescence probe L was synthesized by the nucleophilic substitution reaction of compound 1 with compound 2 by three steps (Scheme 1), the detailed synthesis steps were described in the support information (Scheme S1).…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

A terbium-based time-resolved luminescent probe for sulfide ions mediated by copper in aqueous solution

Xiao

Yang

Zhao

et al. 2014

Inorganic Chemistry Communications

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“…R1obs values measured over the time (Figure S13) show that the complexes are kinetically inert, even in the presence of 3-fold excess Cu 2+ . 70 Additional LC-MS data showed that in the…”

Section: Kinetic Inertnessmentioning

confidence: 99%

A Responsive MRI Contrast Agent for Detection of Excess copper(II) in the Liver in Vivo

Paranawithana¹,

Clavijo-Jordan²,

Zhao³

et al. 2018

Preprint

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<div> The design, synthesis, and properties of a new gadolinium-based copper-responsive MRI contrast agents are presented in detail here. The sensor (GdL1) has high selectivity for copper ions and exhibits a 47% increase in r1 relaxivity upon binding to 1 equivalent of Cu2+ in aqueous buffer. Interestingly, in the presence of physiological levels of human serum albumin (HSA), the r1 relaxivity is amplified even further up to 270%. Additional spectroscopic and XAS studies show that Cu2+ is coordinated by two carboxylic acid groups and the single amine group on an appended side-chain of GdL1 and forms a ternary complex with HSA (GdL1-Cu2+-HSA). T1-weighted in vivo imaging demonstrates that GdL1 can detect basal, endogenous labile copper(II) ions in living mice. This offers a unique opportunity to explore the role of copper ions in the development and progression of neurological diseases such as Wilson disease. </div>

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A smart copper(ii)-responsive binuclear gadolinium(iii) complex-based magnetic resonance imaging contrast agent

Abstract: The relaxivity of the complex was modulated by Cu2+, that is, in the absence of Cu2+ the complex exhibited a relatively low relaxivity value of 6.40 mM−1 s−1, while the addition of Cu2+ triggered the relaxivity to 11.28 mM−1 s−1, an enhancement of approximately 76%.

Cited by 16 publications

References 70 publications

A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo

A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo

A terbium-based time-resolved luminescent probe for sulfide ions mediated by copper in aqueous solution

A Responsive MRI Contrast Agent for Detection of Excess copper(II) in the Liver in Vivo

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