A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrO<sub>2</sub>nanoparticles

Shi, Haitang; Niu, Meng; Tan, Longfei; Liu, Tianlong; Shao, Haibo; Fu, Changhui; Ren, Xiangling; Ma, Tengchuang; Ren, Jun; Li, Linlin; Liu, Huiyu; Xu, Ke; Wang, Jianxin; Tang, Fangqiong; Meng, Xianwei

doi:10.1039/c5sc00781j

Cited by 75 publications

(51 citation statements)

References 38 publications

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“…The Fano fibered-sensor probe may go beyond the limits that the actual probes present. In addition, the probe can also fulfill the needs of two recent cutting-edge technologies, known as Microwave Therapy and Irreversible Electroploration (IRE) technique, which are giving promising results for the treatment of cancer 61–63 . These techniques use highly localized E-fields for the ablation of tumoral cells which requires ultra-compact and high resolution probes to monitor the applied E-field distribution on the tissue in order to avoid side effects.…”

Section: Resultsmentioning

confidence: 99%

An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology

Calero

Suárez

Salut

et al. 2019

Sci Rep

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Non-intrusive, wide bandwidth and spatial resolution are terms often heard in electric field sensing. Despite of the fact that conventional electromagnetic field probes (EMF) can exhibit notable functional performances, they fail in terms of perturbation of the E-field due to their loaded metallic structure. In addition, even though electro-optical technology offers an alternative, it requires large interaction lenghts which severely limit the sensing performances in terms of bandwidth and spatial resolution. Here, we focus on miniaturizing the interaction volume, photon lifetime and device footprint by taking advantage of the combination of lithium niobate (LN), Lab-on-Fiber technologies and photonic crystals (PhC). We demonstrate the operation of an all-dielectric E-field sensor whose ultra-compact footprint is inscribed in a 125 μm-diameter circle with an interaction area smaller than 19 μm × 19 μm and light propagation length of 700 nm. This submicrometer length provides outstanding bandwidth flatness, in addition to be promising for frequency detection beyond the THz. Moreover, the minituarization also provides unique features such as spatial resolution under 10 μm and minimal perturbation to the E-field, accompanied by great linearity with respect to the E-field strength. All these specifications, summarized to the high versatibility of Lab-on-Fiber technology, lead to a revolutionary and novel fibered E-field sensor which can be adapted to a broad range of applications in the fields of telecommunications, health and military.

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Section: Resultsmentioning

confidence: 99%

An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology

Calero

Suárez

Salut

et al. 2019

Sci Rep

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“…To the best of our knowledge, Zr-doped NPs have been reported as a novel CT contrast agent, owing to the high X-ray attenuation effect (Shi et al., 2015 ; Tan et al., 2016 ). The CT imaging effect of Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform with different concentrations was also evaluated by X-ray CT.…”

Section: Resultsmentioning

confidence: 99%

Gadolinium-doped hollow CeO₂-ZrO₂ nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle

Wei

et al. 2018

Drug Delivery

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Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO2-ZrO2/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO2-ZrO2/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.

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“…With the development of nanomedicine, a series of nanosensitive materials have been used for MTT to improve the microwave heating efficiency, such as ball‐in‐ball ZrO 2 nanoparticles, layered MoS 2 nanoflowers, hollow polydopamine nanoparticles and ionic liquids in particular. Ionic liquid, as the most well‐known microwave heating material, has good microwave heating effect through the valid conversion from electromagnetic energy to thermal energy in limited space owing to its ionic properties and excellent polarizability . However, traditional loading materials usually have the risk of leaking them out and then cause toxicity to human body, which often limits their applications .…”

Section: Tumor Therapymentioning

confidence: 99%

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

Tan

Meng

2020

Adv Funct Materials

Self Cite

129

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Nanoscale metal‐organic frameworks (NMOFs) have attracted increasing attention for biomedical applications due to their large specific surface area, good biocompatibility, adjustable structures, and diverse functions. By choosing appropriate metal ions and ligands, NMOFs can be synthesized and regulated to assist the diagnosis and treatment of cancer, acting as imaging agents, drug carriers, and cancer therapeutic agents. This review summarizes the recent advances of NMOFs in synthesis, biocompatibility, imaging, and applications in cancer therapies. Among these, the term “biocompatibility” is used to outline their various biological characteristics, and it is mainly discussed from the aspects of size and surface properties of NMOFs. The imaging section mainly emphasizes the application advantages of NMOFs as imaging agents in magnetic resonance, computed tomography, and fluorescence imaging. The applications of NMOFs in four cancer therapies, including phototherapy, radiotherapy, microwave therapy, and ultrasonic therapy, are addressed, especially for thermal and dynamic therapy. Finally, the prospects and challenges of NMOFs in imaging and cancer therapies are also discussed.

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A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrO₂nanoparticles

Abstract: This paper develops a simple multifunctional theranostic platform using an IL@ZrO2 nanostructure for CT imaging guided tumor microwave thermotherapy.

Cited by 75 publications

References 38 publications

An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology

An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology

Gadolinium-doped hollow CeO₂-ZrO₂ nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

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A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrO2nanoparticles

Abstract: This paper develops a simple multifunctional theranostic platform using an IL@ZrO2 nanostructure for CT imaging guided tumor microwave thermotherapy.

Cited by 75 publications

References 38 publications

An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology

An ultra wideband-high spatial resolution-compact electric field sensor based on Lab-on-Fiber technology

Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle

Nanoscale Metal‐Organic Frameworks: Synthesis, Biocompatibility, Imaging Applications, and Thermal and Dynamic Therapy of Tumors

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Product

Resources

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A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrO₂nanoparticles

Gadolinium-doped hollow CeO₂-ZrO₂ nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle