A Small Study of the Relationship Between Abobotulinum Toxin A Concentration and Forehead Wrinkle Reduction

Abbasi, Naheed R.; Durfee, Melissa A.; Petrell, Kathleen; Dover, Jeffrey S.; Arndt, Kenneth A.

doi:10.1001/archdermatol.2011.611

Cited by 21 publications

(12 citation statements)

References 5 publications

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“…36 A recent study investigating the field of effect in 10 patients found a larger field of effect (ie, mean wrinkle reduction, 794.1 vs 486.6 mm 2 ) when a larger reconstitution volume (and hence injection volume) was used. 36 Electromyography studies show that BoNT-A can diffuse up to 3 cm from the point of injection, making accurate identification and injection of target muscles essential to achieving the desired outcome. 37 …”

Section: Resultsmentioning

confidence: 99%

Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review

Cohen

Scuderi

2017

Aesthetic Surgery Journal

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A systematic review of the published literature (from January 2000 to January 2016) to ascertain the safety of, and patient satisfaction with, the aesthetic use of abobotulinumtoxinA was conducted. In addition to the licensed indications, other special populations were considered for discussion. The potential impact of neutralizing antibodies and systemic toxicity were also addressed. A total of 364 papers were screened and 86 were found to be relevant to the population, intervention(s), and outcomes stipulated in the protocol. The safety and patient satisfaction data from these publications are discussed in this review.Level of Evidence: 2

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Section: Resultsmentioning

confidence: 99%

Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review

Cohen

Scuderi

2017

Aesthetic Surgery Journal

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“…Abbasi and colleagues 61 treated 10 patients with 2 concentrations of Dysport (6 units diluted in 0.1 mL or 0.3 mL) injected into the first prominent horizontal crease between 2.5 and 3.0 cm above the orbital rim. The more concentrated solution produced a mean wrinkle reduction of 476.6 mm 2 compared with 794.1 mm 2 using the higher volume.…”

Section: Myth 6: the Volume Of Injection Mattersmentioning

confidence: 99%

Botulinum Toxin in Aesthetic Medicine: Myths and Realities

Dover

Monheit²,

Greener³

et al. 2018

Dermatol Surg

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BACKGROUNDSeveral formulations of Botulinum toxin serotype A (BoNT-A) for aesthetic indications are available, with numbers likely to increase. Preparations are not interchangeable, based on dose unit comparisons.OBJECTIVENumerous myths and misconceptions regarding the use of BoNT-A for aesthetic indications have arisen, which this review aims to lay to rest.MATERIALS AND METHODSThis review assesses evidence for and against each of the most common myths regarding BoNT use in aesthetics.RESULTSBoNT-A neurotoxin/protein complexes are irrelevant to the toxin's therapeutic/aesthetic indications. BoNT-A neurotoxin/protein complexes do not influence movement from injection site or immunogenicity. Any relationship between neutralizing antibody formation and clinical response is complex and clinicians should consider other factors that may induce an apparent loss of clinical response. Diffusion appears predominately, perhaps exclusively, dose dependent. Careful placement and correct dosing optimizes likelihood of good outcomes. Manufacturers recommend reconstitution of products with sterile nonpreserved saline. However, compelling evidence suggests that reconstitution using preserved saline dramatically improves patient comfort without compromising efficacy. Several post-treatment instructions/restrictions are widely used despite the lack of evidence, but muscle activity after injection may be beneficial. Cooling the treatment area might hinder BoNT-A translocation and should probably be abandoned.CONCLUSIONThe existing evidence suggests that experienced users should achieve equivalent results regardless of BoNT-A formulation, but additional, well-designed, adequately powered, controlled randomized studies should be performed.

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“…The efficacy and safety has also been shown for long‐term treatment . Increasingly publications on controlled studies with respect to the treatment of forehead frown lines and “crow's feet” with BTX‐A have been published for all 3 preparations. Also rarer indications are gaining importance in the literature .…”

Section: A: General Commentsmentioning

confidence: 99%

“…Die Effektivität und Sicherheit konnte auch für Langzeitbehandlungen nachgewiesen werden [14,15,36,48]. Zunehmend erscheinen für alle 3 Präparate Publikationen über kontrollierte Studien bezüglich Behandlungen von Stirnfalten [51][52][53][54][55] und "Krähenfüße" mit BTX-A [56,57]. Auch seltenere Indikationen gewinnen in der Literatur an Bedeutung [58].…”

Section: Die Zusammensetzung Des Botulinum Neurotoxin Typunclassified

S1 guideline aesthetic botulinum toxin therapy

Imhof

Sommer²

2013

J Deutsche Derma Gesell

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A Small Study of the Relationship Between Abobotulinum Toxin A Concentration and Forehead Wrinkle Reduction

Cited by 21 publications

References 5 publications

Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review

Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review

Botulinum Toxin in Aesthetic Medicine: Myths and Realities

S1 guideline aesthetic botulinum toxin therapy

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