A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival
O. A. Arosarena,
A. S. Saribas,
E. P. Papadopoulos
Abstract:Reversible phosphorylation is the basis for signal transduction in eukaryotic cells, and this is tightly controlled by the complex interplay of kinases and phosphatases. Many malignancies are characterized by dysregulation of the delicate protein phosphorylation balance. The targeting of protein phosphatases has been gaining attention as their role in cancer development and progression has been elucidated. The protein phosphatase-2A (PP2A) family of phosphatases are the primary cellular serine/threonine phosph… Show more
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