A Small-Molecule Fluorescent Probe for the Detection of Mitochondrial Peroxynitrite
Han Dong,
Meng-Yu Tang,
Shili Shen
et al.
Abstract:Reactive oxygen species (ROS) are pivotal signaling molecules that control a variety of physiological functions. As a member of the ROS family, peroxynitrite (ONOO−) possesses strong oxidation and nitrification abilities. Abnormally elevated levels of ONOO− can lead to cellular oxidative stress, which may cause several diseases. In this work, based on the rhodamine fluorophore, we designed and synthesized a novel small-molecule fluorescent probe (DH-1) for ONOO−. Upon reaction with ONOO−, DH-1 exhibited a sign… Show more
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