A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells

Wang, Chen; Chen, Lian; Yin, Shuo; Liu, Qihai; Liu, Wei; Cao, Yilin; Cui, Lei

doi:10.1016/j.biomaterials.2009.09.086

Cited by 153 publications

(115 citation statements)

References 30 publications

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“…Cell alignment in the direction of cyclic strain; cyclic strain alone decreases the expression of SMC markers, but combination of TGF-β1 and cyclic strain increases their levels Lee et al, 2007 Human ASCs TGF-β1 and BMP-4 for 7 days, further cultivation on polyglycolic acid for 7 days, then 5% strain for 8 weeks SMC differentiation is already induced by chemical factors alone; cyclic strain further enhances the expression of SMA and calponin, and the deposition of collagen Wang et al, 2010 Cyclic strain and use of parallel microgrooves…”

Section: Cyclic Strain Parameters For Differentiation Into Smcsmentioning

confidence: 99%

The role of mechanical stimuli in the vascular differentiation of mesenchymal stem cells

Dan

Velot

Decot

et al. 2015

Journal of Cell Science

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Mesenchymal stem cells (MSCs) are among the most promising and suitable stem cell types for vascular tissue engineering. Substantial effort has been made to differentiate MSCs towards vascular cell phenotypes, including endothelial cells and smooth muscle cells (SMCs). The microenvironment of vascular cells not only contains biochemical factors that influence differentiation, but also exerts hemodynamic forces, such as shear stress and cyclic strain. Recent evidence has shown that these forces can influence the differentiation of MSCs into endothelial cells or SMCs. In this Commentary, we present the main findings in the area with the aim of summarizing the mechanisms by which shear stress and cyclic strain induce MSC differentiation. We will also discuss the interactions between these mechanical cues and other components of the microenvironment, and highlight how these insights could be used to maintain differentiation.

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Section: Cyclic Strain Parameters For Differentiation Into Smcsmentioning

confidence: 99%

The role of mechanical stimuli in the vascular differentiation of mesenchymal stem cells

Dan

Velot

Decot

et al. 2015

Journal of Cell Science

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“…In a recently published clinical trial of vascular grafts composed of autologous bone marrow aspirate seeded onto a PGA/PCL scaffold and implanted into a cohort of 25 patients presenting with single ventricle physiology, all patients were asymptomatic 30 days post implantation and 24/25 patients were alive at one year post-implantation (Hibino et al, 2010). Efforts to seed PGA tubular neo-vessel scaffolds with smooth muscle cells derived from the directed differentiation of bone marrow or adipose derived MSC with TGF- have also been described (Wang et al, 2010;Gong and Niklason, 2008). The requirement to induce directed differentiation with TGF- or related agents as well as the prolonged maturation period under pulsatile conditions needed to achieve a mature smooth muscle phenotype will likely make this approach impractical for commercial application.…”

Section: Neo-vesselmentioning

confidence: 99%

Tissue Engineering of Tubular and Solid Organs: An Industry Perspective

Basu¹,

Ludlow²

2011

Advances in Regenerative Medicine

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“…That is why polyesters have been studied for a long time [14][15][16][17][18][19][20]. A lot of efforts have been done on improving the biocompatibility of the polyester porous scaffolds [21][22][23][24][25][26][27][28], and examinations of their medical applications [27][28][29][30][31][32][33].…”

mentioning

confidence: 99%

Effects of L-lactic acid and D,L-lactic acid on viability and osteogenic differentiation of mesenchymal stem cells

Wang

Ding

2013

Chin. Sci. Bull.

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Poly(lactic acid) (PLA) and other aliphatic polyesters containing the unit of lactic acid are very popular biodegradable materials. While the degradation products, lactic acids, have been worried to bring with negative influence on biocompatibility, the focused experimental studies are less reported. This study is aimed at an in vitro examination of cytotoxicity of both L-lactic acid and D,L-lactic acid. Mesenchymal stem cells (MSCs) derived from rat bone marrow are employed to test the cytotoxicity of the lactic acids. Considering that the addition of lactic acids not only introduces lactate groups but also alters medium pH and ion strength, these three candidate effects are examined in a decoupled way by setting different comparison groups. The results confirm that the change of medium pH is the predominant factor. It has also been found that D-lactate is more cytotoxic than L-lactate at high concentrations. Yet, either L-or D,L-lactic acids seem acceptable in most of medical applications, because the cytotoxicity is significant only when the concentrations are as high as 20 mmol/L for both of them.

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A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells

Cited by 153 publications

References 30 publications

The role of mechanical stimuli in the vascular differentiation of mesenchymal stem cells

The role of mechanical stimuli in the vascular differentiation of mesenchymal stem cells

Tissue Engineering of Tubular and Solid Organs: An Industry Perspective

Effects of L-lactic acid and D,L-lactic acid on viability and osteogenic differentiation of mesenchymal stem cells

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