A Slow- Compared with a Fast-Release Form of Oral Arginine Increases Its Utilization for Nitric Oxide Synthesis in Overweight Adults with Cardiometabolic Risk Factors in a Randomized Controlled Study

Deveaux, Ambre; Fouillet, Hélène; Petzke, K. J.; Hermier, Dominique; André, Étienne; Bunouf, Pierre; Lantoine-Adam, Frédérique; Bénamouzig, Robert; Mathé, Véronique; Huneau, Jean‐François; Mariotti, François

doi:10.3945/jn.116.231910

Cited by 11 publications

(2 citation statements)

References 55 publications

(90 reference statements)

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“…For instance, the acute oral administration of arginine (9 g/day) has been shown to be not successful in inducing an effective NO production [ 216 ]. Instead, chronic administration of oral arginine (e.g., vials containing arginine salts-free 1.66 g/20 mL), has been shown to favor the utilization of arginine for NO synthesis [ 300 ], and we have data showing that oral arginine (3 g/day of Bioarginina ® , Farmaceutici Damor, 2 vials/day) improves endothelial function in hypertensive patients via the regulation of non-coding RNAs (Gambardella et al, personal communication). Large, prospective randomized clinical trials are needed to better define the target population for arginine supplementation, alongside with correct dosage definitions.…”

Section: Conclusion and Perspective: Arginine As A Therapeutic Tomentioning

confidence: 99%

Arginine and Endothelial Function

et al. 2020

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Arginine (L-arginine), is an amino acid involved in a number of biological processes, including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide production. In this systematic review, we focus on the functional role of arginine in the regulation of endothelial function and vascular tone. Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus.

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Section: Conclusion and Perspective: Arginine As A Therapeutic Tomentioning

confidence: 99%

Arginine and Endothelial Function

et al. 2020

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“…However, arginine is made available slowly from dietary proteins, which may affect its utilization for NO synthesis. In this respect, we showed in another study that in adults with the hypertriglyceridemic waist (HTW) 8 phenotype, sustained-release (SR) arginine, which mimics the kinetics of dietary arginine, was used more efficiently for NO synthesis than an immediate-release form (29). At a low level of intake, SR-arginine has been shown to improve endothelial function under fasting conditions (12).…”

Section: Introductionmentioning

confidence: 99%

L-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors

Deveaux

Pham

West

et al. 2016

The Journal of Nutrition

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Supplementation with low-dose SR-arginine alleviates postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low. The benefits of arginine supplementation may be linked to a lower ability to mobilize endogenous arginine for nitric oxide synthesis during a postprandial challenge. This trial was registered at clinicaltrials.gov as NCT02354794.

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Physically and chemically-crosslinked L-arginine-loaded polyvinyl alcohol- hyaluronic acid- cellulose nanocrystals hydrogel membranes for wound healing: influence of crosslinking methods on biological performance of membranes in-Vitro

Hussein

Kamoun

Loutfy

et al. 2023

J.Umm Al-Qura Univ. Appll. Sci.

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Two types of polyvinyl alcohol-blended hyaluronic acid and cellulose nanocrystals (PVA/HA/CNCs) hydrogels membranes were developed as delivery agents for L-arginine using chemical/and/physical crosslinking methods for exploring biological performance of the obtained membranes. Chemically and physically/crosslinked membranes were fabricated by solution-casting and freeze-thawing techniques, respectively. The characterization of the crosslinked PVA/HA/CNCs/L-arginine membranes were conducted by SEM, FTIR, TGA, swelling ratio, and in—vitro L-arginine release. Furthermore, applying two types of crosslinked membranes in vitro were investigated in terms of cytotoxicity, hemocompatibility, and cell adhesion affinity of HFB-4 cell line. Chemical and physical-crosslinked membranes were verified through the esterification and hydrogen bonds interactions, respectively as shown the FTIR spectra. The chemically-crosslinked membranes showed more thermal and mechanical stability than the physically-crosslinked ones. Besides, the chemically-crosslinked hydrogels exhibited biphasic release behavior of L-arginine reached 50% in the first hour and 92% after 48 h. Notably, chemically-crosslinked membranes a somewhat affect the cell viability %, while both crosslinked membranes exhibited excellent cell adhesion affinity and low hemolysis. However, the physically- crosslinked members showed high cell viability ~ 172%, compared to the chemically-crosslinked membranes at 98.5%; and low hemolysis ca. 0.84 versus 1.34 for chemically-crosslinked membranes. Accordingly, both types of crosslinked membranes have a potential for applying in biomedical applications, particularly for designing promising wound dressing biomaterials.

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A Slow- Compared with a Fast-Release Form of Oral Arginine Increases Its Utilization for Nitric Oxide Synthesis in Overweight Adults with Cardiometabolic Risk Factors in a Randomized Controlled Study

Cited by 11 publications

References 55 publications

Arginine and Endothelial Function

Arginine and Endothelial Function

L-Arginine Supplementation Alleviates Postprandial Endothelial Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low: A Randomized Controlled Trial in Healthy Overweight Adults with Cardiometabolic Risk Factors

Physically and chemically-crosslinked L-arginine-loaded polyvinyl alcohol- hyaluronic acid- cellulose nanocrystals hydrogel membranes for wound healing: influence of crosslinking methods on biological performance of membranes in-Vitro

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