A sleep-inducing peptide from the venom of the Indian cone snail Conus araneosus

Franklin, Jayaseelan Benjamin; Rajesh, Rajaian Pushpabai

doi:10.1016/j.toxicon.2015.06.017

Cited by 12 publications

(7 citation statements)

References 41 publications

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“…924 Dolastatin 16 obtained by total synthesis 925 was found to be inactive, in contrast to the potent cytotoxicity towards HTCLs originally attributed to the MNP (Dolabella auricularia). 926 New examples of M-and Tsuperfamily peptides were isolated from Indian collections of Conus araneosus 927 and C. gulinus 928 while analysis of venom duct cDNA from C. litteratus 929 and C. marmoreus 930 prompted the cloned expression or chemical synthesis and subsequent biological evaluation of new peptides. Highly detailed transcriptome analysis of C. episcopatus identied over 3300 novel full-length conotoxin precursors which represented 9 known and 16 new gene superfamilies.…”

Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2017

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“…In contrast to the marine compounds affecting the nervous system with investigated mechanisms of action discussed above, and as shown in Table 2, for marine compounds (120, 121, 212-218), only an IC 50 was reported, but the molecular mechanism of action of these compounds remained undetermined at the time of publication: an Australian marine-sponge Aplysinella sp.-derived aplysinellamide-1 (212) [229], the novel lactones territrem D, and arisugacin A (120, 121) from a fungus Aspergillus terreus SCSGAF0162 derived from a South China sea gorgonian Echinogorgia aurantiaca [115]; an Indian marine cone snail Conus araneosus ar3j peptide (213) [230]; a new steroid (214) from a fungus Dichotomomyces cejpii isolated from an Australian marine sponge Callyspongia cf. C. flammea [231]; a novel genuanine (215) isolated from Cape Verde marine cone snail Conus genuanus [232]; a bromotyrosine alkaloid homoaerothionin (216) isolated from the Thai sponge Acanthodendrilla sp.…”

Section: Marine Compounds Affecting the Nervous Systemmentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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“…These are known as “sleeper” peptides because they induce sleep. Franklin et al [86] extracted peptides from the venom ducts of the Indian cone snail Conus araneosus by squeezing and extracting venom with 50% acetonitrile. After extracting the crude sample, it was subjected to RP-HPLC and mass chromatography, and 14 peptides were isolated.…”

Section: Classification Of Marine Resourcesmentioning

confidence: 99%

“…Among these, three peptide sequences, namely, ar3g, ar3h, and ar3i, exhibited posttranslational modifications. One of these peptides was evaluated for sleep-inducing activity in a mouse model [86]. …”

Section: Classification Of Marine Resourcesmentioning

confidence: 99%

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Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

2017

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Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity. Although marine resources provide thousands of possible peptides, only a few peptides derived from marine sources have reached the pharmaceutical market. This review focuses on some of the peptides derived from marine sources in the past ten years and gives a brief review of those that are currently in clinical trials or on the market.

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A sleep-inducing peptide from the venom of the Indian cone snail Conus araneosus

Cited by 12 publications

References 41 publications

Marine natural products

Marine natural products

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

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