A skeletal case of hypertrophic osteoarthropathy from the Canary Islands dating from 1000 BP

González‐Reimers, Emilio; Trujillo-Mederos, Aioze; Machado-Calvo, Manuel; Castañeyra-Ruiz, María; Ordóñez, Alejandra C.; Rosa, Manuel Antonio González de la

doi:10.1016/j.ijpp.2015.07.001

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…Furthermore, 40% of patients show absorption of terminal phalanges on radiology 8 , resulting from the expression of a phosphateregulating gene with homologies to endopeptidase on the X chromosome (PHEX) that facilitates suppression by M. leprae in osteoblasts 9 . Other authors, however, have reported nding bone formation in patients with leprosy 10 . Tolllike receptor (TLR)1 and TLR4 polymorphisms are associated with protection against leprosy 11,12 , and mineralizationrelated protein is elevated in the condition 13 .…”

Section: Introductionmentioning

confidence: 91%

A Comprehensive Analysis of the circRNA–miRNA–mRNA Network in Osteocyte-Like Cell Associated with Mycobacterium Leprae Infection

Zhengrong¹,

Liu²,

Zhao³

et al. 2021

Preprint

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Bone formation and loss are the characteristic clinical manifestations of leprosy, but the mechanisms underlying the bone remodeling with Mycobacterium leprae (M. leprae) infection are unclear. Osteocytes may have a role through regulating the differentiation of osteogenic lineages. To investigate osteocyte-related mechanisms in leprosy, we treated osteocyte-like cell with N-glycosylated muramyl dipeptide (N.g MDP). RNA-seq analysis showed 724 differentially expressed messenger RNAs (mRNAs) and 724 differentially expressed circular RNA (circRNAs). Of these, we filtered through eight osteogenic-related differentially expressed genes, according to the characteristic of competing endogenous RNA, PubMed databases, and bioinformation analysis, including TargetScan, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes. Based on these results, we built a circRNA–microRNA (miRNA)–mRNA triple network. Quantitative reverse-transcription polymerase chain reaction and western blots analyses confirmed decreased Clock expression in osteocyte-like cell, while increased in bone mesenchymal stem cells (BMSCs), implicating a crucial factor in osteogenic differentiation. Immunohistochemistry showed obviously increased expression of CLOCK protein in BMSCs and osteoblasts in N.g MDP–treated mice, but decreased expression in osteocytes. This analytical method provided a basis for the relationship between N.g MDP and remodeling in osteocytes, and the circRNA–miRNA–mRNA triple network may offer a new target for leprosy therapeutics.

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Section: Introductionmentioning

confidence: 91%

A Comprehensive Analysis of the circRNA–miRNA–mRNA Network in Osteocyte-Like Cell Associated with Mycobacterium Leprae Infection

Zhengrong¹,

Liu²,

Zhao³

et al. 2021

Preprint

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“…As Fennel and Trinkaus established, the bilateral periostitis present on the femurs and tibiae of LF1 is consistent with HOA [ 7 ]. Researchers have used similar radiological techniques to identify HOA-afflicted human remains from 1970 [ 9 ], medieval England [ 10 ], the Canary Islands roughly a millennium old [ 11 ], and Iron Age civilization [ 12 ]. While it is impossible to fully determine the diagnosis of secondary HOA, given that LF1 displays no soft tissue preservation, it appears highly likely that LF1 did experience this syndrome from an underlying pathology, theorized by Fennel and Trinkaus to be either a thoracic infection or a carcinoma [ 7 ].…”

Section: Reviewmentioning

confidence: 99%

“…Healthcare behaviors can be traced even earlier - H. habilis from 2.4-1.6 million years before the present day often have evidence of deep grooves in their teeth, and wood fragments present in their dental calculus, possibly from the use of makeshift toothpicks to treat periodontal disease [ 18 ]. Many Neanderthal teeth express the same pattern of interproximal grooves, indicating dental probing [ 5 , 11 ]. In addition to this, the Neanderthals may have even used medicinal plants.…”

Section: Reviewmentioning

confidence: 99%

Possible Causes of Hypertrophic Osteoarthropathy in the La Ferrassie 1 Neanderthal

Turner¹

2023

Cureus

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For over a century, researchers have been perplexed by the unique osteological findings on La Ferrassie 1 (LF1), one of the most complete Neanderthal remains ever found. In 1997, Fennel and Trinkaus proposed that LF1 suffered from hypertrophic osteoarthropathy (HOA), likely secondary to chronic thoracic infection or pulmonary malignancy. This disease process can have many etiologies, and no study has fully explored the possible origin of LF1's HOA. Ultimately, it is most likely that LF1's HOA etiology arose from one of the many infectious diseases that prehistoric Neanderthals were exposed to, specifically a chronic pulmonary RNA virus.

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“…leprae in osteoblasts [ 9 ]. Other authors, however, have reported finding bone formation in patients with leprosy [ 10 ]. Toll-like receptor (TLR)1 and TLR4 polymorphisms are associated with protection against leprosy [ 11 , 12 ], and mineralization-related protein is elevated in the condition [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive analysis of the circRNA–miRNA–mRNA network in osteocyte-like cell associated with Mycobacterium leprae infection

et al. 2022

View full text Add to dashboard Cite

Background Bone formation and loss are the characteristic clinical manifestations of leprosy, but the mechanisms underlying the bone remodeling with Mycobacterium leprae (M. leprae) infection are unclear. Methodology/Principal findings Osteocytes may have a role through regulating the differentiation of osteogenic lineages. To investigate osteocyte-related mechanisms in leprosy, we treated osteocyte-like cell with N-glycosylated muramyl dipeptide (N.g MDP). RNA-seq analysis showed 724 differentially expressed messenger RNAs (mRNAs) and 724 differentially expressed circular RNA (circRNAs). Of these, we filtered through eight osteogenic-related differentially expressed genes, according to the characteristic of competing endogenous RNA, PubMed databases, and bioinformatic analysis, including TargetScan, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes. Based on these results, we built a circRNA–microRNA (miRNA)–mRNA triple network. Quantitative reverse-transcription polymerase chain reaction and western blots analyses confirmed decreased Clock expression in osteocyte-like cell, while increased in bone mesenchymal stem cells (BMSCs), implicating a crucial factor in osteogenic differentiation. Immunohistochemistry showed obviously increased expression of CLOCK protein in BMSCs and osteoblasts in N.g MDP–treated mice, but decreased expression in osteocytes. Conclusions/Significance This analytical method provided a basis for the relationship between N.g MDP and remodeling in osteocytes, and the circRNA–miRNA–mRNA triple network may offer a new target for leprosy therapeutics.

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A skeletal case of hypertrophic osteoarthropathy from the Canary Islands dating from 1000 BP

Cited by 9 publications

References 40 publications

A Comprehensive Analysis of the circRNA–miRNA–mRNA Network in Osteocyte-Like Cell Associated with Mycobacterium Leprae Infection

A Comprehensive Analysis of the circRNA–miRNA–mRNA Network in Osteocyte-Like Cell Associated with Mycobacterium Leprae Infection

Possible Causes of Hypertrophic Osteoarthropathy in the La Ferrassie 1 Neanderthal

A comprehensive analysis of the circRNA–miRNA–mRNA network in osteocyte-like cell associated with Mycobacterium leprae infection

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