A Six-Year Prospective Study of the Prognosis and Predictors in Patients With Late-Life Depression

Jeuring, Hans W.; Stek, Max L.; Huisman, Martijn; Voshaar, Richard C. Oude; Naarding, Paul; Collard, Rose M.; Mast, Roos C. van der; Kok, Rob; Beekman, Aartjan; Comijs, Hannie C.

doi:10.1016/j.jagp.2018.05.005

Cited by 46 publications

(45 citation statements)

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“…Several studies have reported that women often show higher scores in neuroticism than men (Lynn & Martin, ; Weisberg et al, ). At the same time, higher neuroticism scores have been related to some affective disorders (Ormel et al, ) and an unfavorable course of them (Jeuring et al, ; Struijs et al, ). These data agree with the results present herein that show a negative correlation between emotional stability (and its subdimensions) and anxiety and depression levels.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported that women often show higher scores in neuroticism than men (Lynn & Martin, 1997;Weisberg et al, 2011). At the same time, higher neuroticism scores have been related to some affective disorders and an unfavorable course of them (Jeuring et al, 2018;Struijs et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The magnitude of these differences become fewer with age, although a small difference is present even in old age (Chapman, Duberstein, Sörensen, & Lyness, 2007;Soto, John, Gosling, & Potter, 2011). Higher neuroticism scores have been related to some of the most common mental disorders, including mood, anxiety, and substance use disorders , and with an unfavorable course of them (Jeuring et al, 2018;Struijs, Lamers, Spinhoven, van der Does, & Penninx, 2018). The higher scores in neuroticism of women respect to men have been related to the fact that women have higher incidence of anxious and depressive disorders than men (Alonso et al, 2004;Riecher-Rössler, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

et al. 2019

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Background Neuroticism is associated with low emotional stability, and it is characterized by a tendency to perceive ordinary situations as threatening and difficult to manage. This personality trait has been associated with psychological distress and predicts some mental disorders. Previous studies have shown that women tend to be more neurotic than men and, in general, females have also a higher incidence of anxious and depressive disorders. Methods We analyzed in a sample of 99 female university students (from 18 to 26 years old) if emotional stability, measured using the Big Five Questionnaire, was linked to polymorphic variants in candidate genes related to dopaminergic and serotonergic systems, and other personality variables. Results We found that emotional stability and its subdimensions are genetically associated with MAOA‐uVNTR polymorphism. Thus, women carriers of the 3‐repeat allele (lower MAO‐A expression) showed higher levels of emotional stability. No associations were found with other polymorphisms analyzed, including COMT Val158Met, 5‐HTTLPR, and DAT 3′UTR VNTR. Furthermore, our results showed a negative correlation between emotional stability and depression, state anxiety, and trait anxiety. In fact, MAOA‐uVNTR and trait anxiety also explained emotional stability and its subdimensions. We also found that other genetic characteristic, phenylthiocarbamide tasting, explained impulsivity, specifically tasters controlled impulses better than nontasters. Conclusion Our results indicate that neuroticism might be regulated by MAOA and could be a common factor between different phenotypes, such as aggressive behaviors or personality disorders, observed in women with higher activity genotype who had been exposed to negative environments during childhood. This study could lead to a better understanding of the basis of emotional stability and could lead to future projects for this purpose.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

et al. 2019

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“…Longitudinal studies provide evidence for both SI/L as antecedent risk factors for incident depression or worsening late-life depression in older adults. 16 , 52 , 53 Notably, a study of over 11,000 older U.S. adults found that lower frequency of in-person social contacts was related to higher rates of depression over 2 years. 54 Lower frequencies of telephone, written or email contacts were unrelated to future depression, pointing to a specific salutary impact of in-person contacts.…”

Section: Definitionsmentioning

confidence: 99%

Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report

Donovan

Blazer

2020

The American Journal of Geriatric Psychiatry

254

190

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Highlights This article provides a comprehensive review of the recent National Academies of Science, Engineering and Medicine consensus committee report on Social Isolation and Loneliness (SI/L). The relevance specifically for mental health providers is emphasized. What is the primary question addressed by this study?What are the physical and mental health consequences of SI/L? What are the current evidence-based interventions for SI/L which can be implemented by mental health professionals? SI/L are significant public health problems and are clear risks for death, depression, anxiety, and cognitive disorders such as major cognitive impairment (dementia). The evidence based interventions by mental health professionals for SI/L are limited yet some have emerged which are promising. Health and mental healthcare professionals may be the first to identify socially isolated and lonely older adults as these older adults are at significant increased risk for serious adverse outcomes. For this reason, these professionals should know how to screen for and to initiate interventions that can be helpful.

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“… 8 It also has profound effects on mental health. A commonly reported association exists between loneliness and depression, with some evidence that feelings of loneliness exacerbate later depressive symptoms, 9 , 10 , 11 though the relationships may be bidirectional. 12 , 13 , 14 Links also exist between social disconnection and a number of other mental illnesses, including anxiety, 13 , 15 , 16 psychosis, 17 , 18 obsessive compulsive disorder, 19 borderline personality disorder, 20 , 21 and post-traumatic stress disorder.…”

mentioning

confidence: 99%

Social Disconnection in Late Life Mental Illness – Commentary From the National Institute of Mental Health

Necka

Rowland

Evans

2021

The American Journal of Geriatric Psychiatry

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Highlight Social disconnection – both objective social isolation as well as perceived social isolation (otherwise known as loneliness) – is a prevalent affliction among older adults, with profound effects on mental health. Mechanistic understanding of how mental illness contributes to, is exacerbated by, or is otherwise linked to social disconnection remains elusive, and therapeutic interventions which leverage social connection to enhance compliance with or efficacy of mental health treatment, though promising, remain scarce. The National Institute of Mental Health (NIMH) is committed to transforming the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. To translate basic knowledge into new methods for diagnosis, treatment, and prevention of mental illness demands appreciation for the broader milieu of social and environmental factors in which mental illness prevails – of which, social connection or disconnection is one.

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A Six-Year Prospective Study of the Prognosis and Predictors in Patients With Late-Life Depression

Abstract: The long-term prognosis of late-life depression is poor with regard to mortality and course of depression. Chronic diseases, loneliness, and pain may be used as putative targets for optimizing prevention and treatment strategies for relapse and chronicity.

Cited by 46 publications

References 50 publications

Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report

Social Disconnection in Late Life Mental Illness – Commentary From the National Institute of Mental Health

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