A singlet oxygen self-reporting photosensitizer for cancer phototherapy

Abstract

Photodynamic cancer therapy has attracted great attentions with the increasing threatens of tumors, and improving its therapeutic efficacy is highly desirable. However, due to the highly-efficient intersystem crossing potency to...

Highly selective generation of singlet oxygen from dioxygen with atomically dispersed catalysts

“…According to the results demonstrated above, such capacity of killing cancer cells was deemed to originate from the intracellular oxidative stress induced by Fe 1 /HNC SAC-enabled selective production of 1 O 2 , which was distinctly conrmed with a cell-permeable ROS-sensitive probe (2 0 ,7 0 -dichlorouorescein diacetate, DCFH-DA). 63,64 Obviously, cancer cells treated with P-Fe 1 /HNC show the brightest green uorescence of DCF (Fig. 5d and S28 †), indicative of most 1 O 2 generation enabled by Fe 1 /HNC.…”

Cell nucleus localization and high anticancer activity of quinoline–benzopyran rhodium(iii) metal complexes as therapeutic and fluorescence imaging agents

“…2), which differs from previous studies on the biological behavior of rhodium fluorescent compounds. 16,27–31,63 As measured by confocal microscopy, the contents of Rh( iii ) for RhQ (0.08 μM) in the nuclei were significantly higher than that of the mitochondria and cytosol (Fig. 2).…”

Strong π–π Stacking Stabilized Nanophotosensitizers: Improving Tumor Retention for Enhanced Therapy for Large Tumors in Mice

“…To determine whether the AN‐BDP is able to generate ROS under red‐light irradiation, 1,3‐diphenyliso‐benzofuran (DPBF) was used as an indicator. [ 17 ] As demonstrated by the DPBF depolarization curves, the irradiation of AN‐BDP with a 630 nm red light resulted in a decrease of the probe absorption, suggesting a favorable ROS generation capacity for AN‐BDP . The ROS was further validated by electron paramagnetic resonance (EPR) spectroscopy.…”

“…The mechanism of AN‐BDP NPs‐mediated PDT was evaluated using 2,7‐dichlorodihydrofluorescein diacetate (DCFH‐DA), a standard fluorescent ROS probe indicator in living cells (Figure 3c). [ 17 ] Compared to the control group, under 630 nm illumination, the AN‐BDP NPs‐treated 4T1 cells displayed bright green fluorescence indicating that ROS was effectively generated. Conversely, in the group without light or NPs, no green fluorescence was detectable.…”