A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic Responses

Scott, Dorothy E.; Golding, Basil

doi:10.1007/978-1-4899-0062-3_8

Vaccine Design 1997

DOI: 10.1007/978-1-4899-0062-3_8

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A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic Responses

Dorothy E. Scott

Basil Golding

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2001

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“…Heatkilled B. abortus (HKBA) has been shown to up-regulate the secretion of IL-12 and IFN-␥ (2,12,21) and is considered a strong Th1 stimulus (2,19). We have recently demonstrated that a single injection of B. abortus, when injected together with ovalbumin adsorbed to alum (OVA-A) into adult mice, has the ability to abolish antigen-specific IgE-mediated allergic responses to repeated OVA-A challenge and to increase production of IgG2a in vivo (12,13). This effect of B. abortus on isotype switching correlated with an increase in IFN-␥ and a decrease in IL-4-secreting-cells (12).…”

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Ontogeny of Th1 Memory Responses against aBrucella abortusConjugate

et al. 2001

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Protective immune responses to intracellular pathogens such as Brucella abortus are characteristically Th1-like. Recently we demonstrated that heat-killed B. abortus (HKBa), a strong Th1 stimulus, conjugated to ovalbumin (HKBA-OVA), but not B. abortus alone, can alter the antigen-specific cytokine profile from Th2-to Th1-like. In this report we study the ability of a single injection of B. abortus to switch a Th2 to a Th1 response in immature mice. One-day-and 1-week-old mice were given a single injection of B. abortus in the absence or presence of OVA, and at maturity mice were challenged with an allergenic preparation, OVA with alum (OVA-A). B. abortus given without OVA did not diminish the subsequent Th2 response in either age group. In contrast, mice receiving a single injection of B. abortus-OVA at the age of 1 week, but not those injected at the age of 1 day, had reversal of the ratio of OVA-specific Th1 to Th2 cells and decreased immunoglobulin E levels after allergen challenge as adults. Within 6 h both 1-day-and 1-week-old mice expressed interleukin-12 p40 mRNA following either B. abortus or B. abortus-OVA administration. However, only the 1-week-old mice exhibited increased expression of gamma interferon (IFN-␥) mRNA. The absence of the early IFN-␥ response in 1-day-old mice may explain their inability to generate a Th1 memory response. These results suggest that at early stages of immune development, responses to intracellular bacteria may be Th2-rather than Th1-like. Furthermore, they suggest that the first encounter with antigen evokes either a Th1-or a Th2-like response which becomes imprinted, so that subsequent memory responses conform to the original Th bias. This has implications for protection against infectious agents and development of allergic responses.

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confidence: 99%

Ontogeny of Th1 Memory Responses against aBrucella abortusConjugate

et al. 2001

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A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic Responses

Cited by 1 publication

References 51 publications

Ontogeny of Th1 Memory Responses against aBrucella abortusConjugate

Ontogeny of Th1 Memory Responses against aBrucella abortusConjugate

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