Vaccine Design 1997
DOI: 10.1007/978-1-4899-0062-3_8
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A Single Treatment with Adjuvant Stimulates Th1-Like Cytokines and Downregulates Th2-Mediated Primary and Secondary Allergic Responses

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“…Heatkilled B. abortus (HKBA) has been shown to up-regulate the secretion of IL-12 and IFN-␥ (2,12,21) and is considered a strong Th1 stimulus (2,19). We have recently demonstrated that a single injection of B. abortus, when injected together with ovalbumin adsorbed to alum (OVA-A) into adult mice, has the ability to abolish antigen-specific IgE-mediated allergic responses to repeated OVA-A challenge and to increase production of IgG2a in vivo (12,13). This effect of B. abortus on isotype switching correlated with an increase in IFN-␥ and a decrease in IL-4-secreting-cells (12).…”
mentioning
confidence: 99%
“…Heatkilled B. abortus (HKBA) has been shown to up-regulate the secretion of IL-12 and IFN-␥ (2,12,21) and is considered a strong Th1 stimulus (2,19). We have recently demonstrated that a single injection of B. abortus, when injected together with ovalbumin adsorbed to alum (OVA-A) into adult mice, has the ability to abolish antigen-specific IgE-mediated allergic responses to repeated OVA-A challenge and to increase production of IgG2a in vivo (12,13). This effect of B. abortus on isotype switching correlated with an increase in IFN-␥ and a decrease in IL-4-secreting-cells (12).…”
mentioning
confidence: 99%