Abstract:The envelope stress response (ESR) of Gram-negative enteric bacteria senses fluctuations in nutrient availability and environmental changes to avert damage and promote survival. It has a protective role towards antimicrobials but direct interactions between ESR components and antibiotic resistance genes have not been demonstrated. Here we report specific interactions between the two-component conjugative pilus expression (Cpx)RA signal transduction system and the recently described mobile colistin resistance (… Show more
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