A single plasma sample method for estimation of the glomerular filtration rate in infants and children using iohexol, I: establishment of a body weight-related formula for the distribution volume of iohexol

Stake, G; Monclair, Tom

doi:10.1080/00365519109091624

Cited by 39 publications

(17 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The standard sampling time recommended by the British Nuclear Medicine Society when determining single sample clearance using nuclear medicine markers is 180–240 minutes . Other human studies have reported an optimal sampling time of 180 minutes . It is recommended, however, that in patients with a very low GFR, the sampling time is delayed.…”

Section: Discussionmentioning

confidence: 99%

“…The prediction formula for ECFV derived in this study was not found to provide a particularly accurate prediction based on the results of the agreement analysis. However, several human studies have shown that an error of up to 50% in the prediction of ECFV will not result in significant error in the clearance estimation if the timing of the sample collection is appropriate . Errors of the magnitude that may be expected to be encountered when calculating single‐sample clearance using ECFV Predicted would not be so great as to be considered clinically significant.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Single Sample Method for Estimating Glomerular Filtration Rate in Cats

Finch

Heiene

Elliott

et al. 2013

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Validated methods of estimating glomerular filtration rate (GFR) in cats requiring only a limited number of samples are desirable.Hypothesis/Objectives: To test a single sample method of determining GFR in cats. Animals: The validation population (group 1) consisted of 89 client-owned cats (73 nonazotemic and 16 azotemic). A separate population of 18 healthy nonazotemic cats (group 2) was used to test the methods.Methods: Glomerular filtration rate was determined in group 1 using corrected slope-intercept iohexol clearance. Single sample clearance was determined using the Jacobsson and modified Jacobsson methods and validated against slope-intercept clearance. Extracellular fluid volume (ECFV) was determined from slope-intercept clearance with correction for the 1 compartment assumption and by deriving a prediction formula for ECFV (ECFV Predicted ) based on the body weight. The optimal single sample method was tested in group 2.Results: A blood sample at 180 minutes and ECFV Predicted were optimal for single sample clearance. Mean AE SD GFR in group 1 determined using the Jacobsson and modified Jacobsson formulae was 1.78 AE 0.70 and 1.65 AE 0.60 mL/min/kg, respectively. When tested in group 2, the Jacobsson method overestimated multisample clearance. The modified Jacobsson method (mean AE SD 2.22 AE 0.34 mL/min/kg) was in agreement with multisample clearance (mean AE SD 2.19 AE 0.34 mL/ min/kg).Conclusions and Clinical Importance: The modified Jacobsson method provides accurate estimation of iohexol clearance in cats, from a single sample collected at 180 minutes postinjection and using a formula based on the body weight to predict ECFV. Further validation of the formula in patients with very high or very low GFR is required.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Single Sample Method for Estimating Glomerular Filtration Rate in Cats

Finch

Heiene

Elliott

et al. 2013

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Pharmacokinetic data regarding contrast media in children is limited [3,7]. However, the pharmacokinetic pro- files of several iodinated radiographic contrast agents are well described in adults [5,9,10,11].…”

Section: Discussionmentioning

confidence: 99%

Iodixanol Pharmacokinetics in Children

et al. 2001

View full text Add to dashboard Cite

The objective of this report was to study the elimination pharmacokinetics of iodixanol in children. Iodixanol (Visipaque, Nycomed Inc., Wayne, PA, USA) is a new iso-osmolar iodinated radiocontrast agent. We hypothesized that elimination of this agent would be dependent on age-related differences in renal clearance. Seven centers enrolled 43 patients. Cardiac catheterization was performed in 41 patients and cranial computed tomography in 2. Patients were entered into 5 age groups: newborn to <2 months, 2 to <6 months, 6 months to <1 year, 1 to <3 years, and 3 to 6 months of age that is comparable to normal adults. Prolonged elimination in children <6 months of age is related to renal immaturity.

show abstract

“…GFR was normalized to 1.73 m 2 body surface area (BSA) by the ratio 1.73/BSA, using the formula of Haycock et al [ 25 ]. The GFR1p was calculated with six different formulas: the Fleming formula [ 22 ], the Ham and Piepsz formula (Ham&Piepsz; [ 26 ], the Stake formula [ 13 , 21 ], the Groth and Aasted formula (Groth&Aasted; [ 20 ]), the Jacobsson formula [ 12 ] and a modification of Jacobsson’s formula (GFR1p-Jacobsson-mod.) [ 14 , 17 ] which is based on performing only the first step in Jacobsson’s three-step GFR calculation.…”

Section: Methodsmentioning

confidence: 99%

“…2 Plot of estimation error versus time point for glomerular filtration rate (GFR) calculated at five time points, stratified by estimation method ( n = 96 children). The y -axis shows the difference between the single-point GFR [ 12 , 13 , 17 , 20 , 22 , 26 ] and a reference GFR based on seven sampling time points. Each point corresponds to a combination of patient, estimation method and sample time.…”

Section: Methodsmentioning

confidence: 99%

Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times

et al. 2017

View full text Add to dashboard Cite

BackgroundThe non-ionic agent iohexol is increasingly used as the marker of choice for glomerular filtration rate (GFR) measurement. Estimates of GFR in children have low accuracy and limiting the number of blood-draws in this patient population is especially relevant. We have performed a study to evaluate different formulas for calculating measured GFR based on plasma iohexol clearance with blood sampling at only one time point (GFR1p) and to determine the optimal sampling time point.MethodsNinety-six children with chronic kidney disease (CKD) stage 1–5 (median age 9.2 years; range 3 months to 17.5 years) were examined in a cross-sectional study using iohexol clearance and blood sampling at seven time points within 5 h (GFR7p) as the reference method. Median GFR7p was 66 (range 6–153) mL/min/1.73 m2. The performances of six different single time-point formulas (Fleming, Ham and Piepsz, Groth and Aasted, Stake, Jacobsson- and Jacobsson-modified) were validated against the reference. The two-point GFR (GFR2p) was calculated according to the Jødal and Brøchner–Mortensen formula.ResultsThe GFR1p calculated according to Fleming with sampling at 3 h (GFR1p3h-Fleming) had the best overall performance, with 82% of measures within 10% of the reference value (P10). In children with a GFR ≥ 30 mL/min/1.73 m2 (n = 78), the GFR1p3h-Fleming had a P10 of 92.3%, which is not significantly different (p = 0.29) from that of GFR2p (P10 = 96.2%). Considerable differences within and between the different formulas were found for different CKD stages and different time points for blood sampling.ConclusionsFor determination of mGFR in children with CKD and an assumed GFR of ≥ 30 mL/min/1.73 m2 we recommend GFR1p3h-Fleming as the preferred single-point method as an alternative to GFR2p. For children with a GFR < 30 mL/min/1.73 m2, we recommend the slope-GFR with at least two blood samples. Clinical Trial Registration: ClinicalTrials.gov, Identifier NCT01092260, https://clinicaltrials.gov/ct2/show/NCT01092260?term=tondel&rank=2

show abstract

A single plasma sample method for estimation of the glomerular filtration rate in infants and children using iohexol, I: establishment of a body weight-related formula for the distribution volume of iohexol

Cited by 39 publications

References 18 publications

A Single Sample Method for Estimating Glomerular Filtration Rate in Cats

A Single Sample Method for Estimating Glomerular Filtration Rate in Cats

Iodixanol Pharmacokinetics in Children

Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times

Contact Info

Product

Resources

About