1993
DOI: 10.1192/bjp.163.2.166
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A Single Photon Emission Computerised Tomography Study of Regional Brain Function Underlying Verbal Memory in Patients with Alzheimer-Type Dementia

Abstract: Ten patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime. The baseline condition involved repetition of the word 'yes' or 'no'. The activation condition involved recognition (indicated by a 'yes' or 'no') of words from a previously learned list presented along with distractor words. Patients who performed this task successfully were selected, and efforts were made to match the patients with controls according to their p… Show more

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Cited by 33 publications
(13 citation statements)
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“…The results of the present study confirm the results of other authors, who observed activation of the prefrontal cortex, anterior cingulum, and parietal cortex during memory retrieval using comparable study designs [Riddle et al, 1993;Tulving et al, 1994a;Andreasen et al, 1995a;Buckner et al, 1995;Fletcher et al, 1995Grady et al, 1995;Schacter et al, 1996Schacter et al, , 1997. The present results are in accordance with findings reported in the literature suggesting a role of the anterior cingulate gyrus in memory-associated tasks.…”
Section: Recognitionsupporting
confidence: 96%
See 1 more Smart Citation
“…The results of the present study confirm the results of other authors, who observed activation of the prefrontal cortex, anterior cingulum, and parietal cortex during memory retrieval using comparable study designs [Riddle et al, 1993;Tulving et al, 1994a;Andreasen et al, 1995a;Buckner et al, 1995;Fletcher et al, 1995Grady et al, 1995;Schacter et al, 1996Schacter et al, , 1997. The present results are in accordance with findings reported in the literature suggesting a role of the anterior cingulate gyrus in memory-associated tasks.…”
Section: Recognitionsupporting
confidence: 96%
“…The left prefrontal cortex has been the most consistently reported region of activation for the different encoding tasks. The following brain areas were activated during retrieval: bilateral precuneus and right prefrontal cortex [Shallice et al, 1994;Fletcher et al, 1995], left prefrontal region, right frontal cortex, biparietal cortices, and cerebellum [Andreasen et al, 1995a]; anterior right prefrontal cortex [Buckner et al, 1995]; dorsolateral prefrontal cortex and anterior cingulate gyrus [Riddle et al, 1993]; prefrontal lobes [Schacter et al, 1996[Schacter et al, , 1997; parahippocampal areas [Schacter et al, 1995]; and areas v1 and v2 of the occipital lobes [Le Bihan et al, 1993].…”
Section: Brain Structures Involved In Memory Tasksmentioning
confidence: 99%
“…ECT could affect memory storage in several ways. The treatment might erase memories or disproportionately affect some elements of memory such as autobiographic data by interfering to a different extent with the various circuits of the human memory system (37,38). In addition, ECT could affect delayed and immediate recall to a different extent and influence the accuracy of memory storage, possibly creating pseudomemories.…”
Section: Discussionmentioning
confidence: 99%
“…[15][16][17] Several functional imaging studies have also examined brain activity patterns in Alzheimer patients and healthy controls during the performance of memory activation paradigms, using PET, SPECT, or functional MRI. [18][19][20][21][22][23][24] These studies have often employed tasks involving episodic memory retrieval processes, which in healthy subjects engage a distributed network of regions including the medial temporal, prefrontal, and lateral parietal cortices, as well as the precuneus, cingulate gyrus, and cerebellum. 25 In Alzheimer patients, activation of the medial temporal region during memory tasks is infrequent.…”
mentioning
confidence: 99%