A single, peri-operative antibiotic can persistently alter the post-operative gut microbiome after Roux-en-Y gastric bypass

Fernando, Deemantha G.; Saravia, Fatima L.; Atkinson, Samantha N; Barron, Matthew; Kirby, John R.; Kindel, Tammy L.

doi:10.1007/s00464-022-09387-4

Cited by 2 publications

(1 citation statement)

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“…This study demonstrates that relatively small differences in bacterial composition within pitchers can have functional consequences for nutrient cycling from captured prey and nutrient supply to host plants. Similar patterns are emerging from human microbiome research, where surgery or drug dosage can alter gut bacterial composition, causing cascading shifts in bacterial functions which influence host health (91). These findings underscore the relationship between bacterial community composition and function, and that functional differences are not solely dictated by composition.…”

Section: Discussionmentioning

confidence: 70%

Microbial community function increases host plant leaf growth in a pitcher plant experimental system

Bernardin,

Young,

Gray

et al. 2024

Preprint

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Across diverse ecosystems, bacteria and their host organisms engage in complex relationships having negative, neutral, or positive effects. However, the specific effects of leaf-associated bacterial community functions on plant growth are poorly understood. This study investigated mechanistic relationships between bacterial community function and host plant growth in a carnivorous plant that relies on microbes to break down insect prey via extracellular hydrolytic enzymes. Sterile, freshly opened leaves (pitchers) of purple pitcher plants (Sarracenia purpurea) were inoculated with three functionally distinct bacterial communities to test the effects of bacterial function on plant growth and leaf nutrient content. Bacterial community composition and function were measured using physiological assays, metagenomics, and metatranscriptomics. Distinct bacterial functions affected plant traits, with a bacterial community enriched in decomposition and secondary metabolite production traits leading to leaves with almost double the biomass of control pitchers. Functional differences in bacterial communities, measured by physiological assays, were supported by metatranscriptomic analysis; for example, the bacterial community with the highest chitinase activity had greater relative abundance of transcripts associated with chitinase enzymes. The bacterial community associated with larger pitchers also had increased differential expression of transcripts linked to microbially-produced plant hormones. The direct relationship between bacterial community function and plant growth observed, indicates specific mechanisms for host-associated bacterial functions to support plant health and growth.

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Section: Discussionmentioning

confidence: 70%