A Single or Split Dose Picosulphate/Magnesium Citrate Before Colonoscopy: Comparison Regarding Tolerance and Eficacy with Polyethylene Glycol. A Randomized Trial

Abstract

Background & Aims: To compare the eficacy and tolerance of sodium picosulphate/magnesium citrate(PMC) and polyethylene glycol (PEG) in a single or split dose regimen for colonoscopy bowel preparation.Methods: A prospective, randomized, endoscopist-blinded, multicenter study. The patients were randomly assigned to receive PMC (PMC4/0) or PEG (PEG4/0) in a single dose 4L day before colonoscopy or a split dose 2+2L PMC (PMC2/2) or 3+1L PEG (PEG3/1) one day before and in the morning before the colonoscopy. Each patient was interviewed to determine his/her subjective tolerance of the preparation before the procedure. The quality of bowel cleansing was assessed in a blinded test performed by multiple endoscopists using the Aronchick scale.Results: A total of 600 patients were enrolled, 88.2% were included in the analysis. Satisfactory bowel cleansing (Aronchick score 1 and 2) was signicantly more frequent when a split dose was used irrespective of the solution type (81.6% PMC2/2, 87.3% PEG3/1 vs. 73.0% PEG4/0, p = 0.024). In single dose regimens, PMC performed better than PEG (82.6% vs. 73.0%). Single or split dose PMC preparations were comparable. A PMC based solution was generally better tolerated than PEG regardless of the regimen used (p < 0.001). Nausea was reported mostly after the 4L PEG (32.8%, p < 0.001), incontinence after a split PMC dose (34.4%, p = 0.002), and bloating after the 4L PEG (38.0%, p < 0.001). There was no significant difference in the prevalence of vomiting.Conclusion: Colonic preparation with PMC yields similar results as a split PEG dose, regardless of whether PMC is administered in single or separate doses. PMC is better tolerated than any PEG-based preparation. A single 4L PEG the day before the colonoscopy is less appropriate for bowel cleansing.

Aquanet Bowel Cleansing Device Versus Oral Sodium Picosulfate for Pre-Endoscopy Bowel Preparation: Propensity Score Analysis for Interventional Effectiveness Evaluation

“…The use of cleansing methods such as enemas and laxatives is important in increasing the sensitivity of the colonoscopy procedures. Most enemas have their causal mechanisms related to rectal distension and mucosa irritation [ 10 , 11 ]. Commonly used bowel preparation enema and laxative methods include polyethylene glycol (PEG) and sodium picosulfate solution (Picoprep), respectively [ 12 , 13 ].…”

Monitoring of allograft vasculopathy by intravascular ultrasound one month and one year after heart transplantation: A single center study

“…In particular, steroid therapy may have contributed to the fact that two patients experienced pyrosis-like symptoms and dyspepsia, leading to the need of gastroscopy, which was, however, negative. During gastroscopy, as well as all other endoscopy examination, it is necessary to observe the principles of safe digestive endoscopy [16][17][18][19] . Besides CAV diagnostics, IVUS is used for verifying new therapy strategies in patients after HTx.…”

Preparation of the intestine for colonoscopy of women with reproductive system pathology

“…В исследовании, проведенном V. Kojecky с соавт. [6], натрия пикосульфат и цитрат магния сравнивались с раздельным режимом полиэтиленгликоля (3+1) и полнообъемным (4 л) режимом полиэтиленгликоля вечером накануне исследования. Удовлетворительное качество подготовки кишки (по шкале Арончик 1 и 2) наблюдалось значительно чаще при применении раздельных доз препаратов с преимуществом по качеству подготовки у полиэтиленгликоля: ■ 3 литра приготовленного раствора полиэтиленгликоля -первая доза двухэтапной схемы подготовки + 1 литр приготовленного раствора полиэтиленгликолявторая доза двухэтапной схемы подготовки, 87,3%, ■ 150 мл приготовленного раствора натрия пикосульфата и цитрата магния и 2 л разрешенной жидкостипервая доза двухэтапной схемы подготовки + 150 мл приготовленного раствора натрия пикосульфата и цитрата магния и 2 л разрешенной жидкости -вторая доза двухэтапной схемы подготовки, 81,6%, ■ 4 литра приготовленного раствора полиэтиленгликоляодноэтапная схема подготовки, 73% (р = 0,024).…”