A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients

Fujimoto, Yoshifumi; Ochi, Hidenori; Maekawa, Toshiro; Abe, Hiromi; Hayes, C. Nelson; Kumada, Hiromitsu; Nakamura, Yusuke; Chayama, Kazuaki

doi:10.1016/j.jhep.2010.07.021

Cited by 19 publications

(17 citation statements)

References 36 publications

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“…Rho GTPases are found activated in several tumors, which is mainly based on overexpression of the GTPases or their activators, the guanine nucleotide exchange factors (33). Several reports show that Rho GTPases mediate STAT activation or inhibition (3,4,7,34,35). These studies show that Rho proteins are involved in tumor progression due to stimulation of STAT-dependent transcription.…”

Section: Discussionmentioning

confidence: 99%

Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling

Reipschläger

Kubatzky

Taromi

et al. 2012

Journal of Biological Chemistry

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Background: Rho GTPases are involved in STAT-dependent transcription. However, the connecting signaling pathways are unknown. Results: Activated RhoA induces STAT3 phosphorylation via ROCK, JNK, CCL1 synthesis, and secretion. Conclusion: Auto/paracrine cytokine signaling is a link between RhoA and STAT3. Significance: The knowledge about the connection between RhoA and STAT signaling is crucial for understanding several diseases, especially cancer.

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Section: Discussionmentioning

confidence: 99%

Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling

Reipschläger

Kubatzky

Taromi

et al. 2012

Journal of Biological Chemistry

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“…A tag SNP (rs2278034) in intron 11 of ACK1 was associated with IFN therapy outcome in patients infected with HCV. SNP (rs8099917) in IL-28 influences its expression in patients, which interferes with drug therapy against HCV 51-52. On the other hand, IFIT family genes are important ISGs, which play important roles in resisting HCV infection.…”

Section: Genetic Variants Of Ifit Family Genesmentioning

confidence: 99%

Interferon Induced IFIT Family Genes in Host Antiviral Defense

Zhou

Michal²,

Zhang³

et al. 2013

Int. J. Biol. Sci.

194

184

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Secretion of interferons (IFNs) from virus-infected cells is a hallmark of host antiviral immunity and in fact, IFNs exert their antiviral activities through the induction of antiviral proteins. The IFN-induced protein with tetratricopeptide repeats (IFITs) family is among hundreds of IFN-stimulated genes. This family contains a cluster of duplicated loci. Most mammals have IFIT1, IFIT2, IFIT3 and IFIT5; however, bird, marsupial, frog and fish have only IFIT5. Regardless of species, IFIT5 is always adjacent to SLC16A12. IFIT family genes are predominantly induced by type I and type III interferons and are regulated by the pattern recognition and the JAK-STAT signaling pathway. IFIT family proteins are involved in many processes in response to viral infection. However, some viruses can escape the antiviral functions of the IFIT family by suppressing IFIT family genes expression or methylation of 5' cap of viral molecules. In addition, the variants of IFIT family genes could significantly influence the outcome of hepatitis C virus (HCV) therapy. We believe that our current review provides a comprehensive picture for the community to understand the structure and function of IFIT family genes in response to pathogens in human, as well as in animals.

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“…After interferon monotherapy homozygous carriers of the TNK2 rs2278034A>G variant were more likely to achieve SVR (OR 7.06). However, this was not seen in IFN/RBV combination therapy [119].…”

Section: Downstream Interferon Signalingmentioning

confidence: 87%

“…Its activation leads to ISG expression, presumably via STAT1 phosphorylation and inhibition of HCV replication in the HCV replicon system [119]. After interferon monotherapy homozygous carriers of the TNK2 rs2278034A>G variant were more likely to achieve SVR (OR 7.06).…”

Section: Downstream Interferon Signalingmentioning

confidence: 99%