A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer

Matsumura, Shunji; Oue, Naohide; Nakayama, Hirofumi; Kitadai, Yasuhiko; Yoshida, Kazuhiro; Yamaguchi, Yoshiyuki; Imai, Kazue; Nakachi, Kei; Matsusaki, Keisuke; Chayama, Kazuaki; Yasui, Wataru

doi:10.1007/s00432-004-0621-4

Cited by 109 publications

(84 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We did not find differences in genotype distribution for MMP-9 À1562C4T between gastric cancer patients and controls either, which is in agreement with the study of Matsumura et al (2005) in Japanese patients. However, that study showed significant associations of the CT/TT genotype with depth of invasion, lymphatic invasion and TNM classification.…”

Section: Discussionsupporting

confidence: 91%

“…Matrix metalloproteinase-7 À181A4G was the only polymorphism differently distributed among gastric carcinoma patients compared with control subjects: AA 43.0%, AG 46.8%, and GG 10.1% in patients vs AA 27.2%, AG 62.7% and GG 10.1% in controls (Po0.04; Table 2). Comparison of the genotype distribution of our Caucasian control subjects with those published on other mainly Asiatic control groups (Wollmer et al, 2002;Ghilardi et al, 2003;Krex et al, 2003;Miao et al, 2003;Wang et al, 2004;Zhou et al, 2004;Matsumura et al, 2005;Zhang et al, 2005) showed significant differences for MMP-2 À1306C4T , MMP-7 À181A4G , TIMP-1 372C4T and TIMP-2 À418G4C (Table 3). All the SNPs were evaluated for association with the clinicopathological parameters.…”

Section: Resultsmentioning

confidence: 49%

“…Particularly, genotypes with the MMP-7 À181G allele (A/G þ G/G) showed a significantly increased susceptibility for gastric cardiac carcinoma with an odds ratio of 1.96 (Zhang et al, 2005). Finally, a significant association in Japanese gastric cancer patients was found between an SNP in the promoter of the MMP-9 gene (À1562C4T) and the degree of tumour invasion, clinical stage and lymphatic invasion (Matsumura et al, 2005). However, as indicated above, these studies on MMP-SNPs in gastric carcinoma patients describe ethnic Chinese and Japanese populations with a known high incidence of gastric cancer.…”

mentioning

confidence: 89%

See 2 more Smart Citations

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer

et al. 2006

View full text Add to dashboard Cite

Gastric cancers express enhanced levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Single-nucleotide polymorphisms (SNPs) in MMP and TIMP genes may be associated with disease susceptibility and might also affect their antigen expression. We studied the genotype distribution and allele frequencies of SNPs of MMP-2, -7, -8 and -9 and TIMP-1 and -2 in gastric cancer patients in relation to tumour progression, patient survival and tissue antigen expression. The genotype distribution and allele frequencies were similar in gastric cancer patients and controls, except for MMP-7 À181A4G . In addition, the genotype distribution of MMP-7 À181A4G was associated with Helicobacter pylori status (w 2 7.8, P ¼ 0.005) and tumour-related survival of the patients. Single-nucleotide polymorphism TIMP-2 303C4T correlated significantly with the WHO classification (w 2 5.9, P ¼ 0.03) and also strongly with tumour-related survival (log rank 11.74, P ¼ 0.0006). Single-nucleotide polymorphisms of MMP-2, -8, -9 and TIMP-1 were not associated with tumour-related survival. Only the gene promoter MMP-2 À1306C4T polymorphism correlated significantly with the protein level within the tumours. First-order dendrogram cluster analysis combined with Cox analysis identified the MMP-7 À181A4G and TIMP-2 303C4T polymorphism combination to have a major impact on patients survival outcome. We conclude that MMP-related SNPs, especially MMP-7 À181A4G and TIMP-2 303C4T , may be helpful in identifying gastric cancer patients with a poor clinical outcome.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 49%

mentioning

confidence: 89%

See 1 more Smart Citation

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Positive association of MMP-9 -1562 C/T polymorphism and colon cancer risk has been reported by Woo et al [61] in Korean population. Other studies reported a higher incident of lymph node metastasis in gastric and colon cancer patients having CC genotype at -1562 bp [64,65] . Association of SNPs in MMP-3 promoter and gastrointestinal cancer has been investigated in MMP-3 -1171 6A/5A site, since transcription repressor bind strongly with 6A allele leading to reduced gene expression.…”

Section: Mmps Polymorphism In Tumor Formationmentioning

confidence: 89%

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Verma

Kesh

Ganguly

et al. 2014

WJBC

View full text Add to dashboard Cite

teinase (TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK (reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2, -9 and -14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species (ROS) through mitochondrial dysfunction leading to altered protease/ anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. AbstractThe process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases (MMPs). Degradation of extracellular matrix (ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-

show abstract

“…The selected SNPs were also previously analyzed in other cancers, such as lung, stomach, ovarian and bladder cancer. The results of these studies point to a positive correlation between MMPs polymorphism and the susceptibility to develop cancer, tumor invasiveness and further progression of the disease [22,23].…”

mentioning

confidence: 97%

Genetic polymorphism of matrix metalloproteinases in breast cancer

Wieczorek¹,

Reszka²,

Gromadzińska³

et al. 2012

neo

View full text Add to dashboard Cite

The family of human matrix metalloproteinases (MMPs) consists of 24 zinc-and calcium-dependent proteolytic enzymes. MMPs are divided into six subgroups, in terms of differences in the substrate specificity with structural domain architecture. These enzymes are involved in many physiological processes, such as skeletal development, wound healing, scar formation, as well as carcinogenesis. MMPs, fulfilling its function of degradation of extracellular matrix components, are involved in one of the stages of angiogenesis enabling the development, growth and spread of the primary tumor. Therefore, the search for the common polymorphic variants of MMPs, new genetic markers as prognostic factors in breast cancer progress seems to be understandable.The minireview presents the results of 19 case-control or prospective studies concerning the association of SNPs of genes encoding nine MMPs: MMP-1, -2, -3, -7, -8, -9, -12, -13, -21 with the breast cancer risk, progression and survival. Key words: matrix metalloproteinases, genetic polymorphism, breast cancerBreast cancer, one of the leading civilization diseases, has for a number of years already focused attention of clinicians and researchers. It is the most commonly diagnosed cancer in women and is the major cause of death among female cancer patients. GLOBCAN estimates that, among the 12.7 million cancer cases worldwide in 2008, 2.9 million were women with breast cancer, and a million died of this cancer [1]. It is estimated that approximately 10% of the incidence of breast cancer is genetically-related and in most of the cases results from mutations in the genes BRCA1, BRCA2, p53, ATM. Attention should also be paid to a number of environmental factors related to diet and occupational exposure, including tobacco smoking, alcohol intake, obesity, shift work at night. Factors considered in the etiology of breast cancer include also endogenous hormonal factors, such as age of occurrence of menarche, menopause, number of births, and exogenous hormonal factors such as use of hormonal contraceptives or hormonal replacement [2,3]. Currently, a description of cancer cases includes clinical stage and Tumor Nodus Metastases (TNM) clinical classification, hormone receptor status and BRCA1, BRCA2 mutations. All these indicators are still not sufficient to predict the course of the cancer and, therefore, it is important to search for new markers that will enable the patient's prognosis and new predictive markers of cancer risk. As the majority of breast cancer deaths are caused by the invasion of cancer to other, sometimes distant organs, it is believed that it is appropriate to study the role of the enzyme gene polymorphisms that affect the process of angiogenesis largely responsible for the development, growth and metastatic capacity of the primary tumor. Key enzymes involved in these processes include the matrix metalloproteinases (MMPs) participating in an important stage of angiogenesis, namely the degradation of extracellular matrix (ECM) components.Matrix metalloproteinases. MM...

show abstract

A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer

Abstract: Our results indicate that the T allele in the MMP-9 promoter is associated with the invasive phenotype of gastric cancer.

Cited by 109 publications

References 26 publications

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Genetic polymorphism of matrix metalloproteinases in breast cancer

Contact Info

Product

Resources

About