A single nucleotide polymorphism in the rabbit growth hormone (GH1) gene is associated with market weight in a commercial rabbit population

Fontanesi, Luca; Dall’Olio, Stefania; Spaccapaniccia, E.; Scotti, Emilio; Fornasini, Daniela; Frabetti, Andrea; Russo, Vincenzo

doi:10.1016/j.livsci.2012.04.006

Cited by 23 publications

(52 citation statements)

References 30 publications

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“…Additive genetic effect (a) and dominance effect (d) were calculated as described by Fontanesi et al (2012). In brief, the additive genetic effect for the PGAM2 genotypes was estimated as half of the difference between values of the two homozygous groups.…”

Section: Animals Growth Traits and Carcass Traitsmentioning

confidence: 99%

Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits

Wu¹,

Chen²,

Jia³

et al. 2015

Czech J. Anim. Sci.

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Phosphoglycerate mutase (PGAM2) catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate and releases energy during glycolysis in muscle tissues. PGAM2 has been considered as a candidate gene to influence growth, development, and carcass traits in livestock. The aim of this study was to investigate the association between polymorphisms of PGAM2 and growth traits in rabbits. Three single nucleotide polymorphisms (SNPs) were identified by direct sequencing in 20 random individuals from three breeds, including c.-10C>T, c.195C>T, and c.414+17C>T. The c.195C>T was genotyped by PCR-RFLP in a total of 222 rabbits of three breeds (Tianfu black, 53 animals; Ira, 91 animals; Champagne, 78 animals). The average allele frequency among the breeds was 0.52 for allele T and 0.48 for C. The heterozygosity and effective number of alleles were 0.4992 and 1.996, respectively. The association results revealed the CT genotype of c.195C>T was associated significantly (P < 0.05) with greater body weight at 84 days of age (BW84) and with average daily weight gain (ADG). However, association of the genotypes with other production traits was not observed. The results of this study suggested PGAM2 is one of the candidate genes affecting BW84 and ADG in the rabbit.

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Section: Animals Growth Traits and Carcass Traitsmentioning

confidence: 99%

Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits

Wu¹,

Chen²,

Jia³

et al. 2015

Czech J. Anim. Sci.

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“…Amplification of PCR was carried out by using specific primer (Fontanesi et al, 2012) for parts of the 5'-flanking region and 5'untranslated region, exon 1 and with method of two step gradient cycle PCR (Lopez & Prezioso, 2001;Xiong, 2004). Primers used were for forward 5'-GTATAGTGGGATGGGGTTGG -3 'and reverse 5'-TTACGCTCCCATTCAGAAGC -3' (Gen Bank access number Z28137).…”

Section: Polymerase Chain Reaction (Pcr)mentioning

confidence: 99%

“…The amplification fragment of the GH gene was performed by Fontanesi et al (2012) with an annealing temperature of 58 o C, but in this research has different temperature to get amplicon. The optimal annealing annealing temperature in this research was 68 o C on 5 cycle and 60 o C on 15 cycle.…”

Section: Gh Gene Amplificationmentioning

confidence: 99%

“…Genotyping the GH|Bsh1236I gene, showed for the resulted one fragment of 231 identified for the TT genotype; one fragment of 169 bp for the CC genotype; and two fragments of 231 and 169 bp for the CT genotype. Identification of the GH gene polymorphism in rabbit has been done by PCR-RFLP using Bsh1236I restriction enzyme by Fontanesi et al (2012) who reported the presence of two types of alleles, namely C and T alleles with three kinds of genotypes, namely CC, TT, and CT genotypes.…”

Section: Gh|bsh1236i Gene Polymorphismmentioning

confidence: 99%

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The Variability of Growth Hormone Gene Associated with Ultrasound Imaging of Longissimus dorsi Muscle and Perirenal Fat in Rabbits

Amalianingsih¹,

Brahmantiyo²,

Jakaria³

2014

Med Pet

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“…a ¼ 1/2(BB À AA) and the dominance effect (d) as AB À1/2(AA þ BB). The ratio jd/aj was considered to indicate gene effects (Stuber et al 1987): jd/ aj < 0.2, additive; 0.2 < jd/aj < 0.8, partial dominance; 0.8 < jd/a j< 1.2, dominance; jd/aj > 1.2, overdominance (Fontanesi et al 2012). In order to isolate the interaction of fixed effects, we evaluate the interactions between the fixed factors considered (farm-seasonality, farm-parity, parity-seasonality).…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the STAT5A, MTNR1A and TNFα genes and their effect on dairy production in Bubalus bubalis

Coizet

Frattini

Nicoloso

et al. 2017

Italian Journal of Animal Science

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The water buffalo is a fundamental resource, especially in developing countries, however, differently from other species, its genetic potential is still poorly investigated. In this work, we performed a candidate gene association study for milk composition in 491 female buffaloes. Animals were from four farms located in Southern Italy, where the Out-of-Breeding-SeasonMating technique is usually performed. We analysed three genes: (1) the signal transducer and activator of transcription 5A (STAT5A), (2) the tumour necrosis factor alpha (TNFa) and (3) the melatonin receptor 1A (MTNR1A). We confirmed the mutation at the MTNR1A gene and we found five novel single nucleotide polymorphisms (SNPs): one in the TNFa and four in the STAT5A. No associations were found for the SNPs in the MTNR1A and TNFa genes, while we identified a marked association with milk protein % for a C > T substitution at the STAT5A gene. At this locus, the TT buffaloes showed significantly higher protein percentage in milk. Conversely, this genotype class was the less frequent in the population. Moreover, an A > G substitution at the STAT5A showed an influence on reproductive seasonality, with the advantageous allele most frequent in the population, suggesting a possible effect of selection for this trait. The C > T substitution on STAT5A detected in present study could be used in marker assisted selection of Mediterranean Italian buffalo, and should be monitored to understand the reasons behind the low frequency of the favourable genotype at this locus and to stop this unfavourable trend in the population. ARTICLE HISTORY

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A single nucleotide polymorphism in the rabbit growth hormone (GH1) gene is associated with market weight in a commercial rabbit population

Cited by 23 publications

References 30 publications

Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits

Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits

The Variability of Growth Hormone Gene Associated with Ultrasound Imaging of Longissimus dorsi Muscle and Perirenal Fat in Rabbits

Polymorphism of the STAT5A, MTNR1A and TNFα genes and their effect on dairy production in Bubalus bubalis

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