A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

Jiang, Chao Qiang; Liu, Bin; Cheung, Bernard M Y; Lam, Tai Hing; Lin, Jie; Jin, Ya Li; Xiao, Yue; Tam, Sidney; Wong, Ka Sing; Tomlinson, Brian; Lam, Karen S.L.; Thomas, G. Neil

doi:10.1038/ejhg.2010.93

Cited by 27 publications

(27 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A higher incidence of a T/C SNP (SNP3 or c.553G>T) in the 5′ region of the ApoA5 gene was correlated to increased TG levels in Japanese adult population (n=481 male and n=412 female) and children (n=552) compared to Caucasian population [30, 31]. A similar association was seen between ApoA5 locus −1131T>C and high TG and low HDLc in all Caucasian population from Cooperative Health Research in the region of Augsburg (KORA) and the Salzburg Atherosclerosis Prevention Program in Subjects in High Individual Risk (SAPHIR) study (n=1,354) [32] and patient cohorts from the Hong Kong cardiovascular risk factor prevalence study and the Guangzhou Biobank Cohort Study [33]. …”

Section: Apoa5 In Cardiometabolic Diseasesmentioning

confidence: 80%

The paradox of ApoA5 modulation of triglycerides: Evidence from clinical and basic research

Garelnabi

Lor

Jin

et al. 2013

Clinical Biochemistry

View full text Add to dashboard Cite

Apolipoprotein A5 (ApoA5) is a key regulator of plasma triglycerides (TG), although its plasma concentration is very low compared to other known apoproteins. Over the years, researchers have attempted to elucidate the molecular mechanisms by which ApoA5 regulates plasma TG in vivo. Though still under debate, two theories broadly describe how ApoA5 modulates TG levels: (i) ApoA5 enhances the catabolism of TG-rich lipoproteins and (ii) it inhibits the rate of production of very low-density lipoprotein (VLDL), the major carrier of TGs. This review will summarize the basic and clinical studies that have attempted to describe the importance of ApoA5 in TG metabolism. Population studies conducted in various countries have demonstrated an association between single nucleotide polymorphisms (SNPs) in ApoA5 and the increased risk to cardiovascular disease and metabolic syndrome (including diabetes and obesity). ApoA5 is also highly expressed during liver regeneration and is an acute phase protein associated with HDL which was independent of its effects on TG metabolism. Conclusion Despite considerable evidences available from clinical and basic research studies, on the role of ApoA5 in TG metabolism and its indirect link to metabolic diseases, additional investigations are needed to understand the paradoxical role of this important apoprotein shown modulated by diet and from it polymorphism variants.

show abstract

Section: Apoa5 In Cardiometabolic Diseasesmentioning

confidence: 80%

The paradox of ApoA5 modulation of triglycerides: Evidence from clinical and basic research

Garelnabi

Lor

Jin

et al. 2013

Clinical Biochemistry

View full text Add to dashboard Cite

show abstract

“…The reported effect size on triglyceride concentration of the less common "C" allele varies from about 30% in Caucasians [15] to 36% in Chinese [16] and 60% in Turks [17]. …”

Section: Discussionmentioning

confidence: 99%

Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood

et al. 2011

View full text Add to dashboard Cite

BackgroundTriglycerides is an independent risk factor for coronary artery disease (CAD) and is especially important in Indians because of high prevalence of hypertriglyceridemia in this population. Both genetic and environmental factors determine triglyceride levels. In a birth cohort from India, hypertriglyceridemia was found in 41% of men and 11% of women. Subjects who had high triglycerides had more rapid body mass index (BMI) or weight gain than rest of the cohort throughout infancy, childhood and adolescence. We analysed polymorphisms in APOA5, hepatic lipase and PPARγ genes and investigated their association with birth weight and serial changes in BMI.ResultsPolymorphisms in APOA5 (-1131T > C, S19W), PPARγ (Pro12Ala) and hepatic lipase (-514C > T) were studied by polymerase chain reaction (PCR) followed by restriction digestion in 1492 subjects from the New Delhi Birth Cohort (NDBC). We assessed whether these polymorphisms influence lipid and other variables and serial changes in BMI, both individually and together.The risk allele of APOA5 (-1131C) resulted in 23.6 mg/dl higher triglycerides as compared to normal allele (P < 0.001). Risk allele of HL (-514T) was associated with significantly higher HDL2 levels (P = 0.002). Except for the marginal association of PPARγ Pro12Ala variation with a lower conditional weight at 6 months, (P = 0.020) and APOA5 S19W with a higher conditional BMI at 11 yrs of age (P = 0.030), none of the other associations between the gene polymorphisms and serial changes in body mass index from birth to young adulthood were significant.ConclusionThe promoter polymorphism in APOA5 was associated with raised serum triglycerides and that of HL with raised HDL2 levels. None of the polymorphisms had any significant relationship with birth weight or serial changes in anthropometry from birth to adulthood in this cohort.

show abstract

“…Plasma ADM was measured in 476 subjects randomly selected from the sub-cohort of 1375 subjects in the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (24). There was no significant difference in age, sex, and body mass index (BMI) between the subjects with and without measurement of plasma ADM (all PO0.05).…”

Section: Subjectsmentioning

confidence: 97%

“…The study protocol was approved by the Ethics Committee of the University of Hong Kong. Details on the study protocols and the measurement methods of clinical parameters such as BMI, blood pressure, fasting glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and adiponectin have been described previously (24)(25)(26)(27)(28)(29). Regular drinking was defined as alcohol drinking at least once a week.…”

Section: Subjectsmentioning

confidence: 99%

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Cheung

Ong²,

Tso³

et al. 2011

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Objective: Adrenomedullin (ADM) plays an important role in inflammation and is a marker of future cardiovascular events. We studied common single nucleotide polymorphisms (SNPs) in the gene encoding ADM and their relationship with the plasma levels of ADM and other inflammatory markers. Design and methods: Plasma ADM, interleukin 6 (IL6), fibrinogen, and C-reactive protein (CRP) were measured in 476 subjects from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study-2. Four tag SNPs in ADM were genotyped. Results: Plasma ADM level increased with decreasing plasma IL6 level (bZK0.116, PZ0.014). Plasma ADM level was not related to plasma levels of CRP and fibrinogen, and other clinical characteristics, except age (PZ0.049). The four SNPs, rs3814700, rs11042725, rs34354539, and rs4910118, had minor allele frequencies of 31.1, 28.7, 33.8, and 23.4% respectively. Carriers of the minor allele of rs4910118 had a mean plasma ADM level that was 10.5% (95% confidential interval: 2.5-17.8%) lower than the non-carriers (bZK0.115, PZ0.011). Haplotype analysis revealed a similar significant association with plasma ADM (PZ0.040). In multivariate analysis, the presence of the minor allele of rs4910118, but not plasma IL6, was independently associated with plasma ADM (PZ0.010). Conclusion: Plasma ADM correlates with plasma IL6 level, consistent with its role in inflammation. It is related to an SNP common in Chinese, independent of other covariates. ADM genotype should be included in future studies of cardiovascular risk prediction.

show abstract

A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

Cited by 27 publications

References 44 publications

The paradox of ApoA5 modulation of triglycerides: Evidence from clinical and basic research

The paradox of ApoA5 modulation of triglycerides: Evidence from clinical and basic research

Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood

Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene

Contact Info

Product

Resources

About