A single nucleotide polymorphism in the parathyroid hormone gene and effects on eggshell quality in chickens

Jiang, Runshen; Xie, Zhongwen; Chen, X. Y.; Zhao, Geng

doi:10.3382/ps.2010-00888

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…Also, Preda et al 2013found that higher production of eggs induces an increase in the plasma concentration of calcium. The obtained results of increasing plasma Ca , Ph and PTH levels related to the increase of Ca and Ph levels in eggshell (Table 3) and eggshell quality (Table 2) and OPN concentration (Table 1) are in harmony with those previously mentioned by Jiang et al (2010) and Preda et al (2013) who found that the increase of PTH concentration was parallel with the plasma calcium level and PTH controls Ca and Ph level of blood and maintains the Ca homeostasis by regulating Ca liberation from the bone. Furthermore, Noda and Rodan (1989) and Lavelin et al (2000) revealed that calcitrophic substance such as PTH hormone had regulation effect on OPN gene expression.…”

Section: Statistical Analysessupporting

confidence: 85%

“…Furthermore, Noda and Rodan (1989) and Lavelin et al (2000) revealed that calcitrophic substance such as PTH hormone had regulation effect on OPN gene expression. Moreover, Jiang et al (2010) cleared that better eggshell quality and breaking strength could be due to the higher blood Ca, OPN and PTH. Bone strength: It is clear from Figure 3 that the tibia bone of embryos at day 15 and hatched chicks are stronger(p≤0.05) for M chicken strain than those for G one.…”

Section: Statistical Analysesmentioning

confidence: 99%

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Effect of Eggshell Osteopontin Protein on Skeletal Embryonic Development and Hatching Traits of Developed Chicken Strains

2017

EPSJ

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The present study was designed to study the change of shell quality, shell strength, hatching output, calcium (ca) and phosphorus (ph) concentrations in tibia bone for embryos and hatched chicks, bone strength and some related physiological parameters as affected by either chicken strain (Mandarah, M and Gimmizah, G) or osteopontin (OPN) protein in eggshell. Results indicated that M strain surpassed (p≤0.05) G one for OPN concentration (ng/ µL) in eggshell of fresh eggs, eggshell at hatch, tibia for hatched chicks besides in hatched chick's blood. Egg quality including eggshell weight %,shell index, shell strength (Newton), eggshell and eggshell membranes thickness (mm) were significantly increased for M strain compared with those for G one, whereas egg abnormalities % and egg weights were significantly (p≤0.05) increased for G chickens. Moreover, egg weight loss % during incubation, embryonic mortality %, hatch time (h) and hatch window (h) were significantly diminished for eggs produced from M chickens compared to those for G one besides, M strain had the higher percentage of hatchability of fertile eggs (p≤0.05). Mandarah chickens represented significant increase of ca and ph concentrations compared with G ones in fresh eggs and eggshell for embryos at days 9 and 15. Mandarah chicks surpassed (p≤0.05) G ones with respect to plasma ca, ph and parathyroid hormone. Also, tibia bones for embryos at day 15 and hatched chicks were stronger (p≤0.05) for M strain than those for G one. The important role of the genes due to chicken strain besides OPN protein in eggshell and embryonic bone could open promising tool for understanding the quality of eggshell and its applications for breeding programs.

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Section: Statistical Analysessupporting

confidence: 85%

Section: Statistical Analysesmentioning

confidence: 99%

Effect of Eggshell Osteopontin Protein on Skeletal Embryonic Development and Hatching Traits of Developed Chicken Strains

2017

EPSJ

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“…The metabolism of calcium is regulated by several main hormones, such as PTH, calcitonin, stanniocalcin, estrogens, and thyroid hormone . Therefore, these hormones may influence avian eggshell strength by regulation of calcium metabolism, and the associations between PTH gene and eggshell quality have been discovered . Our present study suggests TTR and RBP4 should be paid more attention for their association with eggshell quality.…”

Section: Resultsmentioning

confidence: 59%

Differential label‐free quantitative proteomic analysis of avian eggshell matrix and uterine fluid proteins associated with eggshell mechanical property

Sun

Yang

2013

Proteomics

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Eggshell strength is a crucial economic trait for table egg production. During the process of eggshell formation, uncalcified eggs are bathed in uterine fluid that plays regulatory roles in eggshell calcification. In this study, a label-free MS-based protein quantification technology was used to detect differences in protein abundance between eggshell matrix from strong and weak eggs (shell matrix protein from strong eggshells and shell matrix protein from weak eggshells) and between the corresponding uterine fluids bathing strong and weak eggs (uterine fluid bathing strong eggs and uterine fluid bathing weak eggs) in a chicken population. Here, we reported the first global proteomic analysis of uterine fluid. A total of 577 and 466 proteins were identified in uterine fluid and eggshell matrix, respectively. Of 447 identified proteins in uterine fluid bathing strong eggs, up to 357 (80%) proteins were in common with proteins in uterine fluid bathing weak eggs. Similarly, up to 83% (328/396) of the proteins in shell matrix protein from strong eggshells were in common with the proteins in shell matrix protein from weak eggshells. The large amount of common proteins indicated that the difference in protein abundance should play essential roles in influencing eggshell strength. Ultimately, 15 proteins mainly relating to eggshell matrix specific proteins, calcium binding and transportation, protein folding and sorting, bone development or diseases, and thyroid hormone activity were considered to have closer association with the formation of strong eggshell.

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“…This SNP caused a missense mutation resulting in a change from histidine to arginine. Importantly, these three SNP (rs313064671, rs317191671, and rs316353058) of the OC-116 gene were in the conserved domain (http://asia.ensembl.org/Gallus_gallus/Transcript/ Domains), suggesting that these SNPs may alter the structure of the conserved domain and affect protein function during the initial phase of shell mineralization (Jiang et al, 2010).…”

Section: Ovocleidin-116mentioning

confidence: 99%

Gene Polymorphisms are Associated with Eggshell Ultrastructure Organization in Hens

Wang

Liao²,

Zhang

et al. 2017

Rev. Bras. Cienc. Avic.

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Background: Eggshell ultrastructure organization, including effective layer thickness, mammillary layer thickness, and average size of mammillary cones, is important for breeding and significantly influences eggshell mechanical properties. Several matrix proteins were known to be important in eggshell formation. However, the proteins and variations that determine eggshell ultrastructure organization are not known.Results: In this study, 17 single-nucleotide polymorphisms of three major genes in a hen population using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. Five single-nucleotide polymorphisms with a very low minor allele frequency (< 1%) were excluded from further analysis. The remaining 12 single-nucleotide polymorphisms in Hardy-Weinberg equilibrium were used for analysis of associations with eggshell ultrastructure organization. Associations were found for (i) ovocleidin-116 with effective layer thickness (EFF), mammillary layer thickness (MAM), and average size of mammillary cones (SMAM); (ii) ovalbumin with eggshell thickness (ESH), effective layer thickness, and density of the mammillary cone (DMAM); and (iii) calmodulin1 with density of the mammillary cone.Conclusions: The single-nucleotide polymorphisms identified in the present study may be used as potential markers to improve eggshell quality.

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A single nucleotide polymorphism in the parathyroid hormone gene and effects on eggshell quality in chickens

Cited by 12 publications

References 23 publications

Effect of Eggshell Osteopontin Protein on Skeletal Embryonic Development and Hatching Traits of Developed Chicken Strains

Effect of Eggshell Osteopontin Protein on Skeletal Embryonic Development and Hatching Traits of Developed Chicken Strains

Differential label‐free quantitative proteomic analysis of avian eggshell matrix and uterine fluid proteins associated with eggshell mechanical property

Gene Polymorphisms are Associated with Eggshell Ultrastructure Organization in Hens

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