A single LC–tandem mass spectrometry method for the simultaneous determination of four H2 antagonists in human plasma

Sun, Xinghuai; Tian, Ye; Zhang, Zunjian; Chen, Yun

doi:10.1016/j.jchromb.2009.10.003

Cited by 21 publications

(12 citation statements)

References 29 publications

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“…Quantitative analysis was carried out by MRM at m/z 251.2  108.2 15 for lacosamide and at m/z 315.1  176.1 16 for ranitidine HCl. In vitro Tablet Dissolution Study.…”

Section: Methodsmentioning

confidence: 99%

Preparation of Lacosamide Sustained-release Tablets and Their Pharmacokinetics in Beagles and Mini-pigs

Ahn¹,

Kim²,

Nam³

et al. 2014

Bulletin of the Korean Chemical Society

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The aim of the present study was to improve dosing of lacosamide, a functionalized amino acid used as an antiepileptic agent, from twice daily to once daily for the convenience of patients. A sustained-release lacosamide tablet was developed and dissolution testing was employed to determine in vitro release behavior using water or buffer solutions at pH 1.2, 4.0, or 6.8. Lacosamide was released for 12 h from the sustainedrelease (SR) tablet, as compared to complete release within 1 h from an immediate-release Vimpat ® tablet. Each formulation (100 mg) was orally administered to six beagle dogs and six mini-pigs under fasted conditions, and pharmacokinetic parameters such as the area under the concentration time curve (AUC t ), the maximum plasma concentration (C max ), and the time at which this occurred (T max ) were calculated. These results showed similar values for AUC t , C max , and T max following oral administration of immediate-release (Vimpat ® ) and SR lacosamide tablets.

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“…Quantitative analysis was carried out by MRM at m/z 251.2  108.2 15 for lacosamide and at m/z 315.1  176.1 16 for ranitidine HCl. In vitro Tablet Dissolution Study.…”

Section: Methodsmentioning

confidence: 99%

Preparation of Lacosamide Sustained-release Tablets and Their Pharmacokinetics in Beagles and Mini-pigs

Ahn¹,

Kim²,

Nam³

et al. 2014

Bulletin of the Korean Chemical Society

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“…7 The method is highly selective and various co expedients such as dextrose, lactose, fructose and boric acid are tolerable at high concentrations and x n cimetidine can be determined quantitatively in the presence of these compounds. The method was validated for the quantitative determination of cimetidine in some pharmaceutical preparations.…”

Section: -4mentioning

confidence: 99%

“…These include spectrophotometric, 2 ion-selective electrode, 1 solid phase extraction, 5 high performance liquid chromatography (HPLC) 6 and LC-tandem mass spectrometry. 7 However some of the quantitative pharmaceutical determination methods such as HPLC suffer from large solvent consumption.…”

Section: Introductionmentioning

confidence: 99%

Extraction-Spectrophotometric Determination of Cimetidine in Pharmaceutical Samples as an Ion Pair with Bromothymol Blue

Zargar¹,

Pourreza²,

Shahrouz³

2011

Journal of the Korean Chemical Society

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주제어: 추출-분광광도법, 시메티딘, 브로모티몰 블루ABSTRACT. A highly sensitive and selective extraction-spectrophotometric method has been developed for determination of trace amounts of cimetidine. This method is based on the extraction of cimetidine as an ion pair with bromothymol blue (BTB) into chloroform and measuring its absorbance at 417 nm. The effect of different variables such as pH, concentration of BTB, volume of chloroform and shaking time was investigated. The effect of interfering ions on the extraction was also studied. The calibration curve was linear in the range of 0.25-8 µg mL -1 with correlation coefficient of 0.9997. The detection limit based on 3Sb was 0.14 µg mL -1 and relative standard deviation for 10 replicated measurements of 1.0 and 4.0 µg mL -1 of cimetidine was 3.2 and 1.49%, respectively. The proposed method was applied to the determination of cimetidine in pharmaceutical samples with good recoveries.

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“…A literature survey retrieved a large number of references reporting analytical methods for the determination of these compounds. Mainly separation techniques such as Gas Chromatography (GC) [2], High Performance Thin Layer Chromatography (HPTLC) [3][4][5][6][7][8][9][10], Capillary Electrophoresis (CE) [11][12][13][14][15][16][17] and High Performance Liquid Chromatography (HPLC) [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] have been used, with the latter being the predominant technique for the determination of these compounds in a variety of matrices, utilizing different methods of sample pretreatment and detection modes. HPLC with ultra-violet (UV) detection, employing reversed phase particle packed columns, is most frequently used for the analysis of these drugs in pharmaceutical preparations and biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Use of a monolithic column for the development and validation of a HPLC method for the determination of famotidine, cimetidine and nizatidine in biological fluids

Κοντού¹,

Zotou²

2017

J Appl Bioanal

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A simple and selective HPLC method, using a monolithic column, was developed for the simultaneous determination of the histamine H 2 -receptor antagonists: famotidine, cimetidine and nizatidine, in the presence of sulfadimethoxine as internal standard. The separation was performed on a Chromolith Performance RP-18 column (100 mm x 4.6 mm i.d.) with an isocratic mobile phase consisting of 0.05 mol/L acetate buffer (adjusted to pH 6.5 with triethylamine)/methanol/ acetonitrile (85:10:5, v/v/v). The wavelength was set at 230 nm. Linearity was obtained for concentrations between 0.2 to 50 μg/mL and limits of detection were in the range 0.07-0.17 μg/mL. Full validation with respect to linearity, selectivity, detection and quantification limits, accuracy, precision and robustness, the latter using the Youden's test, was carried out. The method was successfully applied to the determination of the drugs in human serum and urine following solid phase extraction. Average recoveries between 88.0 to 104.4% and 88.0 to 108.0% in serum and urine samples, respectively, were obtained.

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A single LC–tandem mass spectrometry method for the simultaneous determination of four H2 antagonists in human plasma

Cited by 21 publications

References 29 publications

Preparation of Lacosamide Sustained-release Tablets and Their Pharmacokinetics in Beagles and Mini-pigs

Preparation of Lacosamide Sustained-release Tablets and Their Pharmacokinetics in Beagles and Mini-pigs

Extraction-Spectrophotometric Determination of Cimetidine in Pharmaceutical Samples as an Ion Pair with Bromothymol Blue

Use of a monolithic column for the development and validation of a HPLC method for the determination of famotidine, cimetidine and nizatidine in biological fluids

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