A Single-Institutional Experience of 15 Years of Treating T3 Laryngeal Cancer With Primary Radiotherapy, With or Without Chemotherapy

Primary surgery for advanced‐stage laryngeal cancer: A stage and subsite‐specific survival analysis

“…Mercante et al recently described the excellent oncologic outcomes with their experience of patients with T3 laryngeal tumors treated exclusively with supracricoid partial laryngectomy with 5‐year OS of 87.3%, DSS of 78.2%, and locoregional control of 88.2%. These compare favorably to reported survival outcomes with nonsurgical therapy for these tumors: OS 29%, DFS 60%, and locoregional control 65% . Although the surgical studies focus on a small, select population, their survival rates and local control rates draw attention to a possible survival advantages of surgical intervention.…”

Laryngeal cancer in Finland: A 5‐year follow‐up study of 366 patients

“…Mantsopoulos et al described a 78% 5‐year DSS and a 54% 5‐year OS for 120 patients with glottic T3 tumors who had undergone primary surgical therapy. A 5‐year OS of 49% was reported by Al‐Mamgani et al for 170 patients with T3 laryngeal SCC treated with RT with or without chemotherapy. In their study, the addition of chemotherapy was the only significant predictor of local control.…”

Eliminating radiotherapy to the contralateral retropharyngeal and high level II lymph nodes in head and neck squamous cell carcinoma is safe and improves quality of life

“…[27][28][29] It is noteworthy that QOL scores improved despite the increased use of concurrent chemotherapy in G3 (78% in G3 vs 39% in G1), which is associated with a greater risk of late toxicity and worse QOL. [29][30][31] Given our hypothesis that reducing RT volumes would decrease swallowing morbidity, we thought that the largest impact would occur on the physical and global domains. We observed differences in scores on the global, emotional, and functional domains of greater than 30% of the instrument range.…”