A single-fractal analysis of cellular analyte–receptor binding kinetics utilizing biosensors

Fractal Analysis of Binding and Dissociation of Protein–Analyte Interactions on Biosensor Surfaces

“…The details are not repeated here; except that just the equations are given to permit an easier reading. These equations have been applied to other biosensor systems [4][5][6]. For most applications, a single-or a dual-fractal analysis is often adequate to describe the binding and the dissociation kinetics.…”

A Mathematical Analysis Using Fractals for Binding Interactions of Nuclear Estrogen Receptors Occurring on Biosensor Surfaces

“…The details are not repeated here, except that just the equations are given to permit an easier reading. These equations have been applied to other biosensor systems (14,17). Here we will attempt to apply these equations to (a) the influence of two different ligands on the binding of and dissociation rate coefficients for the interaction between clone 31 protein immobilized on the surface of a CM5 sensor chip and ER␣ in solution (10), (b) influence of different ligands on the binding and dissociation rate coefficients for different analyte-nuclear receptors on a SPR biosensor (11), and (c) binding and dissociation rate coefficients for different concentrations of ER␣ in solution to GST-DRIP immobilized on a sensor chip surface (15).…”

Detection of Biomarkers for Different Diseases on Biosensor Surfaces Part II

“…The details are not repeated here, except that the equations are given to permit an easier reading. These equations have been applied to other biosensor systems (Sadana, 2001;Ramakrishnan and Sadana, 2001;Sadana, 2005). For most applications, a single-or a dual-fractal analysis is often adequate to describe the binding and the dissociation kinetics.…”