A Single Enzyme in Enantiocomplementary Synthesis of β‐Nitroalcohols: Bidirectional Catalysis by Hydroxynitrile Lyase
Sukadev Rana,
Ayon Chatterjee,
Santosh Kumar Padhi
Abstract:A single enzyme, Baliospermum montanum hydroxynitrile lyase (BmHNL), without alteration, enabled bidirectional catalysis in enantiocomplementary synthesis of chiral β‐nitroalcohols. BmHNL catalyzed promiscuous Henry (24 examples) and retro‐Henry reaction (22 examples) provided up to >99% and 50% conversion to (S)‐ and (R)‐β‐nitroalcohols respectively, while both cases displayed up to >99% ee. The broad substrate scope and high stereoselectivity of BmHNL represents its synthetic applications in sustainabl… Show more
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