A single dose of UV radiation suppresses delayed type hypersensitivity responses to alloantigens and prolongs heart allograft survival in mice

Mottram, Patricia L.; Mirisklavos, A; Clunie, G. J. A.; Noonan, Frances P.

doi:10.1038/icb.1988.49

Cited by 27 publications

(25 citation statements)

References 26 publications

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“…The number of ISC in the head kidney, a major immunoglobulin-synthesizing organ in fish, did not change as a result of the UV treatment. This suggests that it was mainly T-cell responses that were affected by UVB irradiation here, which is consistent with the results of mammalian studies (25,60).…”

Section: Lymphocyte Functions and Plasma Igmsupporting

confidence: 91%

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Effects of Short- and Long-term Ultraviolet B Irradiation on the Immune System of the Common Carp (Cyprinus carpio)¶

Markkula

Salo

Immonen

et al. 2005

Photochem Photobiol

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Carp (Cyprinus carpio) were repeatedly exposed to 0, 60, 120 and 240 mJ/cm2 ultraviolet B (UVB) radiation three times in 1 week (short-term exposure) or 12 times in 4 weeks (long-term exposure). The effect of UVB on the functioning of the carp immune system was studied on day 2 after the final irradiation. After short-term UVB exposure, the whole-blood respiratory burst and cytotoxic activity were markedly enhanced, with parallel responses in both the number of circulating granulocytes and in the plasma cortisol concentration of the fish. These changes were not detectable after long-term exposure. The respiratory burst by head kidney granulocytes was suppressed dose dependently after both exposures, but cytotoxic activity was not affected. Exposure to UVB also modulated lymphocyte functions: nonstimulated and PHA-stimulated proliferation of head kidney lymphocytes in vitro was enhanced by both short-term and long-term exposure. LPS-stimulated proliferation was not affected by exposure nor was the number of immunoglobulin-secreting cells in the head kidney. In long-term exposure, the highest dose reduced the level of plasma IgM. This study indicates that UVB irradiation induces immunomodulation in the blood and head kidney of the carp and that the effects of short- and long-term exposure differ from each other. The results emphasize the potentially harmful impact of increased solar UVB radiation on fish immune functions.

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Section: Lymphocyte Functions and Plasma Igmsupporting

confidence: 91%

“…The main targets of UVB are the T-cell-mediated immune functions, e.g. delayed-type hypersensitivity and allograft rejection (25). A compromised immune defense against infections (26) and malignant tumors (27) has also been reported.…”

Section: Introductionmentioning

confidence: 99%

Effects of Short- and Long-term Ultraviolet B Irradiation on the Immune System of the Common Carp (Cyprinus carpio)¶

Markkula

Salo

Immonen

et al. 2005

Photochem Photobiol

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“…This suppression differs from the short‐term suppression observed in adults following UVR exposure. In contrast to neonatal UVR exposure where suppression is apparent at 8 weeks, studies in adult mice have shown suppression for only up to 2 weeks post‐irradiation 23 , 49 . In addition, the level of suppression observed in this study was lower than observed in adult studies.…”

Section: Discussionmentioning

confidence: 99%

Neonatal exposure to UVR alters skin immune system development, and suppresses immunity in adulthood

et al. 2011

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Neonates have a developing immune response, with a predisposition towards induction of tolerance. As the immune system develops, immunity rather than tolerance is induced, with this development of immunity occurring in response to external factors such as the environment. As ultraviolet radiation (UVR) suppresses immunity, it is likely that the effect of UVR on the neonatal immune system would be augmentation of the suppressive response. In support, childhood exposure to UVR has been linked with an increased incidence of melanoma; consistent with an increase in suppression. To address this, phenotypic and functional immune system studies were undertaken at 8 weeks after one single exposure of solar-simulated UVR to mice, when mice had reached adulthood. Subtle changes were observed in cell populations resident in the skin-draining lymph nodes (LNs) and there also appeared to be a subtle, but not statistically significant, increase in the production of interleukin-10 and interferon-c. Importantly, these changes also corresponded with significant suppression of the contact hypersensitivity response in irradiated mice compared with their control counterparts. This suppression was apparent when antigen sensitisation occurred during the neonatal or adult period, and thus did not appear to be analogous to UVR-induced suppression in adults. Although the percentage of T regulatory cells was increased in the skin-draining LNs, they were induced in a different manner to those induced following adult UVR exposure, with no increase in function on a per-cell basis. It therefore appears that one single neonatal exposure to UVR alters development of the immune system, leading to long-term implications for induction of immunity.

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“…Irradiation of mice with ultraviolet B (UVB; 290-320 nm) initiates a suppression of delayed-type hypersensitivity (DTH) and contact hypersensitivity (CHS) responses (Giannini 1986;Howie et al 1986;Mottram et al 1988;Noonan et al 1981a;Streilein and Bergstresser 1988;Yasumoto et al 1987) which is both dose and wavelength dependent (De Fabo and Noonan 1983;Noonan et al 1981 a). Immunosuppression occurs with biologically relevant doses of UVB which are readily available from natural sunlight ).…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to immunosuppression by ultraviolet B radiation in the mouse

Noonan

Hoffman²

1994

Immunogenetics

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Irradiation with ultraviolet B (UVB; 290-320 nm) initiates systemic immunosuppression of contact hypersensitivity (CHS). UV dose-responses for suppression of CHS to trinitrochlorobenzene were established in 18 strains of inbred mice. Three phenotypes with significantly different susceptibilities to UV suppression were identified. The phenotypes were: high (HI) susceptibility, 50% suppression with 0.7-2.3 kJ/m2 UV (C57BL/6, C57BL/10, and C57L and NZB females); low (LO) susceptibility, 50% suppression with 9.6-12.3 kJ/m2 UV (BALB/c, AKR, SJL and NZW), and intermediate (INT) susceptibility, 50% suppression with 4.7-6.9 kJ/m2 UV (DBA/2, C57BR, C3H/HeJ, C3H/HeN, CBA/N and A/J). UV suppression was not correlated with skin pigmentation or with the magnitude of the CHS response in non-irradiated animals. Major histocompatibility complex (MHC) haplotype was not correlated with UV suppression in MHC congenic strains B10.D2/oSnJ, B10.D2/nSnJ, B10.BR/SgSnJ, and A.BY/SnJ. There were no sex differences in UV suppression in BALB/c, C57BL/6, or NZW animals. In the autoimmune NZB strain, however, male mice (LO) were seven times less sensitive to UV suppression than NZB female mice (HI). Both sexes of (NZB x NZW)F1 and (NZW x NZB)F1 mice were HI, supporting dominance of HI over LO. Thus there are genetic factors and interacting sex-limited factors determining susceptibility to UV suppression. These findings may be of relevance to UV-related diseases such as photosensitive lupus and skin cancer.

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A single dose of UV radiation suppresses delayed type hypersensitivity responses to alloantigens and prolongs heart allograft survival in mice

Cited by 27 publications

References 26 publications

Effects of Short- and Long-term Ultraviolet B Irradiation on the Immune System of the Common Carp (Cyprinus carpio)¶

Effects of Short- and Long-term Ultraviolet B Irradiation on the Immune System of the Common Carp (Cyprinus carpio)¶

Neonatal exposure to UVR alters skin immune system development, and suppresses immunity in adulthood

Susceptibility to immunosuppression by ultraviolet B radiation in the mouse

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