A single dose of caffeic acid phenethyl ester prevents initiation in a medium-term rat hepatocarcinogenesis model

Abstract

Our results demonstrated that CAPE possesses anti-genotoxic and antineoplastic capabilities, by an anti-oxidative and free-radical scavenging mechanism.

Cancer Prevention Mediated by Caffeic Acid Phenethyl Ester Involves Cyp2b1/2 Modulation in Hepatocarcinogenesis

“…Chemoprotective agents regulate the expression of drug-metabolizing enzymes because their activity may contribute to the sensitivity of different individuals to develop cancer (Moon et al 2006;Ragin et al 2010). Confirming the effects of CAPE on a specific CYP will help us elucidate the mechanism of CAPE as a chemoprotective agent in the modified resistant hepatocyte model of hepatocarcinogenesis, which may become a referent model (Bai et al 2011;Beltran-Ramirez et al 2008;Beltran-Ramirez et al 2010;Carrasco-Legleu et al 2006). Different effects have been observed for CAPE as a chemoprotective agent.…”

“…Male Fischer-344 rats were treated according to the modified resistant hepatocyte model of Semple-Robert (Carrasco- Legleu et al 2006). Animals were administered with one ip dose of 200 mg/kg of DEN at day 0, then, on days 7, 8, and 9 with one daily dose by gavage of 2-acethylaminofluorene, and on day 10, each animal underwent a partial hepatectomy.…”

Regulation of Apoptosis, Invasion and Angiogenesis of Tumor Cells by Caffeic Acid Phenethyl Ester

“…CAPE has been used in folk medicine as a potent antibacterial, anti-inflammatory, antioxidant, antitumor and antiproliferative with a wide variety of biological and pharmacological activities at nontoxic concentrations in a mammal's organs [18]. CAPE is chemopreventive against intestinal, colon and skin cancer, and also has been shown to decreases the formation of preneoplastic hepatic lesions when is administrated in a rat model of liver carcinogenesis [19][20][21], but the mechanism of these properties is not completely understood. Recently, CAPE, in a concentration dependent fashion, was shown to inhibit MCF-7 (hormone receptor positive, HR+) and MDA-MB-231 (a model of triple negative BC (TNBC)) tumor growth, either in vitro or in vivo without much effect on normal mammary cells [22].…”

Searching for Analogues of the Natural Compound, Caffeic Acid Phenethyl Ester, with Chemprotective Activity

“…It has shown activities as antibacterial, antiinflammatory, antioxidant, antitumor and antiproliferative. CAPE is chemopreventive against intestinal, colon and skin cancer, and has shown to decreases the formation of preneoplastic hepatic lesions when is administered on a rat model of liver carcinogenesis (Carrasco-Legleu et al, 2004;Carrasco-Legleu et al, 2006) but the mechanism for these properties is not completely known. Besides CAPE, other caffeic acid esters in propolis may have biological effects; here we focus on CAPE and structurally related compounds.…”

“…of 2-acetyl-aminofluorene (2-AAF) at days 7, 8 and 9, and is performed a partial hepatectomy at 10th day. In addition, using histoenzimatic staining for gamma-glutamyl-tranpeptidasa (GGT) and Glutation-Stransferasa (GST-p) as markers of preneoplastic lesions (Carrasco-Legleu et al, 2004;Carrasco-Legleu et al, 2006) was determined that the highest number of preneoplastic lesions in rat liver is reached between 25 and 30 days after start the treatment, and lead to tumor after one year of the treatment.…”