A single dose desensitization for summer hay fever

Fell, Patrick J.; Brostoff, Jonathan

doi:10.1007/bf00314808

Cited by 25 publications

(8 citation statements)

References 15 publications

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“…We considered other possible explanations for finding no treatment effect for enzyme potentiated desensitisation whereas six other placebo controlled studies have had positive findings,4 7 – 11 but we were unable to reach a conclusion. Our study population seems to have been of similar average age, although insufficient data were available from the other studies to allow us to establish if the participants were more severely affected or if they were more likely to be sensitive to multiple pollens.…”

Section: Discussionmentioning

confidence: 82%

“…Each active injection was in the same form and dosage as had been given in the previously reported trials of enzyme potentiated desensitisation in hay fever 4 7 – 11. This consisted of 200 Fishman units of β glucuronidase (derived from the mollusc Haliotis ), 50 pg of 1,3-cyclohexanediol, 50 ng of protamine sulphate, and mixed inhaled allergen extracts (pollen mixes for trees, grasses, and weeds; a mix of allergenic mould spores; cat and dog danders; dust and storage mites) in a total volume of 0.05 ml of buffered saline.…”

Section: Methodsmentioning

confidence: 99%

“…Although it has been in clinical use for a range of allergic conditions for more than 20 years, enzyme potentiated desensitisation was first proposed as a simple, effective, and safe low dose method of multiple pollen desensitisation for seasonal rhinitis in 1990 4. Investigations, including dose finding studies, in mice and humans had previously established that β glucuronidase possesses immune modulating properties in conjunction with certain activators and in the presence of small doses of allergen 5 6.…”

Section: Introductionmentioning

confidence: 99%

“…Three of these studies involved participants with predominant grass pollen allergy,4 7 8 and a further three involved participants with a clinically relevant allergy to more than one type of pollen 9 – 11. Each study found a significant difference in at least one out of three outcome measures (symptom scores, symptom-free days, and recourse to symptom relieving drugs), and one study found significant benefit across all three.…”

Section: Introductionmentioning

confidence: 99%

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Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study

Radcliffe

Lewith²,

Turner³

et al. 2003

BMJ

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Objective To assess the efficacy of enzyme potentiated desensitisation in the treatment of severe summer hay fever poorly controlled by pharmacotherapy. Design Double blind randomised placebo controlled parallel group study. Setting Hospital in Hampshire. Participants 183 participants aged between 18 and 64 with a history of severe summer hay fever for at least two years; all were skin prick test positive to timothy grass pollen. 90 randomised to active treatment; 93 randomised to placebo. Interventions Active treatment: two injections of enzyme potentiated desensitisation, given between eight and 11 weeks apart, each comprising 200 Fishman units of glucuronidase, 50 pg 1,3-cyclohexanediol, 50 ng protamine sulphate, and a mixed inhaled allergen extract (pollen mixes for trees, grasses, and weeds; allergenic fungal spores; cat and dog danders; dust and storage mites) in a total volume of 0.05 ml of buffered saline. Placebo: two injections of 0.05 ml buffered saline solution. Main outcome measures Proportion of problem-free days; global rhinoconjunctivitis quality of life scores assessed weekly during pollen season. Results The active treatment group and the placebo group did not differ in the proportion of problem-free days, quality of life scores, symptom severity scores, change in quantitative skin prick provocation threshold, or change in conjunctival provocation threshold. No clinically significant adverse reactions occurred. Conclusions Enzyme potentiated desensitisation showed no treatment effect in this study.

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Section: Discussionmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study

Radcliffe

Lewith²,

Turner³

et al. 2003

BMJ

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“…Several small but poorly reported RCTs using EPD based on mixed inhalant allergens suggested effectiveness in seasonal allergic rhinitis due to grass pollen [12–15] and childhood house dust mite allergy [16], although a larger and more fully reported clinical trial failed to confirm the results for seasonal allergic rhinitis [17]. Single studies have shown positive results using mixed food allergens for childhood attention deficit disorder [18] and childhood migraine [19].…”

Section: Introductionmentioning

confidence: 99%

A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites

Berkovitz

Hill

Radcliffe³

et al. 2012

Journal of Allergy

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Primary Objective. To test the hypothesis that two injections of enzyme-potentiated mosquito antigen significantly reduce the size of experimental mosquito bites in participants with LLR-MB. Design. Randomised, double-blind, placebo-controlled, parallel group comparison over 3 months. Setting. Hospital outpatient clinic. Participants. Fifty adult participants of both sexes. Interventions. Two injections of mosquito antigen or matching placebo, 6 weeks apart. Main Outcome Measures. Early (1 hour) and late (24 hours) mean square root of erythema area (SREA) following controlled mosquito bite with the second bite given at least 6 weeks following the final injection. Results. At 1 hour, mean SREA was slightly higher in the EPD group compared to placebo after adjusting for baseline values (0.46, 95% CI −6.11 to 7.03), but this was not statistically significant (P = 0.89, ANCOVA analysis); neither were the results at 24 hours (−2.58, 95% CI −11.73 to 6.57) (P = 0.57). The proportion of participants experiencing a decrease in wheal size at 1 or 24 hours was similar between groups. Conclusions. EPD was not demonstrated to be effective for immediate or delayed LLR-MB. Methodological problems included a high variability in LLR-MB between subjects, suggesting that a crossover design should be used in future.

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Allergen injection immunotherapy for seasonal allergic rhinitis

Calderón

Alves

Jacobson

et al. 2007

Cochrane Database of Systematic Reviews

516

430

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Background Allergic rhinitis is the most common of the allergic diseases. Despite improved understanding of the pathophysiology of allergic rhinitis and advances in its pharmacological treatment, its prevalence has increased worldwide. For patients whose symptoms remain uncontrolled despite medical treatment, allergen injection immunotherapy is advised. An allergen-based treatment may reduce symptoms, the need for medication and modify the natural course of this disease. Objectives To evaluate the e icacy and safety of subcutaneous specific allergen immunotherapy, compared with placebo, for reducing symptoms and medication requirements in seasonal allergic rhinitis patients.

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A single dose desensitization for summer hay fever

Abstract: A new type of desensitising vaccine, enzyme potentiated was subjected to a double-blind randomised study during the hay fever season. The vaccine is a convenient single injection given in March and the results show good protection throughout the grass pollen season.

Cited by 25 publications

References 15 publications

Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study

Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study

A Randomised, Double-Blind Pilot Study of Enzyme-Potentiated Desensitisation for Prophylaxis of Large Local Reactions to Mosquito Bites

Allergen injection immunotherapy for seasonal allergic rhinitis

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