A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men

Hillmann, Kathrin; Bartels, Natalie Garcia; Kottner, Jan; Stroux, Andrea; Canfield, Douglas; Blume-Peytavi, Ulrike

doi:10.1159/000375320

Cited by 25 publications

(41 citation statements)

References 13 publications

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“…Many of the clinical trials evaluating the effectiveness of hair growth promotion monitor the subjects for 24-26 weeks [13,41]. Yet of the 12 studies reviewed, 2 evaluated subjects through a short period of 12 weeks [35,37], another one for 3 months [12].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

Cervantes

Perper

Wong

et al. 2017

Skin Appendage Disord

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Androgenetic alopecia (AGA) is a hair loss disorder affecting 80% of men and 50% of women throughout their lifetime. Therapies for AGA are limited and there is no cure. There is a high demand for hair restoration. Platelet-rich plasma (PRP), a treatment modality shown to promote wound healing, has also been explored as a treatment for AGA. This literature review wasconducted to assess the effectiveness of PRP treatment for AGA. Twelve studies conducted from 2011 to 2017 were evaluated and summarized by study characteristics, mode of preparation, and treatment protocols. A total of 295 subjects were given PRP or control treatment in these studies, and evaluated for terminal hair density, hair quality, anagen/telogen hair ratio, keratinocyte proliferation, blood vessel density, etc. Some studies also provided subject self-assessment reports. Most of the studies reviewed showed effectiveness of PRP in increasing terminal hair density/diameter. Additional investigations are needed to determine the optimal treatment regimen for high efficacy of PRP in AGA.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

Cervantes

Perper

Wong

et al. 2017

Skin Appendage Disord

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“…КлиничесКая дерматология и венерология 6,2016 бы на повышенную утомляемость, снижение рабо-тоспособности, апатию, бессонницу, т.е. проявле-ния сниженного качества жизни.…”

Section: специальные исследованияunclassified

“…В 2015 г. в исследовании K. Hillmann и соавт. [6] продемон-стрирован статистически достоверный прирост терминальных волос в теменной зоне на фоне при-менения 5% миноксидила. Позитивный стабилизи-рующий эффект сохранялся на протяжении 104 нед препарата [16].…”

Section: специальные исследованияunclassified

“…На фоне лечения разница в толщине отдельных терминальных волос станови-лась достоверно менее выраженной, причем поло-жительная динамика наблюдалась независимо от анатомической локализации, что соответствовало результатам исследования K. Hillmann и соавт. [6].…”

Section: специальные исследованияunclassified

“…Как 5%, так и 2% концентрации испытываемого лосьона были достоверно более эффективны в отношении приро-ста анагеновых волос в сравнении с плацебо (р<0,001), что характеризуется увеличением числа волос на фототрихограммах относительно началь-ных показателей [6][7][8]. Результаты клинических ис-пытаний 5% миноксидила в форме аэрозоля (пены) у женщин с АГА показали высокую эффективность и безопасность препарата, сопоставимые с 2% рас-твором миноксидила [9].…”

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Phototrichogram as a tool to assess the effectiveness of minoxidil therapy in patients with androgenetic alopecia

Вавилов¹,

Tsimbalenko²,

Kaverina³

2016

Klin. dermatol. venerol.

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андрогенетическая алопеция -генетически детерминированный хронический процесс миниатюризации фолликулов теменной зоны под действием андрогенов. В качестве основного диагностического метода, выявляющего морфо-метрические изменения волос, характерные для аГа, в рутинной трихологической практике чаще всего применяется фототрихограмма. Топические формы препарата миноксидил на сегодняшний день остаются основным фармакологи-ческим вариантом лечения андрогенетической алопеции. исследования продемонстрировали высокую эффективность препарата в отношении увеличения толщины волос в лобно-теменной зоне. однако в большинстве из этих работ учтены лишь некоторые из диагностически значимых критериев фототрихограмм. В проведенном исследовании была про-анализирована динамика показателей фототрихограмм на фоне терапии 5% пеной миноксидила, а также их связь с качеством жизни пациентов. androgenetic alopecia (aga) is the genetically determined androgen-induced chronic miniaturization of follicles in the parietal region. The phototrichogram technique is the main diagnostic tool identifying morphometric changes in hair typical of aga that is used most commonly in trichological practice. Today, topical forms of minoxidil remain the primary pharmacological treatment for androgenetic alopecia. research results have shown high efficacy of this pharmaceutical in increasing hair thickness at the frontoparietal region. however, in most of these studies, only some of the diagnostically relevant criteria of phototrichogram were taken into account. The study analyzed the dynamics of phototrichogram indexes during therapy with 5% minoxidil foam, as well as their relationship with the quality of life of patients.

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Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients

et al. 2022

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IMPORTANCEThere are knowledge gaps regarding the relative efficacy of 3 commonly used drugs for androgenetic alopecia (AGA), namely, minoxidil and the two 5-α reductase inhibitors dutasteride and finasteride.OBJECTIVE To examine the relative efficacy of any dose and administration route of minoxidil, dutasteride, and finasteride for the treatment of male AGA. DATA SOURCES Systematic searches were performed in PubMed on March 5, 2021, without date restrictions.STUDY SELECTION Eligible studies included those that investigated monotherapy with any dose and administration route of minoxidil, dutasteride, and finasteride.DATA EXTRACTION AND SYNTHESIS Data on the mean (SD) difference and sample size were used for the bayesian network meta-analyses. League tables and surface under the cumulative ranking curve values were used to examine the relative efficacy of the interventions. MAIN OUTCOMES AND MEASURESStudy end points were change in total and terminal hair count after 24 and 48 weeks of therapy. The 4 end points were quantified in hairs per square centimeters. RESULTSThe PubMed search yielded 848 records; after the 2 stages of screening, 23 studies were eligible for quantitative analyses. Mean (SD) age of patients ranged from 22.8 (3.3) years to 41.8 (12.3) years. The greatest increase in total hair count at 24 weeks (ie, first end point) was with 0.5 mg/d of dutasteride, which was significantly more efficacious than 1 mg/d of finasteride (mean difference, 7.1 hairs/cm 2 ; 95% CI, 5.1-9.3 hairs/cm 2 ) and minoxidil (0.25 mg/d [mean difference, 23.7 hairs/cm 2 ; 95% CI, 9.5-38.0 hairs/cm 2 ], 5 mg/d [mean difference, 15.0 hairs/cm 2 ; 95% CI, 3.9-26.1 hairs/cm 2 ], and 2% solution [mean difference, 8.5 hairs/cm 2 ; 95% CI, 4.8-12.3 hairs/cm 2 ]). The greatest increase in terminal hair count at 24 weeks (ie, second end point) was with 5 mg/d of minoxidil, which was significantly more efficacious than the 0.25-mg/d dose (mean difference, 43.6 hairs/cm 2 ; 95% CI, 29.7-57.7 hairs/cm 2 ) and its topical forms (in 2% [mean difference, 29.3 hairs/cm 2 ; 95% CI, 21.1-37.5 hairs/cm 2 ] and 5% [mean difference, 29.8 hairs/cm 2 ; 95% CI, 19.7-39.8 hairs/cm 2 ]); 5 mg/d of minoxidil was significantly more efficacious than 1 mg/d of finasteride (mean difference, 10.4 hairs/cm 2 ; 95% CI, 2.2-18.6 hairs/cm 2 ). The greatest increase in total hair count at 48 weeks (ie, third end point) was with 5 mg/d of finasteride, which was significantly more efficacious than 2% topical minoxidil (mean difference, 20.7 hairs/cm 2 ; 95% CI, 9.5-31.9 hairs/cm 2 ). The greatest increase in terminal hair count at 48 weeks (ie, fourth end point) was with 1 mg/d of finasteride, which was significantly more effective than topical minoxidil (in 2% [mean difference, 32.1 hairs/cm 2 ; 95% CI, 23.9-40.3 hairs/cm 2 ] and 5% [mean difference, 26.2 hairs/cm 2 ; 95% CI, 16.2-36.2 hairs/cm 2 ]). CONCLUSIONS AND RELEVANCEAs efficacy data from head-to-head trials accumulate, there could be a better sense of the relative efficacy of the different doses of the 5-...

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A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men

Cited by 25 publications

References 13 publications

Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

Phototrichogram as a tool to assess the effectiveness of minoxidil therapy in patients with androgenetic alopecia

Relative Efficacy of Minoxidil and the 5-α Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients

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