A single centre experience of squamous cell carcinoma of the upper limb requiring digital or hand amputation and review of literature

The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma

“…Chronic exposure to radiations, arsenic, or polycyclic hydrocarbons is also associated with the risk of developing cSCC [6]. Immunosuppression is an important factor, as the prevalence of cSCC in immunocompromised individuals is much higher than in immunocompetent ones [4,7]. There are numerous studies which attest the role of human papillomavirus (HPV) in the development of SCC on mucous membranes [8].…”

A rare case of squamous cell carcinoma of the index finger’s tip with an unusual presentation

“…The occurrence of SCC in the hand is rare, and it is even more rarely encountered in the digits of humans. 1,2,3,4,5,6,7,8 However, it is more prevalent in domestic animals such as dogs and cats' digits. 9 This case is, by far, the most dramatic and advanced presentation in this rare anatomical location for a SCC.…”

Is radiation therapy as a primary treatment modality for squamous cell carcinoma of the hand the best choice? Case series and review of the literature

“…Using excision margins of 6-10mm for high risk lesions and 4mm for all others, histological tumor clearance is achieved in 95% of cases, equating to a 92% 5-year cure rate [6]. Outcomes for SCC of the upper limb are generally less favorable, with recurrence rates estimated between 2-18% [2,7,8]. Although any surgery on the upper limb can be undertaken utilizing regional anesthesia, of course surgery can lead to significant loss of function in cases of radical excision or amputation.…”