A Single Center Experience in 266 Patients of Infantile Malignancies

Das, Umesh; Appaji, L.; Kumari, Babita; Lakshmaiah, K C; Padma, M.; Kavitha, S.; Sathyanarayanan, Vishwanath

doi:10.3109/08880018.2013.852644

Cited by 3 publications

(9 citation statements)

References 22 publications

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“…In the present study, infantile solid tumors constituted 7.3% (60 cases) of all pediatric solid tumors (835 cases) reported in the cytopathology division of our department during the study duration. The current study considered only the cytological diagnosis as compared to other studies which included cytological and histopathological diagnoses of infantile malignancies 2,7‐8 . Present study showed NB as the most common solid malignancy in infancy (25%) which is consistent with the literature 1,2,7‐8 …”

Section: Discussionsupporting

confidence: 88%

“…Earlier, Das et al from the pediatric oncology unit of our Institute had conducted a statistical study from 2003 to 2012. They reported 266 cases of infantile malignancies, of them, 193 cases were solid tumors 7 . In the present study, infantile solid tumors constituted 7.3% (60 cases) of all pediatric solid tumors (835 cases) reported in the cytopathology division of our department during the study duration.…”

Section: Discussionsupporting

confidence: 50%

“…They reported 266 cases of infantile malignancies, of them, 193 cases were solid tumors. 7 In the present study, infantile solid tumors constituted 7.3% (60 cases) of all pediatric solid tumors (835 cases) reported in the cytopathology division of our department during the study duration. The current study considered only the cytological diagnosis as compared to other studies which included cytological and histopathological diagnoses of infantile malignancies.…”

Section: Discussionmentioning

confidence: 50%

“…In the present study, FNAC of infant solid tumors encompassed a wide range of diagnoses commonly encountered in clinical practice. The cytomorphological interpretation was given based on cytological criteria illustrated in the literature for diagnosis of common and uncommon solid tumors of infancy and childhood 1,7,16‐18 . Ancillary studies like IHC on CB and CGs performed on aspirated material were useful in the specific classification of a broad category of SRCT, confirmation of morphological diagnoses in difficult cases, and provided helpful information related to prognosis and treatment 13,16,19 …”

Section: Discussionmentioning

confidence: 99%

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Diagnosis of solid tumors in infants by fine‐needle aspiration cytology: 5 years retrospective study from a tertiary care oncology center in South India

MukundaPai

Agrawal

Nargund

et al. 2021

Diagnostic Cytopathology

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Introduction Neuroblastoma (NB), Wilms tumor (WT), hepatoblastoma (HBL), germ cell tumors (GCT), rhabdomyosarcoma (RMS), and so forth are the commonly identified solid tumors in infants. Invasive diagnostic techniques are more challenging in infants than older children. fine needle aspiration cytology (FNAC) is a safe, minimally invasive and outpatient procedure which is time and cost‐effective for solid tumor diagnosis. This study aims to evaluate the role of FNAC in the diagnosis of various infantile solid tumors. Methods In this retrospective study, 61 cases of FNA of infant solid tumors were retrieved from the cytology archives over a period of 5 years from January 2013 to December 2017. Cytomorphology was studied and immunohistochemistry on cell block was performed wherever feasible. Histopathological correlation was done in 19 cases. Results Of the 61 cases studied, 60 cases were included in the study of which 35 were male and 25 were female. Infantile solid tumors constituted 7.3% of all pediatric solid tumors reported in cytopathology division of our Institute. The most common final diagnosis was NB (15, 25%) followed by HBL (13, 21.6%), WT (10, 16.6%), RMS (nine, 15%) and GCT (nine, 15%). The commonest site was abdominal‐pelvic (42, 70%). A definitive independent diagnosis could be made on FNA in 48 cases (80%). Follow‐up was done for 1.5 to 4 years (mean 26 months). The highest and lowest mortality was noted in NB (64.3%) and WT (12.5%) respectively. Conclusion This study concludes that FNAC can be adopted as a diagnostic modality in infant solid tumors.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

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Diagnosis of solid tumors in infants by fine‐needle aspiration cytology: 5 years retrospective study from a tertiary care oncology center in South India

MukundaPai

Agrawal

Nargund

et al. 2021

Diagnostic Cytopathology

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“…MDS is a clonal preleukemic disease state with cytopenia due to underproduction, abnormal differentiation, increased apoptosis, and varying degrees of leukemic blasts and carries a high risk of progression to leukemia. The incidence of both MDS and AML increases with age (7), but both can present in early childhood (8,9).…”

Section: Introductionmentioning

confidence: 99%

Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure

Heidemann¹,

Bursic²,

Zandi³

et al. 2020

JCI Insight

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The Outcome of Acute Lymphoblastic Leukemia in Infants at National Cancer Institute Egypt: 10 Years Experience

Ali,

Reda,

El Ashry

et al. 2023

International Journal of Cancer and Biomedical Research

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Background: Acute lymphoblastic leukemia (ALL) in infants is known to be biologically different from ALL in older children. Aim: We aimed to determine the clinical and laboratory characteristics, outcomes, and toxicities of infants with ALL treated with interfant-99 and St. Jude Total Therapy XV protocols at the National Cancer Institute (NCI), Egypt. Methods: This retrospective study included infants diagnosed with ALL between January 2010 and December 2019. Results: Of the total 40 cases, 25 (62.5%) were males, and 15 (37.5%) were females. Age at examination was < six months in 14 (35%) and ≥ six months in 26 (65%) cases. The total leukocyte count (TLC) at examination was >250 x10 3 in 11 (27.5%) cases. KMT2A rearrangement was done for 24 (60%) patients; it was wild-type in 5 (20%) and rearranged in 19 (80%) cases. 24 (60%) patients received Interfant-99, 14 (35%) received St. Jude total XV therapy, and 2 (5%) died on day 1. Relapse occurred in 10 (25%) patients. There was no difference in overall survival (OS) or event-free survival (EFS) between those treated with Interfant-99 versus St. Jude total XV therapy. The three-year OS was 26.3% for the whole group, and the three-year EFS was 14%. Conclusions: The patients had lower survival rates than those in the comparable studies in developed countries but are comparable to those in developing countries. Infection and sepsis, the leading causes of death, account for 78% of deaths, highlighting the importance of supportive care for such vulnerable patients.

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A Single Center Experience in 266 Patients of Infantile Malignancies

Cited by 3 publications

References 22 publications

Diagnosis of solid tumors in infants by fine‐needle aspiration cytology: 5 years retrospective study from a tertiary care oncology center in South India

Diagnosis of solid tumors in infants by fine‐needle aspiration cytology: 5 years retrospective study from a tertiary care oncology center in South India

Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure

The Outcome of Acute Lymphoblastic Leukemia in Infants at National Cancer Institute Egypt: 10 Years Experience

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