A Single-Center Evaluation of Environmental Emissions from ENDS and Combustible Cigarettes

Caraway, John W.; Jin, Tao; Schmidt, Eckhardt; Nelson, Paul R.

doi:10.2478/cttr-2021-0002

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…The authorization covered two versions of the Vuse Solo cartridge, designated as Generation 1 (G1) and Generation 2 (G2), both with Original (tobacco-flavored) e-liquids. Data supporting these applications included previously published clinical research with Vuse Solo G1 that demonstrated reduced abuse liability 22 , 23 , reduced environmental emissions 37 , and reduced biomarkers of exposure after short term use compared to continued use of CC 38 .…”

Section: Introductionmentioning

confidence: 99%

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

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et al. 2022

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Abuse liability (AL) of electronic nicotine delivery systems (ENDS) is relevant as the category increases in popularity as a potentially less-harmful alternative to cigarette smoking. AL assessments are important to the FDA in determining if a new product is appropriate for the protection of public health. This paper reports the results for Vuse Solo (G2 cartridge design) compared to high and low AL-comparators evaluated in an open-label, randomized crossover confinement AL study. The confinement design was adapted from previous ambulatory studies of Vuse Solo (G1 cartridge design) and included product familiarization sessions before each four-hour test session in which subjective measures, nicotine pharmacokinetics (PK), and physiological endpoints were assessed following a single 10-min ad libitum product use session. Product liking, intent to use again, suppression of urge to smoke, and nicotine PK were lower after use of Vuse Solo compared to cigarettes and higher after use of Vuse Solo compared to nicotine gum. No significant differences in blood pressure or heart rate were observed between the products pre- to post-product use. These data reinforce previous research and provide the scientific evidence to support regulatory decisions demonstrating that Vuse Solo has an AL profile lower than that of combustible cigarettes but higher than that of nicotine gum and, therefore, may be a suitable replacement for cigarette smoking for some adult smokers.

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Section: Introductionmentioning

confidence: 99%

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

Campbell

Jin

Round

et al. 2022

Sci Rep

Self Cite

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Comparison of the effects of three types of heating tobacco system and conventional cigarettes on indoor air quality

et al. 2021

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Environmental tobacco smoke (ETS) from conventional cigarettes is reported to affect indoor air quality (IAQ) in various real indoor environments. Recently, Japan Tobacco Inc. introduced three types of tobacco product that are heated rather than combusted. These comprise one direct heating tobacco system and two in-direct heating tobacco systems. In this study, the impact of using these products on IAQ was evaluated in an environmentally controlled chamber. Two environmental conditions, simulating restaurant and residential spaces, were examined. Under the same conditions, cigarette smoking and the presence of people only were used as positive and negative controls, respectively. The indoor air concentrations of 48 constituents (tobacco-specific nitrosamines, carbonyls, volatile organic compounds, total volatile organic compounds, polycyclic aromatic hydrocarbon, polycyclic aromatic amines, mercury, metals, ETS markers, propylene glycol, glycerol, carbon monoxide, carbon dioxide, suspended particle matter, ammonia, and nitrogen oxides) were measured. Compared with the presence of people, the concentrations of some constituents were actually increased when using heating tobacco products under both environmental conditions, simulating restaurant and residential spaces. However, the constituent concentrations were lower than those obtained by cigarette smoking, except for propylene glycol and glycerol, and below the exposure limits for constituents in air, as defined by air quality guidelines or regulations. Based on these data, the use of heating tobacco systems in appropriate indoor environments has less impacts compared to conventional cigarettes. Article Highlights We measured the indoor air concentrations of chemical constituents generated when using three heating tobacco systems with different heating mechanisms in two environment conditions simulating restaurant and residential spaces (positive control: when smoking cigarettes, negative control: the presence of people only). In the measurement and analysis method used this study, it was possible to find not only that the air concentration generated when using the heating tobacco systems in this study were considerably lower than that when smoking cigarettes, but also the differences of the concentrations between heating tobacco systems with different heating mechanisms. We showed some constituents which actually increased the air concentrations when using heating tobacco systems compared with the presence of people only.

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A Single-Center Evaluation of Environmental Emissions from ENDS and Combustible Cigarettes

Cited by 2 publications

References 48 publications

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

Part one: abuse liability of Vuse Solo (G2) electronic nicotine delivery system relative to combustible cigarettes and nicotine gum

Comparison of the effects of three types of heating tobacco system and conventional cigarettes on indoor air quality

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