A Single-Center, Double-Blinded, Randomized Controlled Study to Evaluate the Relative Efficacy of Sublingual and Oral Vitamin B-Complex Administration in Reducing Total Serum Homocysteine Levels

Yazaki, Yuka; Chow, Gigi; Mattie, Mark

doi:10.1089/acm.2006.12.881

Cited by 15 publications

(14 citation statements)

References 9 publications

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“…Cyanocobalamin is the most economical—and historically the most used form—rendering it suitable for safe daily use [45]. There were no apparent substantial differences between the absorption of sublingual and oral forms [152,206]. However, oral dissolution could be critical in the secretion of the salivary R-binder and its subsequent bond.…”

Section: Discussionmentioning

confidence: 99%

Vitamin B12 among Vegetarians: Status, Assessment and Supplementation

Rizzo¹,

et al. 2016

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Cobalamin is an essential molecule for humans. It acts as a cofactor in one-carbon transfers through methylation and molecular rearrangement. These functions take place in fatty acid, amino acid and nucleic acid metabolic pathways. The deficiency of vitamin B12 is clinically manifested in the blood and nervous system where the cobalamin plays a key role in cell replication and in fatty acid metabolism. Hypovitaminosis arises from inadequate absorption, from genetic defects that alter transport through the body, or from inadequate intake as a result of diet. With the growing adoption of vegetarian eating styles in Western countries, there is growing focus on whether diets that exclude animal foods are adequate. Since food availability in these countries is not a problem, and therefore plant foods are sufficiently adequate, the most delicate issue remains the contribution of cobalamin, which is poorly represented in plants. In this review, we will discuss the status of vitamin B12 among vegetarians, the diagnostic markers for the detection of cobalamin deficiency and appropriate sources for sufficient intake, through the description of the features and functions of vitamin B12 and its absorption mechanism.

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Section: Discussionmentioning

confidence: 99%

Vitamin B12 among Vegetarians: Status, Assessment and Supplementation

Rizzo¹,

et al. 2016

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“…In addition to oral dietary supplements, vitamin B12 is available in sublingual preparations as tablets or lozenges. These preparations are frequently marketed as having superior bioavailability 18,19 . Vitamin B12, in the form of cyanocobalamin and occasionally hydroxocobalamin, can be administered parenterally as a prescription medication, usually by intramuscular injection 17 .…”

Section: Resultsmentioning

confidence: 99%

Awareness of vitamin b12 deficiency among the general population

Packyanathan¹

2017

Int J Recent Sci Res

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ARTICLE INFO ABSTRACT Aim:To study the level of awareness on vitamin B12 deficiency among the general population and to educate the population on preventive measures. Objective: To study the causes, signs and symptoms, treatment, investigation and prevention of vitamin B12 deficiency among the general population and to educate the population on preventive measures. Background: Vitamin B12, or Cobalamin, is a water-soluble vitamin and plays a vital role in the normal functioning of the brain and the nervous system and in the formation of red blood cells. It also helps to regulate and synthesize DNA. It occurs in animal products, such as fish, meat, eggs, and dairy products. Vitamin B12 deficiency can result in irreversible and potentially severe damage, especially to the human nervous system and brain. It can also cause anemia.Reason: This study is done inorder to understand the role of vitamin B12 and also help in the prevention and better treatment of diseases associated with its deficiency leading to better quality of life.

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“…One study found that small doses of vitamin B 12 in the range of 0.1–0.5 µg resulted in absorption ranging between 52% and 97%; doses of 1 µg and 5 µg resulted in mean absorption of 56% and 28%, respectively, while higher doses had even lower absorption, with 10 µg and 50 µg doses resulting in 16% and 3%, respectively, being absorbed 17 . While sublingual supplements are often promoted as being more efficiently absorbed, there is no evidence to show that this form of supplement is superior to regular oral vitamin B 12 44 . Vitamin B 12 supplements are not made from animal‐based products and are suitable for inclusion in a vegan diet.…”

Section: Vitamin B12 In the Vegetarian Dietmentioning

confidence: 99%

Vitamin B12 and vegetarian diets

Zeuschner

Hokin

Marsh³

et al. 2013

Medical Journal of Australia

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Vitamin B12 is found almost exclusively in animal‐based foods and is therefore a nutrient of potential concern for those following a vegetarian or vegan diet. Vegans, and anyone who significantly limits intake of animal‐based foods, require vitamin B12‐fortified foods or supplements. Vitamin B12 deficiency has several stages and may be present even if a person does not have anaemia. Anyone following a vegan or vegetarian diet should have their vitamin B12 status regularly assessed to identify a potential problem. A useful process for assessing vitamin B12 status in clinical practice is the combination of taking a diet history, testing serum vitamin B12 level and testing homocysteine, holotranscobalamin II or methylmalonic acid serum levels. Pregnant and lactating vegan or vegetarian women should ensure an adequate intake of vitamin B12 to provide for their developing baby. In people who can absorb vitamin B12, small amounts (in line with the recommended dietary intake) and frequent (daily) doses appear to be more effective than infrequent large doses, including intramuscular injections. Fortification of a wider range of foods products with vitamin B12, particularly foods commonly consumed by vegetarians, is likely to be beneficial, and the feasibility of this should be explored by relevant food authorities.

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A Single-Center, Double-Blinded, Randomized Controlled Study to Evaluate the Relative Efficacy of Sublingual and Oral Vitamin B-Complex Administration in Reducing Total Serum Homocysteine Levels

Abstract: There was no statistically significant difference in serum tHcy concentrations between SL and PO groups either before or after treatment, substantiating the idea that there is no difference in efficacy between the two methods of vitamin complex delivery.

Cited by 15 publications

References 9 publications

Vitamin B12 among Vegetarians: Status, Assessment and Supplementation

Vitamin B12 among Vegetarians: Status, Assessment and Supplementation

Awareness of vitamin b12 deficiency among the general population

Vitamin B12 and vegetarian diets

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