A single center 14 years study of infectious complications leading to hospitalization of patients with primary antibody deficiencies

Mamishi, Setareh; Eghbali, Aiden Nasiri; Rezaei, Nima; Abolhassani, Hassan; Parvaneh, Nima; Aghamohammadi, Asghar

doi:10.1016/s1413-8670(10)70074-x

Cited by 12 publications

(3 citation statements)

References 22 publications

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“…Although selective IgA deficiency is a mild form of immunodeficiency, some patients develop a variety of significant clinical problems, such as CMC (70). Furthermore, Candida infections in individuals with Xlinked agammaglobulinemia (XLA), a mutation in the gene encoding for Bruton tyrosine kinase (BTK) which leads to impaired peripheral B cell maturation, have been described (71)(72)(73). Lymphoid cancers patients treated with ibrutinib, a BTK inhibitor, develop invasive fungal infections including candidemia (74).…”

Section: Discussionmentioning

confidence: 99%

Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity

2020

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The fungus Candida albicans colonizes the oral mucosal surface of 30-70% of healthy individuals. Due to local or systemic immunosuppression, this commensal fungus is able to proliferate resulting in oral disease, called oropharyngeal candidiasis (OPC). However, in healthy individuals C. albicans causes no harm. Unlike humans mice do not host C. albicans in their mycobiome. Thus, oral fungal challenge generates an acute immune response in a naive host. Therefore, we utilized C. albicans clinical isolates which are able to persist in the oral cavity without causing disease to analyze adaptive responses to oral fungal commensalism. We performed RNA sequencing to determine the transcriptional host response landscape during C. albicans colonization. Pathway analysis revealed an upregulation of adaptive host responses due to C. albicans oral persistence, including the upregulation of the immune network for IgA production. Fungal colonization increased cross-specific IgA levels in the saliva and the tongue, and IgA + cells migrated to foci of fungal colonization. Binding of IgA prevented fungal epithelial adhesion and invasion resulting in a dampened proinflammatory epithelial response. Besides CD19 + CD138 − B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans suggesting a potential role of B lymphocytes during oral fungal colonization. B cell deficiency increased the oral fungal load without causing severe OPC. Thus, in the oral cavity B lymphocytes contribute to control commensal C. albicans carriage by secreting IgA at foci of colonization thereby preventing fungal dysbiosis.

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Section: Discussionmentioning

confidence: 99%

Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity

2020

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“…Hypogammaglobulinemia or antibody deficiency is the major hallmark of PAD patients. Affected individuals share a clinical phenotype with common features, such as chronic and recurrent infections, chronic inflammation, and autoimmunity [2], leading to recurrent hospitalization and a decreased quality of life [3,4,5]. …”

Section: Introductionmentioning

confidence: 99%

Autoimmunity in Primary Antibody Deficiencies

Azizi¹,

Ahmadi²,

Abolhassani³

et al. 2016

Int Arch Allergy Immunol

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Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are associated with the various types of PAD. Both systemic and organ-specific autoimmune diseases could be attributed to B-cell defects in PAD patients. Immune thrombocytopenic purpura and autoimmune hemolytic anemia are the most common autoimmune disorders in this group of patients. The aim of this review is to describe the proposed mechanisms for autoimmunity and to review the literature with respect to the reported autoimmune disorders in each type of PAD.

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“…In Iran, pneumonia is the most common cause of hospitalization in the elderly and patients with primary antibody deficiencies (2, 3). Nonetheless, only 5% and 28% of patients with acute respiratory symptoms who are referred respectively to primary care physicians (4) and emergency departments (EDs) (5) develop pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Laboratory Findings in Patients With Acute Respiratory Symptoms That Suggest the Necessity of a Chest X-ray for Community-Acquired Pneumonia

et al. 2014

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Background:Pneumonia is a common illness in all parts of the world and is considered as a major cause of death among all age groups. Nevertheless, only about 5% of patients referring to their primary care physicians with acute respiratory symptoms will develop pneumonia.Objectives:This study was performed to derive practical criteria for performing chest radiographs for the evaluation of community-acquired pneumonia (CAP).Patients and Methods:A total of 420 patients with acute respiratory symptoms and positive findings on chest radiograph were evaluated from December 2008 to December 2009. The subjects were referred to outpatient clinics or emergency departments of Birjand's medical university hospitals, Iran, and were enrolled as positive cases. A checklist was completed for each patient including their demographic information, clinical signs and symptoms (cough, sputum production, dyspnea, chest pain, fever, tachycardia, and tachypnea), abnormal findings in pulmonary auscultation and laboratory findings (erythrocyte sedimentation rate, C-reactive protein levels, and white blood cell count). An equal number of age-matched individuals with acute respiratory symptoms, but insignificant findings on chest radiography, were included as the control group. Finally, the diagnostic values of different findings were compared.Results:The data showed that vital signs and physical examination findings are useful screening parameters for predicting chest radiograph findings in outpatient settings. Therefore, by implementing a prediction rule, we would be able to determine which patients would benefit from a chest X-Ray (sensitivity, 94% and specificity, 57%).Conclusions:This study's findings suggest that requesting chest radiographs might not be necessary in patients with acute respiratory symptoms unless the vital signs and/or physical examination findings are abnormal. Considering the 94% sensitivity of this rule for predicting CAP, a chest radiograph is required for patients with unreliable follow-ups or moderate to high likelihood of morbidity if CAP is not initially detected.

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A single center 14 years study of infectious complications leading to hospitalization of patients with primary antibody deficiencies

Cited by 12 publications

References 22 publications

Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity

Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity

Autoimmunity in Primary Antibody Deficiencies

Clinical and Laboratory Findings in Patients With Acute Respiratory Symptoms That Suggest the Necessity of a Chest X-ray for Community-Acquired Pneumonia

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