A Single-Center 10-Year Retrospective Analysis of Cryoablation for the Management of Desmoid Tumors

Yan, Yet Yen; Walsh, John P.; Munk, Peter L.; Mallinson, Paul I.; Simmons, Christine; Clarkson, Paul W.; Jayaram, Prem Ruben; Heran, Manraj K.S.; Ouellette, Hugue A.

doi:10.1016/j.jvir.2021.05.025

Cited by 12 publications

(23 citation statements)

References 28 publications

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“…7 studies recorded both the pre-ablation mean tumor diameter and volume [ 20 , 22 – 25 , 27 , 28 ], while 1 study recorded only the pre-ablation tumor volume [ 26 ] and 1 study only recorded pre-ablation tumor diameter [ 21 ]. Volume was assessed in different ways, either by an ellipsoid formula, a modified ellipsoid formula (½ x (length x width x height)), manual segmentation or automated software measurement.…”

Section: Resultsmentioning

confidence: 99%

“…Volume was assessed in different ways, either by an ellipsoid formula, a modified ellipsoid formula (½ x (length x width x height)), manual segmentation or automated software measurement. 2 studies utilised the ½ x (length x width x height) formula [ 20 , 27 ], 1 study utilised the ellipsoid formula [ 22 ], 3 studies utilised manual segmentation [ 23 , 25 , 28 ] and 1 study used IntelliSpace Discovery software platform (Philips Healthcare) semi-automatic 3D segmentation tool [ 26 ]. 1 study did not mention the method of volume measurement [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…The estimated pooled mean of pre-ablation tumor volume in the selected 8 studies is 133.22 cm3 (95% CI, 63.75–202.70; I 2 = 85.7%) ( Fig 2A ) [ 20 , 22 – 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…Patient selection criteria for cryoablation was heterogeneous among studies with palliative or curative intent. From the applicable studies, 79 and 61 patients were treated for curative and palliative intent respectively [ 20 , 22 , 23 , 25 , 27 , 28 ]. 38 patients underwent cryoablation as 1st line therapy and 191 patients underwent cryoablation as >1st line therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Image-guided interventional radiologic techniques such as alcohol injection and electroporation [ 14 ], high-intensity focused ultrasound [ 15 , 16 ], and percutaneous microwave and radiofrequency ablation have been used in the treatment of DT [ 17 – 19 ]. Cryoablation has recently been shown in studies to be efficacious and safe [ 20 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Cryotherapy in extra-abdominal desmoid tumors: A systematic review and meta-analysis

et al. 2021

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Introduction Desmoid tumor is a locally-invasive neoplasm that causes significant morbidity. There is recent interest in cryotherapy for treatment of extra-abdominal desmoid tumors. This systematic review assesses evidence on safety and efficacy of cryotherapy in the treatment of extra-abdominal desmoid tumors. Materials and methods The systematic review was conducted with reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Literature search was performed using MEDLINE and the Cochrane Central Register of Controlled Trials. 9 full text papers were reviewed and meta-analysis was performed for measures of safety, efficacy and symptom relief. Results The estimated pooled proportion of major and minor complications was 4.2% (95% CI, 1.8–9.6; I 2 = 0%) and 10.2% (95% CI, 5.7–17.8; I 2 = 0%) respectively. The estimated pooled proportion of non-progressive disease rate of all studies was 85.8% (95% CI, 73.4–93.0; I 2 = 32.9%). The estimated progression free survival rate at 1 year was 84.5% (95% CI:74.6–95.8) and 78.0% at 3 years (95% CI: 63.8–95.3). As for pain control, the estimated pooled proportion of patients with decrease in visual analogue scale (VAS) > = 3 for those with VAS > = 3 before treatment for 2 studies was 87.5% (95% CI, 0.06–100; I 2 = 71.5%) while 37.5% to 96.9% of patients were reported to have experienced partial or complete symptom relief in the other studies. Conclusion Cryotherapy is a safe and effective treatment modality for extra-abdominal desmoid tumors with efficacy similar to those treated with traditional strategies in the short to medium term.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The estimated pooled mean of pre-ablation tumor volume in the selected 8 studies is 133.22 cm3 (95% CI, 63.75–202.70; I 2 = 85.7%) ( Fig 2A ) [ 20 , 22 – 28 ].…”

Section: Resultsmentioning

confidence: 99%