A Single‐Cell Transcriptome Profiling of Triptolide‐Induced Nephrotoxicity in Mice
Jiangpeng Wu,
Jinan Guo,
Siyu Xia
et al.
Abstract:Triptolide (TP), an active component isolated from the traditional Chinese herb Tripterygium wilfordii Hook F (TWHF), shows great promise for treating inflammation‐related diseases. However, its potential nephrotoxic effects remain concerning. The mechanism underlying TP‐induced nephrotoxicity is inadequately elucidated, particularly at single‐cell resolution. Hence, single‐cell RNA sequencing (scRNA‐seq) of kidney tissues from control and TP‐treated mice is performed to generate a thorough description of the … Show more
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