A Single-Blinded, Randomized Pilot Study Evaluating Effects of Electroacupuncture in Diabetic Patients with Symptoms Suggestive of Gastroparesis

Wang, Chung Pang; Kao, Chia Hung; Chen, Wei Kung; Lo, Wan Yu; Hsieh, Ching Liang

doi:10.1089/acm.2008.0107

Cited by 88 publications

(113 citation statements)

References 26 publications

(32 reference statements)

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…EA or prokinetic agents are typically administered to alleviate the symptoms; however, patients may show different responses to the treatments. The findings of the present study suggested that EA significantly alleviates mild symptoms of gastroparesis and the results are consistent with those of previous studies (4,5,7). Among the 34 patients with early responses to EA treatment, 30 had mild symptoms, while only 3 patients had severe symptoms.…”

Section: Discussionsupporting

confidence: 93%

“…EA has been reported to improve or normalize gastric dysrhythmia via the vagal pathway, and to increase plasma pancreatic polypeptide levels in humans (4,7). Acupuncture restores the balance of parasympathetic and sympathetic nerves, the disturbance of which is considered to be the sole cause of gastrointestinal dysmotility in diabetes mellitus (18,19).…”

Section: Discussionmentioning

confidence: 99%

“…In previous years, electroacupuncture (EA) has been widely used to treat patients with symptoms suggestive of gastroparesis (4)(5)(6)(7)(8). EA has potential benefits for the control of disorders of gastrointestinal motility in a more systematic way compared with other alternative therapies (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…EA has potential benefits for the control of disorders of gastrointestinal motility in a more systematic way compared with other alternative therapies (9)(10)(11)(12). Three small, randomized pilot studies demonstrated that EA effectively alleviated the symptoms of diabetic gastroparesis; however, the overall efficiency was not satisfactory (4,6,7). The possible cause of the contrasting results may be a result of a failure to categorize the patients according to the severity of their symptoms (4,(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Three small, randomized pilot studies demonstrated that EA effectively alleviated the symptoms of diabetic gastroparesis; however, the overall efficiency was not satisfactory (4,6,7). The possible cause of the contrasting results may be a result of a failure to categorize the patients according to the severity of their symptoms (4,(6)(7)(8). A study by Wang (5) showed that the effect of acupuncture was superior to that of drug treatment (with respect to domperidone) in terms of symptom alleviation, with a total efficacy rate of 94%.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Electroacupuncture combined with mosapride alleviates symptoms in diabetic patients with gastroparesis

Pan

Wang

Tian

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. The present study compared the clinical effectiveness of electroacupuncture (EA), monotherapy and combination therapy involving the administration of EA and mosapride in diabetic patients with severe or mild symptoms suggestive of gastroparesis. A total of 56 patients with type 2 diabetes who had symptoms suggestive of gastroparesis for >3 months were divided into two groups according to the Gastroparesis Cardinal Symptom Index (GCSI) score, including 33 in the mild group (GCSI score <3.5) and 23 in the severe group (GCSI score ≥3.5). Initially, all patients received EA monotherapy for 14 days. An effective response was defined as a reduction of the overall baseline GCSI score by >25% after treatment. The non-responding patients then received a combination treatment with EA and mosapride. Gastric emptying was assessed by the 13 C-octanoic acid breath test at the beginning and end of each treatment session. Two patients in the severe group dropped out of the study during the initial treatment session. The results revealed that 34 early-responding patients (30 from the mild group and 4 from the severe group) treated with EA monotherapy, and 20 non-early-responding patients receiving combination therapy with EA and mosapride showed clinically significant improvements. Analysis of data from the mild subgroup demonstrated that EA treatment specifically improved symptoms of nausea, vomiting, stomach fullness, excessive fullness and bloating. There was no statistically significant difference in the gastric half-emptying time among patients prior to and after EA monotherapy. These preliminary results suggested that EA may be an option for improving mild symptoms in patients with diabetic gastroparesis, whereas combination therapy involving EA and pharmaceutics is required in patients with severe symptoms.

show abstract

Section: Discussionsupporting

confidence: 93%