A single-blind study of doxazosin in the treatment of essential hypertension when added to nonresponders to angiotensin-converting enzyme inhibitor therapy

Usefulness of the .ALPHA.1-Blocker Doxazosin as a Third-Line Antihypertensive Drug

“…In the previous studies, potent antihypertensive effects were observed when doxazosin was added to β-blockers, ACE inhibitors and/or CCBs (11)(12)(13)(14)(15)(16). Furthermore, the low dose range of doxazosin used as monotherapy as well as combination therapy has been reported to be free of side effects (5).…”

Tamsulosin: Real Life Clinical Experience in 19,365 Patients

“…Studies with classical α 1 -adrenoceptor antagonists (e.g. doxazosin and terazosin) have reported that their blood pressure-lowering effects may be enhanced in patients with concomitant antihypertensive treatment [15, 16, 17, 18, 19]. In normotensive patients with LUTS suggestive of BPO, these drugs can also cause blood pressure reductions which are small but significantly greater than with placebo [19, 20, 21].…”

Doxazosin in the current treatment of hypertension

“…It has been used in a variety of clinical trials, including various populations of hypertensive patients such as diabetics, the elderly, patients with benign prostatic hyperplasia or hypercholesterolaemia, the obese or Afro-Americans and in combination with all major groups of antihypertensive drugs such as: calciumchannel antagonists, diuretics, β -adrenoreceptor antagonists, ACEIs and ARBs [4,7,[10][11][12]14,17,19,20,22,24,[43][44][45][46][47][48] . In these studies, doxazosin in either standard or GITS formulation was added as a second-or third-line agent.…”