A single arm phase II study of a Far-Eastern traditional herbal formulation (sho-sai-ko-to or xiao-chai-hu-tang) in chronic hepatitis C patients

Deng, Gary; Kurtz, Robert C.; Vickers, Andrew J.; Lau, Nancy; Yeung, K. Simon; Shia, Jinru; Cassileth, Barrie R.

doi:10.1016/j.jep.2011.04.008

Cited by 51 publications

(36 citation statements)

References 39 publications

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“…Saikosaponins are the main active components of bupleurum root; these have anti-hepatitis, anti-nephritis, antihepatoma, anti-inflammation, immunomodulation, and antibacterial effects. TJ-9 has been studied for treatment of hepatitis B (75,76), showing some unconvincing positive effects; studies are underway to evaluate the herbal for the treatment of chronic hepatitis C (77). There are also studies to evaluate TJ-9 as treatment for hepatocellular carcinoma (78,79).…”

Section: Tj-9 (Xiao-chai-hu-tang In China; Sho-saiko-to In Japan)mentioning

confidence: 99%

Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms

et al. 2015

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Section: Tj-9 (Xiao-chai-hu-tang In China; Sho-saiko-to In Japan)mentioning

confidence: 99%

Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms

et al. 2015

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“…Viral load response was mixed, with seven patients showing reductions, ten showing increases and seven indeterminate due to assay limitations. Among the nine (38%) subjects who showed improvement in histology activity in a paired comparison of pre-and post-treatment liver biopsy, five (21%) showed an improvement of two points or greater, meeting the predefined criteria for 'response' [73]. The formulation was accepted to be promising.…”

Section: Are Herbal Medicines Better Than Ifn For the Prevention Of Hcc?mentioning

confidence: 95%

Basic answers to complicated questions for the course of chronic hepatitis C treatment

Örmeci

Erdem

2012

Expert Review of Gastroenterology & Hepatology

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Hepatitis C virus infection is a long-lasting disease, which causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma, thus leading to liver-related death. Currently, the optimal treatment for chronic hepatitis C infection is the combination of pegylated interferon and ribavirin. The aim of this review is to assess the long-term clinical outcomes of interferons alone or in combination with ribavirin in the management of chronic hepatitis C.

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“…Xiao-Chai-Hu-Tang (XCHT) is a formula consisting of 7 herbs that has been used to treat liver diseases in East Asia. In a phase II trial, XCHT was found to decrease levels of HCV (51). However, the investigators cited several limitations of their trial, such as sampling bias, inter-observer variability, slow accrual, and a high dropout rate.…”

Section: Extracts In and Formulations Of Tcms To Treat Hcvmentioning

confidence: 99%