For the lack of adequate paired noisy-clean speech corpus in many real scenarios, non-parallel training is a promising task for DNNbased speech enhancement methods. However, because of the severe mismatch between input and target speech, many previous studies only focus on magnitude spectrum estimation and remain the phase unaltered, resulting in the degraded speech quality under low signal-to-noise ratio conditions. To tackle this problem, we decouple the difficult target w.r.t. original spectrum optimization into spectral magnitude and phase, and propose a novel Cycle-in-cycle generative adversarial network (dubbed CinCGAN) to jointly estimate the spectral magnitude and phase information stage by stage. In the first stage, we pretrain a magnitude CycleGAN to coarsely denoise the spectral magnitude spectrum. In the second stage, we couple the pretrained CycleGAN with a complex-valued CycleGAN as a cycle-in-cycle structure to recover phase information and refine the spectral magnitude simultaneously. The experimental results on the VoiceBank + Demand show that the proposed approach significantly outperforms previous baselines under non-parallel training. Experiments on training the models with standard paired data also show that the proposed method can achieve remarkable performance.