2024
DOI: 10.1111/bcp.16002
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A simulation study on model‐informed precision dosing of amikacin for achieving target area under the concentration–time curve

Tomoyuki Yamada,
Kazutaka Oda,
Masami Nishihara
et al.

Abstract: AimsAmikacin requires therapeutic drug monitoring for optimum efficacy; however, the optimal model‐informed precision dosing strategy for the area under the concentration–time curve (AUC) of amikacin is uncertain. This simulation study aimed to determine the efficient blood sampling points using the Bayesian forecasting approach for early achievement of the target AUC range for amikacin in critically ill patients.MethodsWe generated a virtual population of 3000 individuals using 2 validated population pharmaco… Show more

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