A simulation study of the variability of indocyanine green kinetics and using structural<i>a priori</i>information in dynamic contrast enhanced diffuse optical tomography (DCE-DOT)

Ünlü, Mehmet; Birgül, Özlem; Gülşen, Gültekin

doi:10.1088/0031-9155/53/12/008

Cited by 10 publications

(8 citation statements)

References 41 publications

(44 reference statements)

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“…For 2D case, our results are compared with another analytical method while simulations obtained by using Finite Element Method are used to validate both 2D and 3D cases. These simulations are obtained by solving the diffusion equation numerically with the Comsol Multiphysics solver [12, 56– 58]. …”

Section: Numerical Application and Validationmentioning

confidence: 99%

An extended analytical approach for diffuse optical imaging

et al. 2015

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In this work, we introduce an analytical method to solve the diffusion equation in a cylindrical geometry. This method is based on an integral approach to derive the Green’s function for specific boundary conditions. Using our approach, we obtain comprehensive analytical solutions with the Robin boundary condition for diffuse optical imaging in both two and three dimensions. The solutions are expressed in terms of the optical properties of tissue and the amplitude and position of the light source. Our method not only works well inside the tissue but provides very accurate results near the tissue boundaries as well. The results obtained by our method are first compared with those obtained by a conventional analytical method then validated using numerical simulations. Our new analytical method allows not only implementation of any boundary condition for a specific problem but also fast simulation of light propagation making it very suitable for iterative image reconstruction algorithms.

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Section: Numerical Application and Validationmentioning

confidence: 99%

An extended analytical approach for diffuse optical imaging

et al. 2015

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“…In addition to regular phantom studies, due to significant improvement in data acquisition speed, for the first time, we were able to conduct a series of dynamic contrast enhanced DOT and MR-DOT phantom studies using indocyanine green (ICG) [5]. Our analysis shows that ICG kinetics curves obtained by the frequency domain DOT system have the potential to characterize the tumor permeability.…”

Section: Task 3 System Evaluation Through Phantom Studiesmentioning

confidence: 99%

“…Liquid compartments are made of varying concentrations of Intralipid (%10, F. K. Clayton, NC) and Indian ink (Winsor & Newton, England) in water. Details of the system calibration and image reconstruction have been thoroughly discussed in [4].In addition to regular phantom studies, due to significant improvement in data acquisition speed, for the first time, we were able to conduct a series of dynamic contrast enhanced DOT and MR-DOT phantom studies using indocyanine green (ICG) [5]. Our analysis shows that ICG kinetics curves obtained by the frequency domain DOT system have the potential to characterize the tumor permeability.…”

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confidence: 99%

Combined MR and Optical Imaging System for Noninvasive Tumor Characterization and Quantification of Oxygenation Gain Factor in a Breast Cancer Animal Model

Shafiiha¹

2007

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)01/06/07 (From -To) REPORT TYPE Annual DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of California Irvine, CA 92697 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACT:This study proposes to modify and improve an existing MR-compatible optical tomography system that is used for non-invasive tumor characterization and provides higher sensitivity and specificity for cancer imaging. The proposed research will conduct animal studies to evaluate the system's performance in distinguishing malignant from benign tumors in vivo. Additional experiments will be designed to assess the method's sensitivity to quantifying oxygenation gain factor in breast tumors. This investigation will have important implications for studies identifying tumor's hypoxic regions. Tumor hypoxia is believed to be strongly associated with tumor progression, prognosis, and resistance to therapy. In the first year of this multidisciplinary postdoctoral training grant, the principal investigator acquires training in breast cancer and dynamic contrast enhanced MRI. The major focus is on optical imaging system development/improvement and performance evaluation through phantom studies. We managed to increase the data acquisition speed by a factor of 10, which enabled us to perform dynamic contrast enhanced diffuse optical tomography on phantoms for the first time. SUBJECT TERMS INTRODUCTIONIn the last decade a variety of multi-modality imaging techniques have been developed to obtain complementary information and cross-validate measurements to investigate the differences in the physiological properties of benign and malignant tumors, and hence make tumor assessment more reliable. Magnetic resonance imaging (MRI) and near-infrared diffuse optics are non-invasive techniques that provide compleme...

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“…In addition to these studies, Unlu et al (2008a) demonstrated simultaneous acquisition of enhancement kinetics of a MR and an optical contrast agent using a hybrid MR-DOT animal imaging system. Moreover, Cuccia et al (2003) used the six-parameter pharmokinetic model and presented a study of the dynamics of the ICG in an adenocarcinoma rat tumor model by the use of diffuse optical spectroscopy co-registered with MRI.…”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT): experimental validation with a dynamic phantom

Ünlü¹,

Lin²,

Gülşen³

2009

Phys. Med. Biol.

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Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT) can provide spatially resolved enhancement kinetics of an optical contrast agent. We undertook a systematic phantom study to evaluate the effects of the geometrical parameters such as the depth and size of the inclusion as well as the optical parameters of the background on the recovered enhancement kinetics of the most commonly used optical contrast agent, indocyanine green (ICG). For this purpose a computer-controlled dynamic phantom was constructed. An ICG–intralipid–water mixture was circulated through the inclusions while the DCE-DOT measurements were acquired with a temporal resolution of 16 s. The same dynamic study was repeated using inclusions of different sizes located at different depths. In addition to this, the effect of non-scattering regions was investigated by placing a second inclusion filled with water in the background. The phantom studies confirmed that although the peak enhancement varied substantially for each case, the recovered injection and dilution rates obtained from the percentage enhancement maps agreed within 15% independent of not only the depth and the size of the inclusion but also the presence of a non-scattering region in the background. Although no internal structural information was used in these phantom studies, it may be necessary to use it for small objects buried deep in tissue. However, the different contrast mechanisms of optical and other imaging modalities as well as imperfect co-registration between both modalities may lead to potential errors in the structural a priori. Therefore, the effect of erroneous selection of structural priors was investigated as the final step. Again, the injection and dilution rates obtained from the percentage enhancement maps were also immune to the systematic errors introduced by erroneous selection of the structural priors, e.g. choosing the diameter of the inclusion 20% smaller increased the peak enhancement 60% but changed the injection and dilution rates only less than 10%.

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A simulation study of the variability of indocyanine green kinetics and using structurala prioriinformation in dynamic contrast enhanced diffuse optical tomography (DCE-DOT)

Cited by 10 publications

References 41 publications

An extended analytical approach for diffuse optical imaging

An extended analytical approach for diffuse optical imaging

Combined MR and Optical Imaging System for Noninvasive Tumor Characterization and Quantification of Oxygenation Gain Factor in a Breast Cancer Animal Model

Dynamic contrast-enhanced diffuse optical tomography (DCE-DOT): experimental validation with a dynamic phantom

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