A simplified synthesis of 2,3,5,6‐tetrafluorophenyl 2‐(2‐nitroimidazol‐1‐yl) acetate

Abstract

Summary2,3,5,6-Tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate has been synthesized via an improved route which involves the direct coupling of 2-(2-nitroimidazol-1-yl) acetic acid with 2,3,5,6-tetrafluorophenol.

In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography

“…N-[2-(toluene-4-sulphonyloxy)-ethyl]-phthalimide (I in Figure 1) was prepared according to the literature method (Tewson, 1997). The precursor, 2,3,5,6-Tetrafluorophenyl 2-(2-nitroimidazol-1-yl) acetate, (II) was prepared by a novel method, published separately (Wilson, 2003 (Ruth and Wolf, 1979). A measure of 250 ml 0.1 M K 2 CO 3 and 3 mg [2,2,2]Kryptofix in 500 ml acetonitrile were added to the [ 18 F]fluoride.…”