A simplified method of estimating renal function with iodohippurate I131

Background: Endothelin-1 (ET-1) is potent vasoconstrictor peptide which is able to contribute to the functional and structural renal changes. The aim of this study was to investigate the relationship between plasma concentration of ET-1 and indices of renal function in patients with diabetic nephropathy. Methods: We measured plasma ET-1 levels in 99 patients with type 2 diabetes, divided into two groups according to the values of their glomerular filtration rate (GFR): group I (GFR ! 60 mL/min/1.73 m

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“…22 Normal ERPF values were calculated using regression equations by Schernthaner et al 21 as follows:…”

Section: Erpf Measurementmentioning

confidence: 99%

Plasma endothelin-1 level, measured glomerular filtration rate and effective renal plasma flow in diabetic nephropathy

et al. 2015

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“…ERPF was determined by the clearance of 131 I-hippuran in two blood samples, which were taken at 20 and 30 minutes according to Blaufox's method [6]. The normal ERPF values were calculated using regression equations by Schernthaner et al [7] as following: For women : ERPF= 673,3 -(2.92*years of age) For men: ERPF = 854,2-(5.4*years of age)…”

Section: Acementioning

confidence: 99%

The effect of angiotensin converting enzyme inhibition on effective renal plasma flow in patients with diffuse renal parenchymal diseases and hypertension

et al. 2014

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The application of angiotensin converting enzyme inhibitors in patients with diffuse renal parenchymal disease and in individuals with essential hypertension may result in significant hemodynamic changes in the kidney, accompanied by changes in effective renal plasma flow. The extent of the changes caused by angiotensin converting enzyme inhibitors depends on the preexisting functional status of the kidney.

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“…Approximately 83% of radiohippuran is removed from the plasma in a single passage through the kidney and its clearance value can thus be used as a measure of effective renal plasma flow (Lawrence, Doig, Knight, MacLaren, and Donald, 1964), and Gott, Pritchard, Young and Maclntyre (1961) and Blaufox, Frohmuller, Campbell, Utz, Orvis, and Owen (1963) have shown that the clearance value obtained following a single intravenous injection of radiohippuran correlates well with effective renal plasma flow measured by P.A.H. clearance.…”

mentioning

confidence: 99%

Measurement of the fall in the level of plasma radioactivity after intravenous administration of radiohippuran as a test of renal function

Briggs¹,

Boyle²

1965

Journal of Clinical Pathology

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SYNOPSISThe level of plasma radioactivity following a single intravenous injection of 131I-labelled sodium orthoiodohippurate (radiohuppuran) falls with time in a tri-exponential fashion. The rate of fall of plasma radioactivity after an intravenous injection of radiohippuran was measured over the period 25 to 40 minutes from the time of injection and was expressed as the half-life of radiohippuran. The results suggest that this procedure may provide a valid measure of renal function which is more sensitive than the blood urea estimation but less sensitive than the creatinine clearance.

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A simplified method of estimating renal function with iodohippurate I131

Cited by 28 publications

References 2 publications

Plasma endothelin-1 level, measured glomerular filtration rate and effective renal plasma flow in diabetic nephropathy

Plasma endothelin-1 level, measured glomerular filtration rate and effective renal plasma flow in diabetic nephropathy

The effect of angiotensin converting enzyme inhibition on effective renal plasma flow in patients with diffuse renal parenchymal diseases and hypertension

Measurement of the fall in the level of plasma radioactivity after intravenous administration of radiohippuran as a test of renal function

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