A simplified histoscore for the estrogen receptor assay in breast cancer

Benı́tez-Bribiesca, Luis; Guevara, Rosa América Meléndez; Ruíz, Mariano; Martı́nez, Gloria; Rodrı́guez-Cuevas, Sergio

doi:10.1016/s0344-0338(11)80038-5

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…The determination of estrogen receptor (ER) and progesterone receptor (PR) status has direct therapeutical relevance as receptor‐positive cases are subjects of adjuvant antihormonal treatment (10). Despite numerous attempts for quantitative evaluation (11–14), steroid receptor status is assessed most frequently by microscopy following immunohistochemical staining. In addition, evaluation is complicated by the presence of a nontumorous component in the sample and by the heterogenous level of the expression in individual tumor cells.…”

mentioning

confidence: 99%

Determination of ploidy and steroid receptor status in breast cancer by laser scanning cytometry

Bollmann¹,

Torka²,

Schmitz³

et al. 2002

Cytometry

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mentioning

confidence: 99%

Determination of ploidy and steroid receptor status in breast cancer by laser scanning cytometry

Bollmann¹,

Torka²,

Schmitz³

et al. 2002

Cytometry

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“…4 b (ERI) and c (PTX) . The intensity of the staining was evaluated by Histoscore (H-score) at hot spot 26 . cGAS (H-score: 0–175) was localized mainly in the cytoplasm, but partially in the nucleus; STING (H-score: 0–220) and IFNβ were stained in the cytoplasm and RAD51 (H-score: 0–270) was stained in the nucleus.…”

Section: Resultsmentioning

confidence: 99%

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Yamada,

Takada,

Ghone

et al. 2024

Sci Rep

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Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore ERI's effects on the cGAS-STING pathway. Additionally, the nuclear presence of cGAS remains poorly understood. This study uniquely delves into ERI’s impact on both the cytosolic cGAS-STING pathway and nuclear cGAS. ERI enhances nuclear localization of cGAS, resulting in hyper-activation of the cGAS-STING pathway in triple-negative breast cancer cells. Reduction of cGAS heightened both cell proliferation and ERI sensitivity. In clinical data using ERI in a neo-adjuvant setting, patients with low cGAS cases exhibited reduced likelihood of achieving pathological complete response after ERI treatment. These findings illuminate the potential of cGAS and IFNβ as predictive biomarkers for ERI sensitivity, providing valuable insights for personalized breast cancer treatment strategies.

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“…The intensity of the staining was evaluated by Histoscore (H-score) at hot spot. 27 cGAS (H-score: 0-175) and IFNβ (H-score: 0-274) were predominantly localized in both the cytoplasm and nucleus; STING (H-score: 0-220) was stained in the cytoplasm and RAD51 (H-score: 0-270) was stained in the nucleus.…”

Section: Patients With Low Cgas and High Rad51 Associated With Non Pc...mentioning

confidence: 99%

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Yamada,

Takada,

Ghone

et al. 2023

Preprint

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Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore ERI's effects on the cGAS-STING pathway. Additionally, the nuclear presence of cGAS remains poorly understood. This study uniquely delves into ERI's impact on both the cytosolic cGAS-STING pathway and nuclear cGAS. ERI enhances nuclear localization of cGAS, resulting in hyper-activation of the cGAS-STING pathway in triple-negative breast cancer cells. Reduction of cGAS heightened both cell proliferation and ERI sensitivity. In clinical data using ERI in a neo-adjuvant setting, patients with low cGAS cases exhibited reduced likelihood of achieving pathological complete response after ERI treatment. These findings illuminate the potential of cGAS and IFNβ as predictive biomarkers for ERI sensitivity, providing valuable insights for personalized breast cancer treatment strategies.

show abstract

A simplified histoscore for the estrogen receptor assay in breast cancer

Cited by 6 publications

References 12 publications

Determination of ploidy and steroid receptor status in breast cancer by laser scanning cytometry

Determination of ploidy and steroid receptor status in breast cancer by laser scanning cytometry

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

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